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Dalton (Analyze & Optimize) Profile picture
@Outdoctrination
Aug 28, 2025 • 1 tweets • 1 min read • Read on X
Vitamin B1 (thiamine) megadosing can massively reduce fatigue, in many cases reversing it entirely.

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More from @Outdoctrination

Dalton (Analyze & Optimize) Profile picture
Feb 8
N-acetylcysteine (NAC) was shown to reverse brain damage from aluminum in a critical study.

(🧵1/8)Image
Animals were put into 6 groups - either getting aluminum or NAC or both.

The aluminum was administered as aluminum chloride, and it was done so orally.

This is important because roughly only 0.5% of oral aluminum chloride is absorbed, so the real effective doses the animals received were far less than than the 100 mg / kg.

This is still a high dose, but aluminum is known to accumulate in tissues.Image
Animals had severely impaired memory performance with the aluminum, but this was improved with NAC.

The morris water test trains rats to find a hidden platform in pool.

The latencies (times) is how long it takes to find it on a given day.

Less time = better memory.

As you can see, the high dose NAC almost completely reversed the memory impairment from aluminum.Image
Read 11 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 5
Vinegar drastically reduces blood sugar and insulin levels, according to multiple clinical trials.

(🧵1/7)Image
This first paper is a review article from 2017.

They looked at studies giving people vinegar alongside meals and monitored their blood sugar and insulin responses.

Having high levels of these post meal is highly indicative of insulin resistance and is a risk for heart disease.

Apologies, I do not have the official PDF so I'm working with the raw file here.Image
Here were the included studies.

Most are looking at roughly one tablespoon of vinegar alongside a meal with carbs. Image
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Read 10 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 5
Why you SHOULDN'T be hysterical about vitamin C causing kidney stones, and what to do to prevent them (🧵1/10):Image
The idea that vitamin C supplementation can cause kidney stones is not completely baseless, but it does lack context.

Ascorbic acid, or vitamin C, can get metabolized in our cells to create oxalate.

Oxalate is what binds to calcium to form kidney stones in most people.

Seems pretty straightforward, BUT...Image
Ascorbic acid mainly gets converted to oxalate under conditions of high oxidative stress.

That is when ascorbic acid (AA) turns into dehydroascorbate (DHA).

But we have glutathione to help regenerate ascorbic acid from dehydroascorbate.

This depends on your entire antioxidant network.Image
Read 12 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 4
FLUORIDE: The toxin in your water that destroys thyroid function.

Here's how, and what to do about it.

(🧵1/14)Image
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In 2024 a massive review of studies was done on the effects of fluoride exposure and markers of thyroid health.

The higher the fluoride concentration in:

◈ Drinking water
◈ Urine
◈ Serum

the higher the TSH level was - a marker of primary hypothyroidism.

TSH rises when the thyroid gland does not respond to stimulation.Image
More importantly, this study showed a marked decrease in thyroid hormones from higher water fluoride concentrations.

The active T3 thyroid hormone and the precursor thyroid hormone T4 both drop off with higher water fluoride concentrations. Image
Read 16 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 3
A recent study showed that vitamin K2 was protective against every single metric of dental health measured.

(🧵1/8)Image
This paper came out in 2023 in Healthcare.

They aim was simple - look at vitamin K2 levels in relation to dental health.

They did this by looking at carboxylated osteocalcin levels - which reflects whole body K2 status. Image
Specifically they were looking at a condition called periodontitis.

This is essentially dental inflammation, especially in the gums but also impacting the teeth themselves.

These are the stages, with gingivitis being early and stage 5 being very severe. Image
Read 11 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 1
An astounding study shows that 1/2 a teaspoon of baking soda lowered inflammation within hours.

(🧵1/9)Image
Study was published in 2018 in The Journal of Immunology.

Some experiment were done in rodents including baking soda in the water.

Some groups had their vagus nerves cut.

Other animals had a surgery to disturb the spleen.

Both surgeries were done to see if these tissues mediated the effect of baking soda.

Then, the human studies were done comparing drinking 2g of baking soda dissolved in water vs 2g of salt.

(2/9)Image
Animals consuming baking soda in the water showed decreased inflammation in several areas.

In both the kidneys and in the spleen, they had decreased inflammatory M1 macrophages, one of the primary immune cells.

Baking soda increased M2 macrophages, signifying that the macrophages turned into a more anti-inflammatory phenotype.

They also had:

↑IL-10 in the kidney (anti-inflammatory cytokine)
↑FOXP3 cells in blood + kidney (Treg cells, anti-inflammatory immune cells)
↓CD4 T Cells (inflammatory)
↓CD44 T cells (inflammatory)
↓TNFα macrophages (primary inflammatory mediator)

(3/9)Image
Read 10 tweets

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