Thread by @Outdoctrination

Raw milk might be able to keep the brain young, sharp and healthy, even in small amounts.

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Studies have investigated the impact of a peptide mix called colostrinin on the brain.

Colostrinin is a fraction of the protein from colostrum, or first milk.

In this paper, it was used at :

➜ 100 μg every other day
➜ 3 weeks on then 2 weeks off
➜ Total of 15 weeks
➜ Patients with existing Alzheimer's

You'll get that much in a few sips of raw milk, even less of colostrum.

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The milk peptides substantially slowed the rate of cognitive decline substantially.

While people taking placebo in phase 1 (first 15 weeks) had their Alzheimer's worsen by about 19%,

those taking colostrinin remained essentially the same.

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People taking colostrinin also had improved quality of life.

They rated no change in their impairments in daily life (IADL),

meanwhile those in placebo reported worsening.

There was a similar trend for their cognitive assessment, though this was not "statistically significant."

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These milk derived peptides have some striking protective effects.

What you're seeing here is markers of induced cell death without (left) and with (right) colostrinin in brain cells.

See the cell death on the right?

Yeah, me neither.

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Colostrinin impacts tons of genes involved in brain health.

A transcriptomic study looked at all of the genes that colostrinin impacted.

Green = downregulated, so basically this is showing that there were decreases in GLUTAMATE signaling.

Excessive glutamate drives excitotoxicity which is a core feature of cognitive decline.

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The raw milk peptides also:

◇ Downregulated amyloid peptide production (plaques, highly relevant in Alzheimer's)
◇ Decreased PKA (tau hyperphosphorylation, also highly relevant)

While other studies showed decreased inflammation - here massively reducing nitric oxide output.

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