🧵 Key Terms in Rheumatology — Simplified & Explained ⬇️
Rheumatology is full of terms like synovitis, enthesitis, tenosynovitis, dactylitis.
Let’s break them down in a clear way
1️⃣ Synovitis
= Inflammation of the synovial lining of a joint.
Signs: swelling, warmth, tenderness, ↓ ROM.
Seen in: RA, lupus arthritis, JIA.
Think: “the joint lining is angry.”
@DrAkhilX @IhabFathiSulima #MedTwitter #RheumatTwitter
2️⃣ Enthesitis
= Inflammation at the enthesis (where tendons/ligaments insert into bone).
Common in: Spondyloarthritis (PsA, AS, IBD-arthritis).
Typical sites: Achilles tendon, plantar fascia, costochondral junctions.
Pain is deep, localized, worse with stress.
3️⃣ Tenosynovitis
= Inflammation of the tendon sheath.
Classic example: de Quervain’s at wrist.
Also in RA, lupus, spondyloarthritis, infections (TB).
Feels like “painful sausage around the tendon.”
4️⃣ Dactylitis
= “Sausage digit” → uniform swelling of entire finger/toe.
Due to synovitis + tenosynovitis + enthesitis together.
Seen in: Psoriatic arthritis, reactive arthritis, sarcoidosis, sickle cell disease.
5️⃣ Bursitis
= Inflammation of a bursa (fluid-filled sac cushioning bone/tendon/joint).
Examples:
•Olecranon bursitis (“student’s elbow”)
•Prepatellar bursitis (“housemaid’s knee”)
Can be inflammatory (RA, gout) or infectious.
9️⃣ Raynaud’s Phenomenon
= Reversible color changes of fingers/toes on cold exposure or stress:
White → Blue → Red
Primary (benign) or Secondary (SSc, MCTD, lupus).
🔟 Takeaway
These terms aren’t just jargon.
They describe specific clinical patterns that point directly to diagnosis.
Mastering them = thinking like a rheumatologist 🔎
Share to spread knowledge.
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🧵 Hypercalcemia – A Clinical Approach plus Rheumatological causes:
1/ Hypercalcemia isn’t just “high calcium.”
It can cause kidney stones, bone pain, abdominal symptoms, psychiatric changes – and even cardiac arrest.
Here’s a structured approach 👇
@IhabFathiSulima @DrAkhilX #MedTwitter
2/ 🔎 Step 1 – Confirm
•Correct serum Ca for albumin OR check ionized Ca.
•Rule out lab error.
•Always assess severity & symptoms.
Mild: 10.5–12
Moderate: 12–14
Severe: >14 or symptomatic
1/🧵 Acute Kidney Injury (AKI) is a common but critical problem in Internal Medicine.
Early recognition & classification into Prerenal, Intrinsic, Postrenal is essential for patient outcomes.
Here’s a stepwise approach
@IhabFathiSulima @DrAkhilX #MedTwitter #RheumTwitter #NephroTwitter
2/ 🔹 Definition (KDIGO):
•↑ Serum Creatinine by ≥0.3 mg/dL within 48 hrs OR
•↑ Serum Creatinine to ≥1.5× baseline within 7 days OR
•Urine output <0.5 mL/kg/hr for 6 hrs
1/ Chest pain in rheumatology patients?
Don’t forget Pericarditis — one of the most frequent cardiac manifestations of autoimmune disease.
Here’s a stepwise approach. 🧵
@ihabFathiSulima @DrAkhilX #MedTwitter #RheumTwitter
3/ 💡 Clinical features
•Sharp, pleuritic chest pain → relieved on sitting forward
•Pericardial rub (scratchy sound at LSB)
•Dyspnea if effusion present
•Fever with active inflammation
Renal Tubular Acidosis (RTA) in Autoimmune Diseases:🧵
1/ Not every metabolic acidosis is due to sepsis or renal failure.
In rheumatology, think Renal Tubular Acidosis (RTA) — a subtle but important clue to underlying autoimmune disease. @IhabFathiSulima @DrAkhilX #MedTwitter #RheumTwitter #NephroTwitter
2/ 🔹 What is RTA?
A defect in renal acid handling → normal anion gap metabolic acidosis with preserved GFR.
Types:
•Type 1 (Distal)
•Type 2 (Proximal)
•Type 4 (Hypoaldosteronism-related)
🧵 Liver & Autoimmune Diseases (AIH, PBC and PSC): 1/ When the immune system attacks the liver or bile ducts, 3 classic conditions come to mind:
•Autoimmune Hepatitis (AIH)
•Primary Biliary Cholangitis (PBC)
•Primary Sclerosing Cholangitis (PSC)
Let’s walk through them 👇 @IhabFathiSulima @DrAkhilX @Janetbirdope @theliverdr @drkeithsiau @Gastronaut___ @NatRevGastroHep #MedTwitter #Hepatology #GastroTwitter
2/ 📌 Autoimmune Hepatitis (AIH)
•Mostly affects young women
•Symptoms: fatigue, jaundice
•Labs: very high AST/ALT, ↑IgG
•Autoantibodies: ANA, SMA, anti-LKM
Untreated → cirrhosis in a few years.
3/ 💊 AIH Treatment
•Start with steroids
•Add azathioprine for long-term control
•Budesonide in select non-cirrhotic patients
•Monitor enzymes + IgG
Relapse is common if stopped early.