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thetranscendedman Profile picture
@atranscendedman
Jul 22 • 2 tweets • 1 min read • Read on X
Paris researchers studied golden hamsters and found that SARS-CoV-2 can persist in the brainstem for 80 days, triggering gene changes linked to neurodegeneration and causing depression-like behavior, memory loss, and anxiety-like symptoms.

nature.com/articles/s4146…
btw this is low level replicating virus they isolated AND viral proteins.

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More from @atranscendedman

thetranscendedman Profile picture
Dec 22, 2024
What if the NIH focused on basic science and testing existing COVID treatments instead of studies on melatonin and light therapy?

Articles like this are frustrating because they highlight the waste in treating symptoms without addressing the root cause.

kevinmd.com/2024/12/long-c…
It’s astonishing that massive trials can continue despite patient protests and clear evidence showing resources should be redirected.

It seems no one wants to confront the hard truth, even when we could reinvest in more worthwhile projects.
Imagine spending millions to prove that melatonin or light therapy helps with sleep, or that exercising with pacing and PEM awareness is beneficial.

It’s an absurd waste of time and money. I’ve yet to see a convincing argument to justify it.
Read 17 tweets
thetranscendedman Profile picture
Nov 22, 2024
Michael Peluso on viral persistence at Demystifying Long COVID International 2024

Small thread 🧵
1/ "At the beginning of the pandemic I was not a believer in SARS-CoV-2 persistence, but have now become more convinced with data emerging" Image
2/ Cats can get a chronic illness called FIP in GI tract and is treated with coronavirus therapeutics.

Should work more closely with veterinary sciences. Image
Read 20 tweets
thetranscendedman Profile picture
Nov 21, 2024
Demystifying Long COVID International Conference 2024.

Mini-thread as most content is repeated from earlier this year. 🧵
1/ Introduction covered the importance of Long COVID. Mostly building on-top of Peluso/Deeks recent mechanisms paper.

Various sessions on how Long COVID impacts various cohorts and systems.

Will post interesting posters real quick:
2/

A study from Shamir Medical Center and Tel Aviv University followed 31 long COVID patients after hyperbaric oxygen therapy (HBOT).

Improvements in cognitive, sleep, and pain symptoms seen post-HBOT lasted over a year.
Read 21 tweets
thetranscendedman Profile picture
Nov 13, 2024
I’m open-sourcing a multi-agent Long COVID project from my Master’s Program at UT Austin to explore the disease’s mechanisms, suggest interventions, and test combination treatments.

github.com/JonDouglas/lon…
You can view the output of previous runs in these two folders.

gpt-4o-mini - github.com/JonDouglas/lon…

gpt-4o - github.com/JonDouglas/lon…

Example of interventions identified for each model: Image
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I was curious to see if I could replicate the results I’ve been noticing in these small research circles, wondering if I’d get similar outcomes.

What I found was…yes, though it’s not flawless.

But honestly, this is impressive for something that costs less than $1 USD to run. Image
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Read 5 tweets
thetranscendedman Profile picture
Nov 8, 2024
PolyBio Fall Symposium 2024 thread 🧵

1/
Amy Proal introduces the Fall Symposium. PolyBio is a non-profit org building a collective to solve diseases like Long COVID, ME/CFS, and more

They recently published a new project page to see how these projects map to the human body



2/polybio.org/consortium-pro…
She mentions a new grant about being able to ship samples from severe patients and how they were successful doing home visits in projects.

Goes over how each group is working on what with beautiful visualizations.

3/ Image
Read 58 tweets
thetranscendedman Profile picture
Jul 7, 2024
🧬 MENSA tech uses new antibodies to detect ongoing COVID-19 & viral reactivations in #LongCOVID. With 60% accuracy for SCV2, EBV, CMV, HSV2, it offers diagnostics from a single blood sample.

Differentiates between infection and vaccination responses.

medrxiv.org/content/10.110…
This is important. Here's why:

- Accurate detection of viral persistence
- Identification of latent reactivation
- Single blood sample
- High sensitivity & specificity
- Distinguishes infection & vaccination
- Extend to other chronic illnesses
- Non-invasive
- Clinical biomarker


Image
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Imagine this flow:

Your doctor takes a blood sample

The lab isolates your immune cells

They grow in a dish to produce fresh antibodies (MENSA)

MENSA is tested for various viruses

If MENSA has antibodies, it means persistence/reactivation of those viruses
Read 7 tweets

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