A new study has shown that a simple, cheap over the counter supplement can have regenerative & life saving benefits for the brain in one week.
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This study gave people with physical damage to the brain (traumatic brain injury or TBI):
ā A single dose of 4 g of N-acetylcysteine (NAC)
ā Then 2 g every 12 hours for 4 days
ā Then 1.5 g every 12 h for 3 days
on top of standard TBI treatment.
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Though the NAC group was similar overall to the placebo group (who only received standard TBI treatment),
more people in the NAC group (75%) had severe brain injury in comparison to the control (55%) at the beginning of the study.
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NAC improved metrics of inflammation and damage across the board:
ā Reduced IL-6 (inflammatory cytokine)
ā Improved MDA (marker of oxidative damage)
ā Lower NSE + S100B (intracellular proteins that get released when brain cells die)
again, all within one week. (4/8)
NAC didn't just improve blood markers - it improved real outcomes too.
People on NAC improved by over 53% on the GCS - a measure of cognitive function following brain injury.
Those on standard therapy alone? Just under 13%.
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People taking NAC also spent significantly less time in the hospital,
on average getting out of the ICU about a week in advance.
Another sign that the NAC is working quickly to help repair the brain.
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NAC improved survival from brain injury.
10% of people died after 28 days who used just one week of NAC.
30% of people without NAC died over that same time period.
Remember, more people had severe TBI in the NAC group as well - making these results even more impressive.
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Traumatic brain injury causes the release of damaged cell parts, which triggers inflammation, which then increases oxidative stress.
These processes further worsen brain damage, mitochondrial function and cognition.
NAC works in multiple different ways to protect the brain from this type of injury.
1. Prevents excessive oxidative stress from damaging cell components (by being a glutathione precursor) 2. Prevents oxidative stress from disrupting mitochondrial function - which supplies neurons with necessary energy to survive and thrive 3. Inhibits the activation of microglia - inflammatory cells of the brain 4. Prevents excessive glutamate release - which can trigger excitotoxicity in neurons
All of this prevents cell damage, death and energetic deficiency, which allows cells to stay alive and continue the healing process.
If you're interested in getting personalized help on targeted supplementation, nutrition and lifestyle to suit your health goals, schedule a free call with us here: go.prism.miami/consultation
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Iron can actually SHORTEN your lifespan and age you on a cellular level.
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This study was published in 2024, investigating the effects of iron chelation on age related parameters.
They used a common aging animal model - a Klotho knockout animal.
Animals are known to have shorter lifespans without this gene, and longer lifespans with more of it.
They gave them a drug called deferiprone, which binds up free iron and gets rid of it.
What exactly does klotho do?
Well it's main function is a co-receptor for FGF proteins, which govern various metabolic functions (fat burning, glucose uptake, etc.) as well as vitamin D synthesis.
But it also shows a number of other anti-aging effects:
N-acetylcysteine (NAC) was shown to reverse brain damage from aluminum in a critical study.
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Animals were put into 6 groups - either getting aluminum or NAC or both.
The aluminum was administered as aluminum chloride, and it was done so orally.
This is important because roughly only 0.5% of oral aluminum chloride is absorbed, so the real effective doses the animals received were far less than than the 100 mg / kg.
This is still a high dose, but aluminum is known to accumulate in tissues.
Animals had severely impaired memory performance with the aluminum, but this was improved with NAC.
The morris water test trains rats to find a hidden platform in pool.
The latencies (times) is how long it takes to find it on a given day.
Less time = better memory.
As you can see, the high dose NAC almost completely reversed the memory impairment from aluminum.