Bryan Johnson Profile picture
Aug 20 4 tweets 2 min read Read on X
Genetically, I should be bald.

But I’m not.

I've worked very hard to maintain my hair....I've tried a lot of things over the years to stop hair loss and grow strong healthy hair. I’ve injected PRP and dutasteride into my scalp way too many times. That hurts like hell and I don’t think the PRP helped at all.

I tried a lot of other things too and few if any actually work. So my team and I built our own solution.

It’s the most advanced formulation I’ve seen.

It’s now available if you want to give it a try. Like all things with hair, you need to be consistent for at least 4 months.

Here’s what’s in it and why I’m excited about it.Image
0/ What the product has:

+ 8 biomimetic peptides, more than any other product. And in the highest concentrations.

+  We put every peptide in its own patented delivery system so it reaches the exact receptor it’s designed to target for maximum impact.

+ We integrated patented nanofluorosome technology that is activated by the Blueprint Laser Cap (avail in Sept).

The serum is water-based, lightweight and dries completely residue free.

Layers of interventions and actives stacked upon each other.
1/ The ingredients

Blueprint Peptide Serum:
1. sh-oligpeptide-1 - EGF
2. sh-oligiopeptide- 4 - Thymosin-β4
3. sh-polypeptide-4 SCF
4. sh-polypeptide -7 hGH
5. sh-polypeptide -9 VEGF
6. sh-Polypeptide-59 PDGF
7. sh-Polypeptide-86 Follistatin
8. Copper Tripeptide-1 GHK Tripeptide-1

Blueprint Shampoo (scalp treatment)
sh-oligopeptide-1 - EGF
sh-oligopeptide- 4 Thymosin-β4
sh-polypeptide -1 bFGF
sh-polypeptide -7 hGH
sh-polypeptide -9 VEGF
sh-polypeptide -11 aFGF
sh-polypeptide -71 -VIP
Copper Tripeptide-1 GHK
2/ Instructions

Step 1: Blueprint Peptide Shampoo (scalp treatment)
+ Wash hair with your regular shampoo. Rinse thoroughly.
+ Apply 1-2 pumps of Blueprint Shampoo directly to the scalp
+ Massage and lather onto scalp. It foams nicely.
+ Leave for 2 minutes
+ Rinse out
+ Follow with your regular conditioner routine

Why do I need another shampoo?
Blueprint Peptide Shampoo is a scalp treatment.

Wash with your regular shampoo first to remove oil and buildup, so this formula can work on a clean scalp and deliver peptides where they’re needed.

Step 2: Blueprint Peptide Serum
+ Apply daily to dry scalp
+ Use a dropper to apply directly to the scalp and focus on areas of concern.
+ One full dropper covers the entire scalp, adjust as needed.
+ Massage in
+ Wear the Blueprint red light laser cap (out Sept 2025) for 6 min to amplify activation of the ingredients
+ Wait until serum is completely dry, before using other styling products.

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More from @bryan_johnson

Aug 13
My morning routine temporarily improves vascular function to elite teenage levels.

Augmentation index: AIx of -5%
AP pressure: of -1 mmHg
Systolic: 87 mmHg, Diastolic: 49 mmHg.

Better than >90% to healthy males in their teens.🧵 Image
0/ Sauna has significantly improved my vascular and endothelial function, blood flow, and circulation.

Tracking my blood pressure and central pulse variables indicates blood pressure reductions and improved blood flow. These were observed following a comprehensive morning routine that includes sauna, HBOT, exercise, red light therapy, and other modalities.

Interventions in my morning routine
+ Sauna: functional vascular improvements (central pulse pressure), and increased VEGF.
+ HBOT: increased VEGF and improved blood flow.
+ Exercise: improves vascular function blood flow
+ Breathing exercise: lowers stress and blood pressure, increases HRV
+ Red light therapy RLT: improves mitochondrial function, skin, and muscle blood flow.
+ Combined sauna and HBOT increased my serum VEGF over 500% (now in upper normal range)
1/ Combination of sauna and HBOT in my morning routine achieved the same improvement again.

Following 49 sauna sessions: central pulse pressure at the end of my morning routine, immediately after the sauna:

+ Augmentation index: AIx of -5%
+ AP pressure: of -1 mmHg.

These markers measure arterial stiffness as they reflect the fraction of pulse pressure generated by the vasculature resisting blood flow.

Lower AIx and AP mean:
+ Blood vessels showing maximum compliance (minimal stiffness)
+ Ideal elasticity allowing my blood to flow smoothly
+ Elite 18-year old levels <97% of healthy 18-year-old males.

Possible synergy between Sauna, HBOT and exercise in my morning routine.
Read 5 tweets
Aug 11
I’m experimenting with methylene blue.

Clinical trials in humans show promise for brain health.
Animal studies show minimal to no efficacy in lifespan extension.

The potential: mitochondrial function and energy. 🧵 Image
0/ Methylene blue health effects are not yet well-researched, especially as it relates to fitness, performance, and longevity potential.

But it’s intriguing for mitochondrial function and energy enhancement, particularly for brain health in the context of neurodegenerative diseases.

Research indicates these benefits are plausible
+ Mitochondrial improvement and more efficient energy production
+ Boosting cognitive and brain health
+ Enhancing physical performance and exercise capacity (animal experiments)
+ Cellular longevity and senescence prevention (early evidence)
1/ My methylene blue protocol

+ 25 mg/day of methylene blue orally
+ 5 days a week
+ Keeping a 2-day weekly clearance break to prevent accumulation, especially in the brain
Read 11 tweets
Aug 7
I paused Metformin.
A longevity staple in my protocol for 5+ years.
But its effects on my body were shocking.

It built up my energy capacity,
but limited my ability to use 90% of it.

Here’s what we found. 🧵
Our hypothesis:

+ Metformin pushes the cells to recycle, repair, and build new mitochondria (mitochondria are the power plants of the cells).

+ Long-term use kept my cells locked in mitochondria build up mode (I had 3x more mitochondria than normal) but Metformin blocked this optimized mitochondria from being used.

Pausing Metformin unleashed my mitochondria’s full energy potential (spike in power came with more oxidative stress though).

We’re now cycling Metformin, which should give me the best of both worlds, mitochondrial build-up and optimal use.
Results so far

7 weeks off Metformin: new peaks in energy output.
My avg cycling power improved 25.6% over my previous personal best.

Energy markers are up across the board:Image
Read 4 tweets
Aug 5
Starting a new protocol: IHHT

+ alternates low and high oxygen
+ igniting mitochondria and boosting cellular energy
+ raising red blood cells and repairing vessels
+ accelerating recovery and improving cognition
+ slowing speed of aging Image
1/ My protocol

I will be using MitoVit system.

MitoVit utilizes a biofeedback mechanism to adjust the oxygen percentage in the delivered air, targeting specific blood oxygen saturation (SpO2%) levels.

As the protocol progresses, lower SpO2% values are targeted for a gradual and safe advancement towards maximum efficacy.
2/ Here is my IHHT protocol:

+ 35 days total
+ 26 biofeedback training sessions
+ 3:1 rhythm: three training sessions,one recovery

Cycle per Session (Biofeedback Mode):
+ 5 minutes training (hypoxia: SpO2 85→77%)
+ 3 minutes recovery (adaptive hyperoxia, 99% SpO2)
+ 5 cycles per session (40 minutes total)
+ Target SpO2 Range: 85% - 77%
Read 8 tweets
Aug 4
I work hard on my RHR for sleep. It's also an important health marker.

Last night it was 39 bpm.
My 30 day ave is 44 bpm.

Here's data that puts RHR in context. 🧵 Image
1/ My 39 RHR is slower than 99.97% of the population based upon a study analyzing sleep RHR data over 35 weeks from 92,457 individuals (aged 18-89 across all 50 US states).

+ my RHR is 22 bpm lower than the average male in their 20s.
+ and 22 bpm lower than individuals with elite BMIs and elite sleep durations.
2/ My 30-day RHR average is 44 bpm, which is:

+ Lower than 99.7% of the male population, according to the same study.
+ Lower than the range for 20-39 male athletes, according to WHOOP user data.

This achievement aligns with recent personal bests in blood pressure, vascular function and elasticity, blood flow, and HRV.
Read 4 tweets
Jul 23
Icing your boys in the sauna is a good idea.

Experiment #1:
+ sauna icing the boys improved fertility markers

Experiment #2:
+ no ice devastated fertility markers

Experiment #3:
+ icing again is healing the harm

My results explained and what to do🧵 Image
0/ The testicles are located “outside” the body in the scrotum specifically to maintain a temperature 2-4 °C below core body temperature, essential for optimal sperm production and storage (in the epididymis) .

Heat is known to multiple steps of spermatogenesis by disrupting the development of germ cells  and triggering DNA damage, oxidative stress and cell death.

This applies to heat exposure in sauna as well.

A single sauna session (20 min at 85°C) reduced sperm counts, full recovery took up to 5 weeks.

Continuous sauna for 3 to 6 months reduced the sperms with epigenetic structure and DNA packaging, and mitochondrial function all essential for fertilization.
My results starkly confirm this

1/ Beyond protecting my sperm, icing with sauna boosted all my sperm markers.

27 daily sauna sessions with ice on balls
+ total motile count ↑ 57%
+ concentration ↑ 26%
+ motility ↑ 16%,
+ normal morphology ↑ 15%

This is likely due to systemic sauna benefits, including improved blood flow and unparalleled detox effects, and possibly due to the direct effect of the daily cooling itself.
Read 7 tweets

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