🚨 Real-World GLP-1 Data: Vanderbilt Obesity Clinic Study (n=2,306)
Clinical trials showed 15–21% weight loss with semaglutide & tirzepatide. But how do patients actually fare in practice?
- - -
Key Findings:
📊 Median treatment duration: 10.7 months (50% discontinued by 12 months)
💉 Only 23% reached semaglutide 2.4 mg, 28% reached tirzepatide 15 mg
⚖️ Weight loss for those who continued treatment:
• 6 months: –9.4%
• 12 months: –14.4%
🏥 13.6% had medication-related ER visits (mostly GI side effects)
Context:
This was not a typical setting—patients had multidisciplinary support and NO-COST medication access through employer insurance bundles.
Reality Check:
✅ With the right care model, real-world outcomes can approach RCTs
❌ Most patients never reach target doses
❌ Half stop treatment within a year
👉 The gap between “can work” and “does work” remains large. Sustained success appears tied to comprehensive care models that most patients can’t easily access.
🔗…ubs.pericles-prod.literatumonline.com/doi/10.1111/do…
Clinical trials showed 15–21% weight loss with semaglutide & tirzepatide. But how do patients actually fare in practice?
- - -
Key Findings:
📊 Median treatment duration: 10.7 months (50% discontinued by 12 months)
💉 Only 23% reached semaglutide 2.4 mg, 28% reached tirzepatide 15 mg
⚖️ Weight loss for those who continued treatment:
• 6 months: –9.4%
• 12 months: –14.4%
🏥 13.6% had medication-related ER visits (mostly GI side effects)
Context:
This was not a typical setting—patients had multidisciplinary support and NO-COST medication access through employer insurance bundles.
Reality Check:
✅ With the right care model, real-world outcomes can approach RCTs
❌ Most patients never reach target doses
❌ Half stop treatment within a year
👉 The gap between “can work” and “does work” remains large. Sustained success appears tied to comprehensive care models that most patients can’t easily access.
🔗…ubs.pericles-prod.literatumonline.com/doi/10.1111/do…
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