AJ Leonardi, MBBS, PhD Profile picture
Sep 17 2 tweets 3 min read Read on X
NIH RECOVER has found that incidence of long covid for infections in 2023 and 2024 has not been decreasing since 2021 and in fact, may steadily be increasing!

academic.oup.com/cid/article-ab…

This is despite assurances from Zeynep that 'novelty was severity' and Dr. Akiko Iwasaki saying:

"immunologically it's unlikely that you're going to develop long covid after a second or third infection because you've already developed some levels of immune responses"
x.com/zeynep/status/…

"Top notch" analysis from experts like Zeynep claims, means nothing if they cannot use that information to understand and predict.

This is a failed analysis because immune responses do not equate to competent and effectual immunity, something that I have been shouting to individuals that seek to merely enumerate T cell reactivity following infection.

I was accused of lacking nuance and alarmism for claiming
1) covid harms the t cell arm of immunity
and
2) covid was intrinsically severe and I expected immune responses to decay with time

It seems as though others lacked nuance in their assessments. Also, doesn't the increasing trend of long covid incidence suggest there could be an effect from immune harm or growing immune incompetence?

Trust me, I am aware of the seniority of the individuals that I am calling out. Do you know how many times these people, despite being way off the mark, have used their positions as data collectors to assuage the public, have been awarded and courted by the National Academies of Science? The award is for saying the politically palatable thing.

academic.oup.com/cid/article-ab…Image
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@statsepi I see you deleted your original post where you said reinfections would result in a decreasing rate of long covid.

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More from @fitterhappierAJ

Jun 22, 2024
@Bryce_Nickels This is absolutely false because he made a “noble lie” and said the N 95s would not work for the public to the public in order for there to be greater supply to healthcare workers only. This backfired.
@Bryce_Nickels The ethical approach was the truth. This is a similar noble lie by omission that the WHO made when they refused to declare Covid as airborne in order for impoverished health systems to provide “adequate” PPE per their regulations according to WHO standards
@Bryce_Nickels The end result was workers in impoverished systems were being given “adequate “PPE for droplet transmission, and many of them died, including sadly many in New York City.
Read 4 tweets
Apr 6, 2024
When will H5N1 will go Human to Human?
Which is deadlier?
"The Covid pandemic has prepared me for an H5N1 pandemic"
Read 4 tweets
Mar 30, 2024
Wow looks like Marc is advocating Zero Covid, welcome Marc!

Mitigations like mask-wearing, clean air, and acknowledging the harm of covid infections

Well done!

This is an advancement from saying infections will maintain immunity, advocating for infection prevention instead Image
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Although it is a falsehood that vaccintions will not be needed

SARS Cov 2 is a Sarbecovirus and unlike the other common cold viruses. It has enhanced pathogenicity and immune evasion

Also, endemic sars cov 2 would INFECT the vulnerable, not protect them Image
I sure hope people didn't listen and abandon vaccinations after 1 infection because they thought reinfections would be like a common cold!
Read 5 tweets
Mar 29, 2024
I think the decrease in childrens performance following 2020 was due to the Neurological harm after they were coaxed into unsafe classrooms before vaccination

I think this will remain the dominant effect due to Covid's neurotropism on reinfection

theconversation.com/mounting-resea…
Some people are encouraged to obfuscate the risk of kids getting infected and they will continue to do so


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16.1% of reinfected children got Long covid after reinfection compared to 12.1% with only 1 infection

More reinfected individuals had persistent anosmia, an indicator of neuroinflammation
ncbi.nlm.nih.gov/pmc/articles/P…
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Read 4 tweets
Jan 26, 2024
I was a fellow at the National Cancer Institute for 4 years in immunotherapy of cancer

They paid for my PhD

I am happy to explain hypotheses for a potential SARS Cov 2 based increased risk of cancer:

1/4
There are multiple ways a virus can cause cancer directly & indirectly

One indirect way is by tempering immunity

The immune system surveils for wayward, cancerous, and precancerous cells, and kills them

SARS Cov 2 ages & dysregulates T cells
2/4
A second broad yet direct category is by Viral Oncogenes or mutagenesis

Some Viruses have proteins that can change expression or function of host genes & accelerate the formation of tumors by preventing cell death

Some viruses cause DNA errors to accumulate
3/4
Read 5 tweets
Jan 24, 2024
In 2021 on TWIV, Vincent Raccaniello said my claims of T cell exhaustion risk were "Twitter Science™"

In 2024 I am pleased to see T cell exhaustion is Science™, Nature Immunology™, and Nature Medicine™ Science
Raccaniello is arrogant enough to the extent to reject an accurate scientific hypothesis on twitter and his TWIV podcast to the detriment of the public, without knowing enough about the subject It was completely irresponsible

Are you feigning ignorance? It was a perjorative.
Read 10 tweets

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