Michael Morelli Profile picture
Sep 14, 2025 18 tweets 6 min read Read on X
Your mitochondria predict your death date.

10,000+ studies confirm that dysfunction triggers cancer, heart failure, and 300+ other diseases.

Here’s the protocol to restore your mitochondria at any age (based on science):🧵
Let’s start with the signs your mitochondria are dying:

1. Constant fatigue (especially 3pm crashes)
2. Waking up tired despite 8+ hours of sleep
3. Brain fog and poor mental clarity
4. Feeling cold all the time
5. Slow recovery from exercise

If this sounds like you, keep reading...
Mitochondria are organelles inside every cell that convert food and oxygen into ATP, your cellular energy currency, through the *Krebs cycle.

(*A chain of reactions that extracts energy from carbs, fats, and proteins).

Without them, you literally can’t breathe, move, or think:
Modern life destroys mitochondria faster than your body can repair them.

So let’s go deeper into what silently kills them every day.

1. Ultra-processed foods (+ overeating)
They create massive oxidative stress at the cellular level.

(This means free radicals build up and damage your cells faster than your body can repair them.)

PS. Even too many calories from “healthy” food can overwhelm your system when blood glucose and insulin spike repeatedly:
2. Sitting for hours

It reduces mitophagy, your body’s cellular cleanup process.

This lets damaged mitochondria build up in your system.

Low activity stops your cells from clearing debris that leaves you tired. Image
3+4. Chronic stress + Poor sleep

Chronic stress elevates cortisol and blocks mitochondrial repair.

Poor or irregular sleep disrupts the circadian rhythm that controls mitochondrial function.

Your cells can’t repair when stress hormones stay elevated all day and night:
5. Toxins

Heavy metals, mold, pesticides, and chemicals build up in your body fat over time.

When you lose weight, they flood your bloodstream and overwhelm mitochondria: Image
If you want to uncover cellular damage, you need proper bloodwork.

Key markers to check:
• Elevated inflammation (CRP, fibrinogen, platelet-to-lymphocyte ratio)
• Albumin outside the optimal range → oxidative stress
• Poor glucose control → metabolic dysfunction
• High white cell count → active infectionImage
+ Advanced testing goes deeper.

Organic acid tests measure Krebs cycle function directly.

A high lactic-to-pyruvic ratio signals mitochondrial dysfunction.

These tests reveal energy problems that standard blood panels completely miss.
Now let’s see how you can start healing your mitochondria.

Critical nutrients they need are B-vitamins (B1, B2, B3, B5, B9, B12), magnesium, zinc, CoQ10, and vitamin D.

Most people are deficient in these basics (& wonder why they’re exhausted):
2. Foods that support mitochondrial health:

• Leafy greens provide nutrients without insulin spikes
• Fatty fish rich in omega-3s for membrane health
• Nuts and seeds for healthy fats
• Berries loaded with antioxidants

Real food over processed alternatives (your mitochondria can tell the difference):Image
3. Lifestyle practices that enhance mitochondrial function:

• Intermittent fasting (triggers mitophagy, cellular cleanup)
• Heat exposure like saunas (creates beneficial stress)
• Cold therapy (forces adaptation and new mitochondria creation)
• HIIT training (builds more cellular powerhouses)
• Regular movement throughout the day

(Bookmark this, it will save your life)Image
⚠️ Important note ⚠️

→ Learn about the gut–mitochondria connection.

If you have gas, bloating, or reflux, you’re not absorbing the nutrients your mitochondria need.

Digestive dysfunction must be fixed first before mitochondrial optimization can work:
Reversing years of cellular damage takes 6-12 months minimum.

It requires a methodical approach guided by testing, not guesswork.

But healthy mitochondria mean decades of better energy, mental clarity, and disease resistance.
1 in 2 people have damaged mitochondria.

Have you ever felt any dysfunction signs?
If you found this thread valuable and want more on becoming superhuman…

1. Like and retweet the first post
2. Follow me @morellifit for more

See you in the next one !
I’ve helped 1000s build their dream physique & overcome diseases they thought were impossible to fix.

All through:
• 124 biomarker test (reveals health data)
• 80-page lab breakdown
• Expert analysis & support

DM me "DATA" & we’ll show you how to start.

x.com/messages/compo…Image

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More from @morellifit

Feb 8
Your doctor will never tell you this…

But these 9 biomarkers show why you can’t lose fat and keep gaining weight no matter what you try:

1. Fasting Insulin → Fat Storage Signal Image
High fasting insulin means your body stays in fat-storage mode (even when you're eating less)

When insulin is chronically elevated, fat burning becomes biologically impossible. Image
2. HOMA-IR → Insulin Resistance Severity

This shows how resistant your cells are to insulin.

High HOMA-IR = glucose can’t enter cells → insulin stays high → fat stays on.

Most “diet failures” are insulin resistance problems.
Read 13 tweets
Feb 3
Standard labs miss what kills you.

Here are the 9 biomarkers that predict lifespan, disease risk & how your body ages:

1. ApoB (True Heart Disease Risk) Image
Standard cholesterol tests measure LDL.

But ApoB measures the actual number of atherogenic particles in your blood.

High ApoB = high cardiovascular risk, even if your LDL looks "normal."

This is the number that actually predicts heart attacks. Image
2. hs-CRP → Chronic Inflammation

hs-CRP (high-sensitivity C-reactive protein) measures systemic inflammation.

Chronic inflammation drives heart disease, cancer, diabetes & neurodegeneration.

If your hs-CRP is elevated, your body is under constant inflammatory stress (even if you feel fine)Image
Read 13 tweets
Jan 22
I saved my brother’s life.

He was obese, had chest pains & our mother thought we were losing him.

So I moved in with him & helped him drop 52 lbs in 90 days (steal the exact protocol): Image
The first and most important thing you need to focus on to lose weight?

Your diet.

The meal plan we used:
⤑ 3 meals a day, spaced 5 hours apart.

PS. We ate whole foods, stayed in a deficit & never mixed fats with carbs:
For lunch, we kept it simple:

• Lean protein (salmon, chicken +)
• Veggies (broccoli, sweet potato, etc.)
• Healthy fats (avocado, eggs, etc.)

Dinner looked like this:
• Lean meats
• More veggies
• Clean carbs (fruit, sweet potato, etc.)

The goal was fat loss without starving or burning out (something all of you need to copy):
Read 13 tweets
Jan 19
I’ve been testing peptides for over 5 years...

So here are the top 5 fat-loss peptides that helped me get more shredded than your favorite Hollywood star at 44:

1.Retatrutide Image
A next-generation peptide that targets three hormones (GLP-1, GIP & glucagon) at the same time.

It helps reduce hunger, improves blood sugar control & increases fat burning.

Phase 3 trials showed up to ~28% bodyweight loss (one of the highest results ever recorded in obesity treatment):
With Retatrutide (0.6mg every other day, guided by labs), I went from 178.7 lbs at 11.9% body fat to 172.8 lbs at 7.2% (dropping ~9 lbs of fat while gaining 1.5 lbs of muscle)

With no starving or suffering: Image
Read 10 tweets
Jan 7
If you’re overweight and want to lose belly fat in 2026…

Here’s the exact 11-step protocol to drop 20+ lbs in 90 days (without starving):

Step 1: The 3x5 Diet
3 meals per day. 5 hours apart. No snacking.

Breakfast + lunch: protein, veggies, fats (no carbs).
Dinner: protein, veggies, carbs (no fats).

Avoid fats and carbs in the same meal (this helps prevent insulin spikes that lead to fat storage).
Step 2: Protein First (Always)

Protein keeps you full longer.

When you eat protein first, then veggies, then fats or carbs last, you naturally eat less without forcing it.

PS: Aim for 1g of protein per pound of bodyweight per day.
Read 13 tweets
Dec 28, 2025
In 2025 you ate 40+ credit cards worth of plastic.

These microplastics sit inside your body (heart, brain, testicles) & are linked to 10+ deadly diseases.

In this thread, I'll show you the only proven ways to detox them & how to avoid the hidden sources you're exposed to daily:
Microplastics have been linked to 20+ diseases – including cancer, 4–5× higher heart attack risk, and gut–brain damage.

Around 80% of us are already contaminated, so let’s start with the best way to stay safe: lifestyle changes (then we’ll cover how to detox a portion of them):
Of course, you avoid the obvious ones:
• Plastic cutting boards
• Plastic bottles
• Glass bottles (yes, they can contain microplastics too – read till the end to see how)
• Plastic coffee cups
• Plastic Tupperware
• Teflon pans

But the goal of this post is to expose the sneaky sources most people miss – so let’s get into it:
Read 17 tweets

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