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Sep 1 β€’ 9 tweets β€’ 3 min read β€’ Read on X
Creatine might raise IQ.

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The first study investigating this topic was in 2003.

They took vegetarians in their mid 20s and gave them 5g of (or placebo) for 6 weeks, then no creatine for 6 weeks, and then switched groups for another 6 weeks.

The break was done to see if any benefit went away without creatine.

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Subjects took two cognitive assessments.

Raven’s Advanced Progressive Matrices (RAPM) = nonverbal test of abstract reasoning & pattern spotting.

Wechsler Backward Digit Span (BDS) = working memory test (recall numbers in reverse).

Both tap core cognitive abilities that strongly predict IQ scores.

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During the creatine portions (weeks 0-6 & 12-18) - both intelligence metrics markedly improved.

Scores began to decline once creatine was stopped, but remained higher than starting levels for weeks after.

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A more recent study showed similar effects.

Creatine (or placebo) was taken at 5g a day for 6 weeks.

They did the same 2 cognitive tests.

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Once again, both intelligence metrics improved with creatine.

When trying to compare the results directly to IQ tests, the researchers stated:

"If these were IQ tests, the increase in raw scores would
mean 1 and 2.5 IQ points."

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Creatine is incredibly important for the brain.

Like the muscles, creatine is stored in large amounts in the brain, and supports energy metabolism by acting as a way to replenish ATP.

This is vital for all functions of the brain, but in particular is needed for maintaining the charge of the neurons.

Without constant maintenance of this gradient, neurotransmitter signals and brain activity is not possible.

The brain is electric in nature. Creatine supports this.

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I've written more about the importance of creatine to the brain here, along with additional context:
If you want to improve long term brain / cognitive and general health, we'd be happy to help.

Book a free call with us here, and we can get you on the right path: go.prism.miami/consultation

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More from @Outdoctrination

Aug 31
A new study has shown that grounding boosts metabolism & reduces free radical production in the mitochondria.

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This study was published in June.

Grounding has shown multiple benefits, including:

- Reduction of inflammation
- Normalization of cortisol
- Decreased fatigue
- Lower blood sugar

So the goal here was to get a deeper understanding of how.

(2/7)

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This was done by experimenting with isolated mitochondria.

They measured how much energy mitochondria could output and how much oxidative stress they would be under.

To ground, they literally stuck steel wiring into the tubes with the mitochondria, which connected to the ground via copper wiring.

A control group had the wiring but no connection to the ground.

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Read 7 tweets
Aug 30
Bone broth can drastically lower inflammation in the gut, as shown by a recent study.

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The broth in this study was prepared by:

✧ Bone source & prep β†’ Bovine femur bones (100–130 g), cut crosswise, commercially obtained
✧ Cleaning β†’ Washed 3Γ— in distilled water at 50 Β°C for 15 min to remove meat/fat/blood
✧ Cooking setup β†’ Slow cooker, bone-to-water ratio 1:4
✧ Acidified water β†’ 20 mL white vinegar per 1 L distilled water, boiled before adding bones
✧ Cooking process β†’ Simmered 8 h at 100Β°C, volume maintained with acidified water
✧ Post-cooking β†’ Cooled 3 h at room temp, refrigerated 6 h at 4 Β°C
✧ Filtering β†’ Bones and fat removed via funnel with cotton gauze

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Bone broth preserved the structure of the gut.

The two pictures on the top are from the animals with gut inflammation without bone broth.

You can see how the intestines look like they got ripped apart. There's also more immune cells that have infiltrated the area (neutrophils).

The bone broth group on the bottom had nearly normal gut structure, and far less neutrophil infiltration.

All of this indicates a much healthier gut.

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Read 10 tweets
Aug 29
Hair growth can be powerfully stimulated with the right nutrients, as shown by a recent study.

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This study was published in 2023.

It assessed the impact of a mix of:

➜ Hydrolysed fish-origin collagen
➜ Taurine
➜ Cysteine
➜ Methionine
➜ Iron
➜ Selenium

Over 3 months - in people with all types of hair loss conditions, including male pattern baldness.

People either got this mix + a typical hair loss drug, or the drug alone.

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Those taking the nutrients showed subjective hair growth, measured by dermatologists.

Improvements in the global assessment score (GAS) showed improvement at just 6 weeks,

whereas no improvement was seen with drugs alone.

Their hair growth more than doubled at 12 weeks in comparison to drugs alone.

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Read 12 tweets
Aug 29
Cortisol can be completely stopped with a simple & cheap supplement, according to a fascinating study.

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This study was published in 2016, evaluating the anti-stress properties of L-THEANINE.

This is an amino acid found naturally in green tea.

People were given either a mix of:

➠ L-theanine (200 mg)
➠ L-alpha glycerylphosphorylcholine (alpha GPC; 25 mg),
➠ Phosphatidylserine (1 mg)
➠ Micronized chamomile (10 mg)

Or placebo, alongside a cognitive assessment.

While the drink did have these other ingredients, they are far below (<1-10%) their typical dosing - so their impacts were likely small or negligible.

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People consuming the L-Theanine drink reported markedly lower stress within the first hour.

They actually felt less stressed with the L-theanine, than they did prior, even though they were taking this assessment.

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Read 10 tweets
Aug 28
Vitamin B1 (thiamine) megadosing can massively reduce fatigue, in many cases reversing it entirely.

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This study was a small pilot study conducted about a decade ago.

Anywhere from 600-1500 mg of B1 was used, depending on the weight of the patient.

The results were stunning.

10/12 patients had a complete reversal of fatigue.

The other two saw reductions by 50% and 66%.

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What was stunning about this study was that these people did not have thiamine (B1) deficiency,

yet they responded to thiamine megadoses as if they were.

This is likely because measuring the amount of B1 or its active metabolite, TPP, is not sufficient to tell if someone gets enough of it into their cells, where it exerts its effects.

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Read 23 tweets
Aug 26
A new study shows vitamin E can reverse fibrosis, inflammation and fat buildup in the liver.

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This study was published in Cell Medicine earlier this year.

Many studies have already shown that vitamin E has protective effects for the liver,

but this was the longest one to date (96 weeks) investigating this low of a dose of vitamin E - 300 mg of alpha tocopherol (450 IU) per day.

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People receiving the vitamin E had visible improvements in their liver condition.

29.3% of people showed improvement in liver histology (>2X as good as placebo)

25.9% showed reductions in fibrosis - the scarring of the liver (>60% better than placebo)

Reducing fibrosis is HUGE - this is the most dangerous and irreversible part of these conditions.

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Read 9 tweets

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