Pseudonyms afforded the protection needed to write things that were controversial, to engender debate over things they didn't themselves believe in, and to encourage focus on ideas over reputations
Thread of their known pseudonyms🧵
Alexander Hamilton, James Madison, and John Jay all wrote under the name Publius, after the Roman consul Publius Valerius Poplicola.
This shared authorship became known after Hamilton died, but the individual authors of the Federalist Papers Publius entries remain debated.
John Jay and John Stevens, Jr. shared the Americanus pseudonym when writing various Federalist essays.
Robert Yates and Melancton Smith co-wrote under the name Brutus, the Roman Republican better known his role in the assassination of Caesar.
Samuel Bryan wrote the majority of the letters published by the pseudonym "Centinel", but he co-wrote some entries under the name with George Bryan and—perhaps—Eleazer Oswald, too.
We actually don't know all of the pseudonyms used by some of the Founding Fathers.
For example, Alexander Hamilton wrote as...
Phocion, the Athenian statesman, when defending the Jay Treaty.
Hamilton wrote as Columbus—in defense of the Continental Congress—and as Pacificus—against war.
Curiously, both Hamilton and Franklin wrote separate pieces under the name Historicus.
They had no apparent connection.
The same thing happened with John Adams using the name Poplicola, one and the same as Publius Valerius Poplicola from Hamilton, Madison, and Jay's writings.
Benjamin Franklin wrote under many pseudonyms, and it's clear no one knows them all.
His pseudonyms like Richard Saunders (i.e., "Poor Richard") were sometimes known to be him, and the pseudonyms would sometimes write that they were not—sometimes seriously, sometimes jokingly.
Benjamin Franklin often wrote as a woman.
For example, he wrote as Silence Dogood, to provide social commentary. Sometimes the names were a little sillier, like Martha Careful, or Caelia Shortface.
Under the Shortface name, Franklin even wrote physical threats to himself.
Another humorous instance of name collision came from when two Founding Fathers wrote as an individual with the surname "M'Sarcasm".
Presumably this was named for the character in Love À-la-Mode.
They hyperbolically agreed with positions their real authors disagreed with.
Some names were just absurd:
Croaker, Roderick Razor, Peep Junior, Skyaugusta, Tom Tell-Truth, Federalissimo, Betsey Cornstalk, Patience, Busy Body, and more.
Perhaps the most absurd pseudonym user was none other than Samuel Adams.
Why? Well...
Samuel Adams wrote under no fewer than twenty different pseudonyms, oftentimes to provide the appearance that many people supported his views.
He also wrote under pseudonyms in order to slander people and to write absurd things to drum up readership.
All in good fun!
Do you know how the New York Post was founded?
Hamilton. Again.
And to kick it off his new publication in 1801, he wrote eighteen articles under the pseudonym "Lucius Crassus", violently criticizing Jefferson's presidency.
The list goes on.
Many Founding Fathers wrote under pseudonyms, before and after the Revolutionary War, for work and for pleasure, and sometimes simply for jokes.
Some even wanted to have a sparring partner when no one else would debate them, so they had to debate themselves.
In some cases, people sought to limit the 'pseudonym problem'.
For example, Benjamin Russell, printer of the Massachusetts Centinel, announced that he wouldn't print antifederalist essays unless the authors would reveal their names upon request.
None agreed to his terms.
In another case, a man going by "A Farmer" (a pseudonym!) proposed that the printer of the Gazette of the State of Georgia keep a roster of all of the names of anonymous essay writers.
His goal? To stifle discourse.
Ironically, he wouldn't dare do this under his own name!
The Founding Fathers were not alone in doing all of this, either.
Literary and scientific greats have written under pseudonyms since time immemorial (and beyond).
From Isaac Newton to Søren Kierkegaard to Mary Ann Evans—this tradition has been commonplace in Europe for ages.
What I want to convey is that there is an American tradition harkening to before the Founding and extending far beyond it.
That tradition is pseudonymous writing, and it's as American as apple pie.
Always has been, and for goodness' sake, let's hope it always will be.
The White House just released a really good executive order on cleaning up America's streets, re-institutionalizing insane people, and ending open air drug abuse and the problems it creates.
Here's a quick overview🧵
The first section is the one I'm most excited for. An alternative name for it could be "Bring Back The Asylums"
It instructs the administration to make it possible to involuntarily commit crazy people again
That crazy hobo pushing a cart full of urine bottles? He's going away!
The next section is one that you'll need to familiarize yourself with if you're interested in 'what happens next'.
This was a never achieved goal in Trump-I.
The idea is to compel cities to do what you want by withholding, barring, and giving discretionary funds for compliance.
What comes after myostatin inhibitors make everyone buff?
One new candidate is:
Safe, cheap, and easily-administered injections that locally remove fat. A new drug that just passed through phase 2 seems to do just that🧵
The new drug is called CBL-514.
It has a counterpart on the market in the form of deoxycholic acid injections—brand name Kybella.
Kybella is FDA-approved, and it works: it helps people to get rid of their double chins. But there's a catch.
Kybella, unfortunately, is not all that safe, and though many patients swear by it, there are notable side effects.
This is predictable, since the way Kybella works is through cytolysis: causing cells to die by rupturing them, releasing their contents, causing inflammation.
One of my favorite papers in recent years included this diagram.
It shows the impact of controlling for three different types of variables: confounders, colliders, and mediators.
With confounders, control is good. With the others, you ruin your result by controlling.
If you have variables with measurement error, you can run into another problematic variable: the proxy.
Proxy variables can make all of these distortions much worse and much more difficult to deal with.
The paper makes this simple observation: statistical control requires causal justification. That's actually the title.
They gave several DAG-based examples. Consider this one: is edutainment a confounder or a mediator? Should you control for it, or would that bias your estimate?
It's so good to see more gene therapies getting worked on.
This one is particularly amazing because it's effectively a one-shot, permanent Exenatide—making humans produce a version of the compound in Gila monster venom like lifelong Ozempic!
In the picture I posted above, you can see the effects of having variants that increase the effect of the gene GLP1R.
This was relevant when I was discussing compositional effects of GLP-1RAs. As you can see, bodyfat *percentage* declines with higher natural GLP-1R agonism.
I went ahead and checked the effects of the same SNPs and an extended set of SNPs on the effects of GLP1R on colorectal cancer risk.
It seemed to reduce it (pic is an excerpt from one of my subscriber-only posts).