Jake Scott, MD Profile picture
Aug 8 14 tweets 6 min read Read on X
@SecKennedy says he "reviewed the science" before terminating 22 mRNA vaccine projects worth $500M.

The "data" cited? 181 pages of cherry-picked lab studies ignoring all the high-quality evidence.

The US government is citing this as its scientific basis, which is outrageous:🧵
2/ This compilation is now the official basis for ending federal funding for Nobel Prize-winning technology that has averted millions of deaths.

I've been analyzing COVID vaccine safety data since the beginning. I reviewed what @HHSGov refers to has the "science."

Here's what's actually in it - and what's missing. jamanetwork.com/journals/jama-…
3/ What's missing

Just this week: Danish nationwide study of 1 million adults who got JN.1 boosters. Tracked 29 serious conditions for 28 days post-vaccination.

Result: No statistically significant association with any of the adverse events studied. For myocarditis specifically, the incidence rate ratio was 1.12 (95% CI: 0.41-3.10).

This is gold-standard safety monitoring. Kennedy's compilation doesn't mention it.
jamanetwork.com/journals/jaman…Image
4/ The packet claims "375 studies prove spike protein is toxic."

Look closer: Most are in vitro studies using recombinant spike proteins or pseudoviral vectors.

They inject spike directly into mouse brains. They use IV injection when vaccines are intramuscular. They use doses hundreds to thousands of times higher than any vaccine produces.

This is basic toxicology: the dose makes the poison. Water is lethal at high enough doses. These studies show hazard, not real-world risk. The packet's own papers say "we cannot infer any causality."
5/ Yes, myocarditis occurs after mRNA vaccination and must be taken seriously. We've tracked every case since 2021.

Highest risk: young males after dose 2. Peak rates in 2021: ~106 per million (16-17 year olds), ~52-56 per million (18-24 year olds). Most cases mild and self-limited: median 2-day hospitalization, full recovery typical.

Critical context: By 2024-2025, rates dropped to background levels. COVID infection causes more frequent and severe myocarditis. The Danish study of 1 million JN.1 recipients found no statistically significant cardiac risk.

Kennedy's packet ignores both the improving safety profile and the comparison to infection risk.
cdc.gov/vaccines/covid…
6/ The packet claims mRNA and spike protein spread everywhere: "heart, liver, brain, ovaries."

Their evidence? Studies where scientists inject mRNA intravenously in mice. Of course IV injection distributes everywhere. That's why we don't give vaccines IV. We inject into shoulder muscle, which creates completely different pharmacokinetics.

They also cite detection of trace amounts as if it means damage. Finding molecules somewhere doesn't equal harm. We can detect single molecules with modern techniques. The question is: at what concentration and for how long?
7/ "Spike protein persists for months!"

Read their own citations carefully. Vaccine spike is typically gone within two weeks. The studies showing months of persistence? Those measured spike from Sars-CoV-2 INFECTION, not vaccination.

They're deliberately mixing infection data with vaccine data. In the packet's own studies, vaccine mRNA degrades within days to weeks, and spike protein follows shortly after. The prolonged detection they cite comes from viral replication during infection, which vaccines don't cause.
8/ The packet claims anaphylaxis occurs in 1 in 2,280 doses.

CDC data from billions of real-world doses: about 5 per million (0.0005%). That's 400 times lower than the packet suggests.

For comparison: Penicillin causes anaphylaxis in 1 in 5,000. Peanuts in 1 in 50 for allergic individuals. The packet presents PEG reactions as unique to mRNA vaccines, but PEG is in toothpaste, cosmetics, and many medications. We don't ban those either.
cdc.gov/coronavirus/20…
9/ The packet's section on "immune imprinting" misrepresents basic immunology.

Yes, first exposures shape later responses. That's how all vaccines work. It's why we update flu shots yearly. The packet frames this as a fatal flaw, but their own sources call it a "design challenge" that can be addressed through updated formulations.

They claim vaccines "prevented antibody formation to other viral parts." But that's exactly what variant-updated boosters address. The same flexibility they're criticizing is what makes mRNA valuable.
10/ What's completely missing from Kennedy's 181 pages:

Global Vaccine Data Network: 99 million people, confirmed known rare risks, found no hidden dangers

CDC: Unvaccinated had 53x higher death risk during

Delta Commonwealth Fund: 3.2 million US lives saved through 2022 Cost-benefit: COVID cost $16 trillion. Vaccine investment: $18 billion. Return: hundreds to one.
cdc.gov/mmwr/volumes/7… commonwealthfund.org/blog/2022/two-…
11/ Here's what Kennedy just terminated based on this packet:

mRNA technology isn't just for COVID. We're killing vaccines for diseases that have plagued humanity for decades:

Norovirus (Phase 3): Would prevent 200,000+ hospitalizations yearly from the virus that shuts down schools and cruise ships. Any parents out there deal with norovirus like I have?! It's no picnic!

CMV (Phase 3): Would prevent the leading cause of non-genetic deafness in newborns

Lyme disease: Two vaccines in human trials offering seasonal protection

EBV: One for mono, another being tested to prevent
MS relapses

HIV: Early trials using germline-targeting approaches

All dead because of cherry-picked mouse studies.
modernatx.com/research-devel…
12/ Kennedy says he'll pivot to "safer, broader, whole-virus vaccines."

Those take 6+ months to update for variants. mRNA takes weeks. In the 2009 H1N1 pandemic, it took 6 months to retool egg-based production.

With mRNA, we went from sequence to trials in under 60 days.
H5N1 is currently spreading in dairy cattle. If it adapts to humans, that time difference between platforms won't be academic. It will be measured in lives.

And why take us backwards? Don't we want to make progress?
cdc.gov/bird-flu/situa…
13/ No respiratory virus vaccine has ever guaranteed sterilizing immunity. Not flu. Not RSV. The goal has always been preventing severe disease and death.
By that metric, mRNA vaccines succeeded spectacularly. Setting impossible standards and then declaring failure when they're not met isn't science. It's sabotage.
14/ This decision affects everyone.

As I told @JuliaElenaMusto @Independent

“Vaccines aren’t some niche drug. We’re talking about medicines that apply to literally every human being on the planet. We should have learned from the SARS-CoV-2 pandemic that everyone is potentially susceptible to pandemic threats.”

@HHSGov is citing mouse studies over billions of real doses. Setting impossible standards, then declaring failure. Terminating programs that could prevent the next pandemic.

This goes beyond bad policy. It actively undermines confidence in vaccines that work. When the next pandemic comes, we will need the very tools being dismantled.

Silence now will have a cost. And it will be measured in lives.
the-independent.com/news/health/rf…

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More from @jakescottMD

Aug 2
RFK Jr. is misrepresenting a landmark Danish study that followed 1.2 million children over 24 years. The study found no link between aluminum in vaccines and autism or neurodevelopmental harm. Let’s fact-check his claims - using actual data. 🧵
2/ This study represents gold-standard epidemiological research. Over 24 years, researchers tracked 1.2 million children across 50 health outcomes. Edward Belongia, leading vaccine safety expert: "the largest and most definitive observational study on the safety of vaccine-related aluminum exposure in children" ever conducted. pubmed.ncbi.nlm.nih.gov/40658954/Image
3/ RFK Jr. claims the study was "designed not to find harm." That’s wrong. Different birth cohorts received different aluminum doses due to national policy changes - not parental choice. This “natural experiment” minimizes confounding and bias. It’s a strength, not a flaw.
Read 12 tweets
Jul 17
As an infectious diseases physician and vaccine specialist, I need to address several serious misrepresentations, baseless assertions, and factual errors in this post. 🧵
1/ Calling mRNA vaccines “genetic ‘vaccine’ products,” with “vaccine” in quotes, is a deliberate rhetorical move that undermines their legitimacy.

These are real vaccines by every scientific and regulatory standard. They generate protective immunity, prevent severe disease, and have saved millions of lives. The mRNA remains in the cytoplasm, never enters the nucleus, and is rapidly degraded within hours, providing temporary instructions for cells to make a harmless viral protein that stimulates protection. cdc.gov/covid/vaccines…
2/ The claim that “vaccines would never be the answer to an ongoing viral outbreak” ignores public health history. Vaccines were central to smallpox eradication, polio near-eradication, and the rVSV-ZEBOV (Ervebo) vaccine was instrumental in controlling later Ebola outbreaks in the DRC. cidrap.umn.edu/ebola/study-du…
Read 8 tweets
Jul 8
If anyone claims vaccines haven’t been properly studied, show them this:

We’ve now logged 500 randomized, controlled vaccine trials into our dataset with ~7.2M participants. The vast majority of trials reported safety outcomes. Many more trials to come.
bit.ly/4le8z7D
Huge thanks to the inspiration and co-leader of the project, @BradSpellberg, and to our amazing team of volunteers who have been putting many hours into this - @AliSMV7, @alejodiaz81, @DhandAbhay, @ThePharmFox, @zacroBID, @TravisBNielsen, Dr. Matthew Phillips, @SarahRawi1, @IDwithNWD, Dr. Kusha Davar, Dr. Devin Clark, and countless anonymous contributors.
And beyond those 500 trials with 7.2 million participants, vaccine safety doesn't stop at licensure.

Monitoring continues throughout each vaccine's lifecycle through a multi-layered surveillance system designed to detect rare or delayed reactions that even massive trials can miss.

In the U.S., this monitoring begins with VAERS, an early-warning system that allows anyone (patients, providers, or manufacturers) to report health events following vaccination. But while VAERS can highlight patterns, it doesn't establish causality.

That's where the Vaccine Safety Datalink (VSD) comes in. By linking electronic health records for millions of people across integrated health systems, the VSD allows researchers to compare outcomes in vaccinated and unvaccinated populations in near real time. When VAERS signals a concern, these databases help determine whether there's truly an increased risk.

COVID-19 vaccination put this infrastructure to the test. With hundreds of millions of doses administered, the system identified rare events like myocarditis and thrombosis with thrombocytopenia syndrome, sometimes affecting fewer than 10 people per million doses. The key was early detection and rapid investigation by the surveillance system.

This level of surveillance is unprecedented in medicine. Combined with rigorous pre-licensure trials, it forms one of the most robust safety monitoring systems in all of healthcare.
Read 4 tweets
Jul 2
1/ Tucker Carlson: “Do you think overall the COVID vaccine killed more people than it saved?”
RFK Jr: “The truth is, I don’t know.”

This is outrageous.
I do know.
The answer is: unequivocally no. 🧵
2/ RFK Jr then added:

“And the reason I don't know is because the studies that were done by my agency were sub-standard, and they were not designed to answer that question."

I cared for hundreds of COVID patients and watched far too many die - including young, relatively healthy adults who never had a chance to get vaccinated, or who declined it.

And I’ve reviewed the evidence. Many of the studies he’s dismissing are anything but “sub-standard.”

It’s not even close.
3/ Before vaccines, ICUs were overwhelmed. Hallways filled. Some hospitals had to triage patients - deciding who might receive care and who wouldn’t. The suffering was unlike anything any of us had seen in our careers.

Then vaccines arrived. Deaths plummeted. By mid-2021, nearly every fatal case was among the unvaccinated. That pattern held across hospitals and regions.
Read 9 tweets
Jun 30
This claim about the Amish deserves correction with actual data. 🧵
2/ Research shows that many Amish families do vaccinate their children. Studies find that anywhere from 41% to 85% of Amish parents have vaccinated at least some of their children, depending on the community and time period.
3/ The historical record also tells a very different story about health outcomes. The last U.S. polio outbreak, in 1979, occurred in unvaccinated Amish communities and resulted in 15 cases, including 10 with paralysis. A 1991 rubella outbreak among the Amish led to at least 10 babies born with congenital rubella syndrome, suffering heart defects, deafness, and blindness. And in 2014, the largest measles outbreak in the U.S. in over two decades infected 383 people, nearly all of them Amish, after unvaccinated missionaries returned from overseas.

These outbreaks didn’t resolve on their own. They were halted through large-scale emergency vaccination campaigns, often with active participation from Amish leaders and parents once the risks were clearly understood.
Read 6 tweets
Jun 25
RFK Jr's thimerosal thread is a masterclass in misinformation. Let's fact-check it line by line. 🧵
2/ CLAIM: “There are high bolus doses of mercury in flu shots.”

FACT: 96% of flu vaccines are thimerosal-free.
Multi-dose vials contain 25 mcg per dose. That’s not a “high bolus.”
fda.gov/vaccines-blood…
3/ CLAIM: "A compliant child could get 500 µg of ethylmercury."

FACT: This is mathematically impossible. Today’s formulations can’t reach that total. Multi‑dose flu vials hold 25 µg each. A child vaccinated every season from 6 months to 18 years (19 doses) would max out at 475 µg - and that assumes every dose came from a multi‑dose vial. But only about 4% of the U.S. flu‑shot supply for 2025‑26 is multi‑dose; single‑dose syringes are standard for kids. Realistic lifetime exposure is therefore a small fraction of 500 µg.
Read 14 tweets

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