James Throt MBBS, MD, PhD, FRCPath Profile picture
Aug 13 18 tweets 6 min read Read on X
Surging aggression. Language delays. Developmental issues. Teachers & parents report major changes in children

Lockdowns are often blamed. But many lockdowns were short (e.g. UK)

So what else changed in early childhood since 2020?

I’m a neurologist. Let's talk COVID & brains🧵
Let's be clear: lockdowns may have had an impact on some children, especially in unsafe homes or w/poor digital access. That shouldn't be denied.

But what we're seeing now goes far beyond what short-term isolation would explain, especially in children born after lockdowns ended.
Babies aren't socialised in their first 2-3 months to protect their fragile immune systems. Instead, they focus on bonding with caregivers.

So blaming lockdowns for behavioral issues in babies born during or after 2020 ignores the major factor: widespread infections in infancy. Image
Since 2020, UK children (incl infants) have been repeatedly infected with SARS-CoV-2:

- A virus that enters the brain
- Damages grey & white matter
- Shrinks the frontal cortex
- Alters neurological development

This is even after mild & asymptomatic infections.
The frontal lobe governs:

- Impulse control
- Language acquisition
- Emotional regulation
- Social behaviour
- Attention & learning
- Empathy

Subtle damage during development can profoundly affect behaviour and cognition.
Teachers are reporting:

- More violence, even in reception and Key Stage 1
- Children hitting staff & peers
- Difficulty with attention & following instructions
- Emotional volatility
- Delays in speech, literacy, writing, and social development

This is systemic. And new.
UK lockdowns were short-lived:

- Nurseries & early years reopened June 2020
- All year groups returned to school in September 2020
- Under-5s faced few social restrictions

Yet the youngest cohorts, many born after lockdowns, are showing the most concerning outcomes.

Why? Image
Here's what changed... mass infection became policy:

- No clean air in schools
- No real protections for staff or students
- No vaccines for under-5s
- Reinfections normalised, even encouraged to achieve "herd immunity"

COVID became routine for children.

That has consequences.
COVID is not just a respiratory virus.

It's neuroinvasive. It can:

- Cross the blood-brain barrier
- Persist in neural tissue
- Trigger brain inflammation
- Shrink the frontal cortex
- Affect white matter, connectivity, cognition

Even in mild /asymptomatic illness.
Even children born after lockdowns ended, who missed the brunt of restrictions, are showing worrying developmental trends:

- Delayed speech
- Poor attention span
- Trouble with emotional regulation
- Language & learning gaps

Kids will have had 3-6 covid infections before age 6.
Meanwhile, children who lived through the peak pandemic years are now in classrooms, and teachers are reporting:

- Violent outbursts
- Severe attention issues
- Struggles with empathy, self-control, and literacy

This points to something deeper than just lockdowns.
Multiple studies show COVID-19 affects developing brains:

🧠 Infants born to infected mothers show altered brain structure
🧠 Children post-covid show cognitive delays and inflammation
🧠 Even mild cases leave long-term neurological footprints
🧠 Risk grows with each reinfection Image
Image
In short:

UK children are being repeatedly infected, often within their most vulnerable developmental windows, by a virus that damages the brain.

We are normalising this. Ignoring it. Blaming everything but the virus itself.

That is a societal failure of staggering proportions
This thread isn't about fear, it's about recognition

Lockdowns had an impact, yes, but something else is driving this

We owe it to children to ask the hard questions

To protect them from repeat brain injury that may alter their development, and their futures, permanently

END Image
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It should come as no surprise that this situation ⬇️ is quickly deteriorating, having been reported on TODAY.

“Disturbing rise in domestic abuse among 16 to 25 year olds”

“Children as young as nine are asking about violent pornography and displaying misogynistic behaviour.”
I have no idea why Twitter/X decided to remove the images from the initial post in the thread, and instead write out a link for the tweet as a replacement.

But here is what was originally attached:
I would like to address today’s news that A-Level results have “risen again” and “top grades are up”, when this is in complete contradiction to the bulk of this thread.

My quoted thread below deals with this phenomenon and explains exactly what is going on here…
“Should be of concern to all of us”

Yet they turn a blind eye to the root cause of the problem.

These are our policymakers.

Frightening really.

(This is Canada, the problem is ubiquitous)

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More from @JamesThrot

Nov 10
Cognitive decline from repeated SARS-CoV-2 infections & the rise of AI tools like ChatGPT = a perfect storm.

Here’s why this could reshape society in ways most people aren’t ready for 🧵
Repeat infection = cumulative damage to the brain. Particularly the frontal lobe, which governs empathy, foresight, impulse control & reality testing.

That’s the part of the brain that lets you question, reflect & doubt. Without it, a person becomes gullible, rigid & manipulable
Now layer on the rise of AI chatbots

People increasingly use them to write, think, argue, even feel for them.
And these models are designed to appease, to mirror your biases, validate your delusions and give you the emotional texture of understanding without any of its substance
Read 9 tweets
Nov 7
We have not yet seen the worst of the neurological effects of Covid.

End.
What’s coming:

- Frontal lobe degeneration
- Personality & empathy decline
- Early-onset dementia
- Parkinson’s
- Alzheimer’s
- Motor neurone disease
- Chronic fatigue & dysautonomia

All accelerated by reinfection.

Reinfections that are happening 1-2x annually.
SARS-CoV-2 causes:

🧠 Neuroinflammation

🧬 Microglial activation

🩸 Microclots and vascular injury

⚡️ Disrupted dopamine and serotonin pathways

All of which are established pathways to Parkinson’s, Alzheimer’s and Frontotemporal Dementia.
Read 7 tweets
Oct 28
Why are Religion & Fascism rising? Two faces of the same psychological/neural process.

They’re far more intertwined, and dangerous, than you might have ever believed.

SARS-CoV-2-induced frontal lobe (brain) damage makes both more likely.

A neurologist’s explanation 🧵

1/17 Image
Image
Religion and authoritarianism share the same psychological architecture: submission to authority, suppression of doubt, and moral outsourcing.

Both dissolve individual responsibility and reward conformity over critical thought.

And both are on the rise, simultaneously.

2/
It’s no coincidence that the far right movement in the US is also deeply religious.

MAGA’s fusion of politics and evangelicalism isn’t accidental, it’s the merging of two cultic structures that thrive on fear, obedience and moral absolutism.

3/
Read 17 tweets
Oct 21
SARS-CoV-2 brain damage is real, happening with every infection.

Many of you are on infection number 6+, asymptomatic cases count.

It damages the region (frontal lobe) that governs empathy, compassion & the internal brake that stops us from saying or doing inappropriate things.
Which is why you now see it spilling into public life, a White House Press Secretary thinking “your mom” is an appropriate response to a journalist.

Leaders across the world saying things once unthinkable, blurting out cruelty, absurdity, and arrogance in equal measure.
You see the same behavioural decay across governments. Leaders snapping at reporters, trivialising mass death, ignoring public health.

This isn’t just moral rot. It’s neurological. A species repeatedly damaging its own frontal lobes will lose empathy long before it loses power.
Read 8 tweets
Oct 8
Since I’m a neuropathologist, I’ll put my two cents into this MND discussion.

SARS-CoV-2 isn’t just a respiratory virus. Emerging evidence shows it can infect human motor neurons. Could this link to motor neuron disease (MND)?

Let’s break down the neuropathology. 🧵
Direct infection of motor neurons:

SARS-CoV-2 enters via ACE2, NRP1, CD147 receptors and can replicate inside neurons.

These long, metabolically demanding cells are highly vulnerable to injury.
Neuroinflammation:

Infected neurons trigger microglial activation & astrocyte dysfunction, creating chronic inflammation.

Neuroinflammation is a known driver of MND, especially ALS.
Read 11 tweets
Oct 7
All the “there’s no evidence SARS-CoV-2 causes brain damage” takes I’ve seen are weak, unscientific, and often just opinion masquerading as fact.

Let’s break this down with actual facts, rather than mere conjecture. 🧵 Marc Veldhoen states: There was no lymphopenia, no superantigen, no immune damage/dysfunction/exhaustion. There are no large outbreaks of infections. Furthermore, there are no increases in cancers due to SARS-CoV-2 infection, no compounded risk of longCovid, etc. Now it is brain damage.
Marc Veldhoen states: Sneaky, nobody can see it, and nobody can be aware..... so they will always be right. They will blame everything and anything on SARS-CoV-2, regardless of its lack of plausibility or the absence of actual evidence. And all the ZeroCovid accounts are at it!
Claim: “No lymphopenia, no immune dysfunction, no long COVID.”

Fact: Multiple peer-reviewed studies show SARS-CoV-2 does cause lymphocyte depletion, immune exhaustion, and long-term neurological effects.

Denial ≠ evidence.
Claim: “No compounded risk of infections/cancers”

Fact: SARS-CoV-2 impairs immune memory in some patients & is linked to increased risk of complications

Chronic inflammation & immune disruption are known risk factors for cancer, it’s scientifically reckless to say “zero risk”
Read 10 tweets

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