Aravind Palraj Profile picture
Aug 27 16 tweets 5 min read Read on X
Here’s a thread on 10 general medicine lessons reinforced in rheumatology 🧵
Tweet 1:
Rheumatology isn’t “super-specialised.”
It’s general medicine… but deeper.
Every principle we learnt in MBBS comes back in rheumatology.
#MedTwitter #Rheumatology @IhabFathiSulima @DrAkhilX @CelestinoGutirr @Janetbirdope @docchennaiImage
Tweet 2
🌡️ Fever of unknown origin
Clues to think beyond infection:
• Rash that comes & goes
• Cytopenias
• Very high ferritin
• Hepatosplenomegaly
• Serositis

Sometimes, fever is inflammation wearing a disguise. Image
Tweet 3
🫀 Severe hypertension in a 20-something?
Always feel the pulses.
Bruits, unequal BP in arms → large vessel vasculitis.
Sudden crisis in systemic sclerosis → renal emergency.

Not all BP rises are “essential.” Image
Tweet 4
🧠 Headache that’s new-onset, with jaw pain & raised ESR in >50 yrs = red flag.
Giant Cell Arteritis is a race against blindness.

Treatment should start before biopsy, not after. Image
Tweet 5
🫁 Chronic cough despite antibiotics & anti-TB?
Think interstitial lung disease, pulmonary hypertension, or alveolar hemorrhage.

TB is common—but overdiagnosis is even more common. Image
Tweet 6
🩸 Anemia = not just “low Hb.”
• Microcytic → celiac overlap?
• Normocytic → chronic inflammation?
• Hemolytic → autoimmune?

Every Hb drop is telling you a story. Image
Tweet 7
👁️ Painful, recurrent red eye?
Often mislabeled “allergic conjunctivitis.”

Could be uveitis, episcleritis, or scleritis.
The eye sometimes diagnoses the joint before the joint hurts. Image
Tweet 8
🦴 Back pain in the young:
• Insidious onset
• Morning stiffness >30 min
• Improves with activity

That’s inflammatory back pain.
Average delay in diagnosis = 7–10 years. Image
Tweet 9
🖐️ The skin is a map:
• Heliotrope rash → dermatomyositis
• Malar rash → lupus
• Digital ulcers → systemic sclerosis
• Vasculitic lesions → systemic vasculitis

Look at the skin. It whispers secrets. Image
Tweet 10
🧪 Positive ANA ≠ lupus.
ESR high ≠ infection.
Rheumatoid factor ≠ RA.

Tests don’t make diagnoses. Context does. Image
Tweet 11
🫁 Hemoptysis + drop in Hb + bilateral infiltrates = not pneumonia.
Think diffuse alveolar hemorrhage.

Needs immunosuppression, not antibiotics. Image
Tweet 12
🦵 Leg swelling in a young woman on OCPs? DVT.
But if she also has miscarriages → think antiphospholipid syndrome.

Every clot deserves a deeper look. Image
Tweet 13
🧴 Raynaud’s phenomenon
White → blue → red fingers on cold exposure.

In teenagers, often benign.
In adults, could be systemic sclerosis, MCTD, or lupus.

Don’t miss the systemic clue hiding in the fingertips. Image
Tweet 14
🧑‍🦽 Weakness isn’t always neuro.
If it’s proximal (difficulty combing hair, climbing stairs), check CK.

Could be myositis → treatable if caught early. Image
Tweet 15
💊 “Steroid responder” doesn’t mean asthma always.

If fever, rash, cytopenia melt away with steroids → think autoimmune flare or vasculitis.

Steroid response is a clue, not just a treatment. Image
Tweet 16 (Closer)
Everyday complaints can be routine.
Or they can be a zebra 🦓 hiding in plain sight.

The difference?
👉 Curiosity.
👉 Listening.
👉 Examining.

That’s how lives are saved.

#MedTwitter #FOAMed #ClinicalPearls

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More from @Rheumat_Aravind

Aug 23
🧵: The Eye & Rheum: A Clinician’s Guide to Ocular Manifestations
Tweet 1:
1/10 👁️ The eye isn’t just the window to the soul—in medicine, it’s a window to systemic disease. Many rheumatic conditions write their first, or most severe, chapters on the ocular surface. A thread for clinicians on the critical link between Rheumatology & Ophthalmology. #RheumTwitter #OphthoTwitter #MedEd @IhabFathiSulima @Janetbirdope @DrAkhilX @ACRheum @RheumNowImage
Tweet 2: Anatomy Primer
2/10 Before we dive in, let’s map the battlefield. Key structures where rheumatology makes its mark:
•Uvea: The pigmented middle layer (iris, ciliary body, choroid).
•Sclera: The tough, white outer layer.
•Cornea: The transparent front.
•Lacrimal Glands: The tear producers.Image
Tweet 3: Anterior Uveitis & Spondyloarthritis
3/10 The Classic Duo: Anterior Uveitis & Spondyloarthritis (SpA). A patient with acute, unilateral eye pain, redness, & photophobia? Think SpA, especially if they are HLA-B27+. This is often the first clue leading to an AxSpA diagnosis. #Uveitis #AnkylosingSpondylitisImage
Read 10 tweets
Aug 22
🧵 Drug vs Disease — When Side Effects Mimic the Diagnosis👇
Is it the disease—or the drug? Many “flares” are actually medication effects. Here’s a clinic-ready guide to the most common drug–disease confusions, what to check, and how to pivot fast. Save and share. #MedTwitter #RheumTwitter #FOAMed #IMTwitter #PrimaryCare #PatientSafety @IhabFathiSulima @DrAkhilX @JanetbirdopeImage
Post 1
Big idea
Before escalating therapy, ask: could the medication be causing or unmasking the symptom? Use this checklist: timing vs start/dose change, dose–response, dechallenge/rechallenge, and alternative explanations. Image
Post 2
NSAIDs vs kidney/pressure
•Looks like: edema, rising creatinine, “worsening gout/OA pain”
•Could be: NSAID nephrotoxicity or hypertension
•Check: creatinine/eGFR, BP, volume status; step down NSAID, switch to topical or COX-2 cautiously; renal-safe analgesia plan. Image
Read 16 tweets
Aug 20
🧵 Steroid Stewardship & Safe Tapering: A Practical Playbook👇
For clinicians across primary care, rheumatology, IM, EM, and dermatology
Steroids help fast—but harm fast without a plan. Here’s a concise, clinic-ready playbook: when to start, how to taper, who needs bone/GI/infection protection, and when to escalate. Save this thread, share with teams, and use it tomorrow. #RheumTwitter #MedTwitter #FOAMed #PatientSafety #PrimaryCare #IMTwitter
@IhabFathiSulima @DrAkhilX @ACRheum @IRAeNewsLetter @DurgaPrasannaM1 @CelestinoGutirr @NeuroSjogrens @nirmalregency @Janetbirdope @Lupusreference #MedTwitter #Rheumatology #RheumTwitter #PrimaryCare #GP #IMTwitterImage
Post 1
Steroids help fast—but harm fast if misused. Goals: shortest duration, lowest dose, clear taper, bone protection, and an exit plan. Save for clinic.
#MedTwitter #RheumTwitter #FOAMed #GP #PrimaryCare Image
Post 2
Before starting prednisone:
•Confirm inflammatory indication (not purely mechanical pain)
•Baseline: BP, weight, glucose, ±lipids; vaccine status
•Agree on dose, duration, taper, monitoring, rescue plan
#PatientSafety #ClinicalTips #IMTwitter Image
Read 15 tweets
Aug 20
Clinical Rheumatology Thread for Busy GPs:
Post 1
Early inflammatory arthritis(IA): the 3–3–3 rule
•Onset ≤3 months
•Morning stiffness ≥30–60 minutes
•≥3 swollen joints (MCP/MTP common)
If present, manage as IA: urgent rheum referral; NSAIDs if no contraindications.
@IhabFathiSulima @DrAkhilX @DurgaPrasannaM1 @Janetbirdope @ACRheum @RheumNow @Amansharmapgi @12VRavindran #MedTwitter #RheumatologyImage
Post 2
Red flags over patterns
Screen for: systemic (fever, weight loss, night sweats), vascular (new headache >50y, jaw/limb claudication), neuro/renal (hematuria, neuropathy).
Any present → same-week labs (CBC, ESR/CRP, creatinine, urinalysis) and escalate. Image
Post 3
Morning stiffness as a clue
60–90 min: inflammatory (RA, PMR, axial SpA)
•<30 min: mechanical (OA)
Pair with distribution: small joints=RA; spine/SI=axSpA; DIPs=PsA/OA. Image
Read 20 tweets
Aug 17
🧵 2025 AHA Hypertension Guidelines: Changes & New Updates
1/ The 2025 AHA/ACC hypertension guideline replaces the 2017 version with key, evidence-driven changes. Here are the must-know updates for your clinical practice.
@IhabFathiSulima @DrAkhilX @TrackYourHeart @sumersethi @Mahmoud33986639 @latchumanadhas #MedTwitterImage
2/ PREVENT Risk Equation Now Central
All therapy decisions now use the PREVENT risk score (not pooled cohort equations). The 10-year CVD risk threshold to start medication is now ≥7.5%—so more patients, especially with moderate risk, will get earlier treatment. Image
3/ Initiation of Therapy at Lower Thresholds
Stage 1 hypertension (130–139/80–89 mm Hg):
•If CVD, CKD, diabetes, or PREVENT risk ≥7.5%, start antihypertensive immediately.
•If PREVENT risk <7.5%: start with lifestyle changes for 3–6 months. If BP stays ≥130/80, add medication.
This expands eligibility —more aggressive than 2017.Image
Read 12 tweets
Aug 17
🧵 Hematological Manifestations in Autoimmune Diseases—2025 Clinical Update
1/ Blood disorders are common in autoimmune diseases and may be the first clue. Timely recognition can be lifesaving. Here’s a crisp clinical thread every practitioner should bookmark.
@IhabFathiSulima @DrAkhilX @CelestinoGutirr @HematologyAdv @EHA_Hematology #MedTwitter #RheumatologyImage
2/ 🦋 Lupus (SLE):
•Anemia (iron-deficiency, hemolytic, chronic disease, drug-induced)
•Lymphopenia
•Thrombocytopenia (may be severe)
All correlate with disease activity and need close monitoring. Image
3/ 🤲 Rheumatoid Arthritis (RA):
•Anemia of chronic disease
•Felty’s syndrome: RA + big spleen + neutropenia
•Drug-induced cytopenias (MTX, biologics)
•Blood markers (Hb, NLR) can predict flare/remission. Image
Read 12 tweets

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