Sasha Gusev Profile picture
Sep 18 24 tweets 9 min read Read on X
Murray and most of race twitter has apparently been fooled by this completely fabricated analysis purporting to show African ancestry is associated with IQ. People lie on twitter all the time, but this is both more revealing and more disturbing than usual. A 🧵
Revealing in that it shows how quantitative racism is a just an exercise in manipulating data to fit the preconceived conclusion. Disturbing because this time private data is being used and the results, which cannot be easily verified, are just flatly invented.
What's actually going on? Some guy claims to have an analysis showing that African ancestry differences between siblings are associated with IQ differences in the UK Biobank. Implying an ancestry difference in the within-family influences. Image
But there's an obvious glaring error: in the same analysis, African ancestry was *not* associated with darker skin! Which would mean ancestry-specific alleles DO NOT have a direct influence on skin color. Pigment is, according to these guys, a social construct. Image
We, of course, know that alleles influencing pigment differ across populations, and that more African admixture is associated with darker pigment. Anyone honestly looking at this result would realize something went wrong and try to debug it. But not this crack squad.
Instead, the result is forced to fit the narrative. We get a whole wall of text about how sparse traits like skin color won't actually correlate with African admixture. This makes zero sense. And you'll notice the model is never actually derived, just argued on faith. Image
When we look in papers that actually derive a model (), we can see that the derivation does not depend on sparsity at all. The analysis estimates the difference in direct genetic values regardless of the trait architecture. medrxiv.org/content/10.110…Image
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Or we can use our intuition: for a sparse trait, siblings will either have no trait differences or very large differences; for a non-sparse trait, siblings will often have small trait differences -- it's a wash. Sparsity impacts the variance and not the estimate.
Or we can just simulate it (): generate admixed families with a heritable trait that has allelic differences between populations, and confirm that the sibling analysis accurately recovers the true difference. It does! Regardless of sparsity. gist.github.com/sashagusev/b92…Image
So the analysis is clearly bogus from theory, intuition, or simulation. Why invent a ridiculous explanation for it? Because the fake result is *useful*. If ancestry doesn't impact skin darkness, then one can claim that 'colorism' is not a relevant mediating factor.
One other point you might notice in the simulation is it takes tens of thousands of siblings to get an accurate estimate. Within-family ancestry variance is low, and so the number of families needed for statistical power is very high. This is also a well known result.
The recent Wang et al. analysis used ~17,000 siblings with more ancestry variance and still had a standard error of ~0.25. Earlier, the blogger gwern ran power calculations and came to a similar conclusion (): gwern.net/note/statistic…Image
The UK Biobank analysis purports to have a much tighter standard error (~0.13) so how many sibling pairs did they use? Hundreds of thousands? Nope ... 175! That's right. They looked at 175 families and concluded that racism is real once and for all. Image
At this point it should be clear that we're dealing with complete bullshit. For the interested, a longer discussion (), with multiple derivations coming to the same conclusion. The accounts behind the analysis don't even bother to respond. Image
I'm belaboring the point is because it is endemic of the broader quantitative racism project: find data that fits the narrative, fake it if necessary, and when someone finally points out the errors, the time for argument is past and we move on to a new spectacular claim. Image
First, it was individual candidate genes that had massive influences on behavior and cognition. When these failed to replicate spectacularly, the excuse was that the *theory* still made sense (ironically, this claim was recently deleted!).

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Then it was the claim that heritability estimates themselves could be manipulated to prove the genetic differences between groups. When this was mathematically disproven (), suddenly people like Murray lack the rigor to evaluate it. pubmed.ncbi.nlm.nih.gov/38470926/Image
Then it was the claim (borrowed from Jensen) that IQ tests cannot be driven by culture because more g-loaded subsets are more "culture free". When this too was shown empirically to be the exact opposite of the truth ... crickets.

Then it was the claim that genetic scores for IQ are lower in African samples. When a proper analysis revealed the results to be completely *flipped*, this did not lead to a sudden interest in African genius -- the earlier claim was simply forgotten.

Then it was the claim that admixture correlates with IQ. When this too was pointed out to be environmentally confounded, lo and behold: a set of 175 sibling pairs was immediately identified and manipulated to make a bold new result. And here we are.

In each instance, the goal was not to get at some underlying truth, but to add more bullshit to the conversation faster than careful people can refute it. Create the appearance that the prophecy is always coming true but ~they~ are hiding it from you.

Coming back to Murray and Jensen. Murray, frankly, should know better. But at this point he's basically a victim of elder abuse: high-tech scams that he himself does not even pretend to understand and merely echoes because they fit the narrative he spent his life cultivating.
Jensen, for all his ugliness, at least attempted to do research. He went out into the field and collected data and tried to report the results. But this new generation of Jensen-ites is different: truth is irrelevant, they can simply put on the performance of doing research ...
... grabbing data, forcing it to fit, constructing elaborate epicycles to explain inconvenient results, then abandoning them as convenient.

And now that multiple rounds of these pseudo-analyses have resulted in failure, they've finally graduated to ... just making shit up. /x

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More from @SashaGusevPosts

Aug 1
A few thoughts on Herasight, the new embryo selection company. First, the post below and the white paper imply that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵
I wrote last year about the un-seriousness with which Nucleus approached their IQ product and the damage it could do to genetic prediction and research more broadly (). This appears to have been a broader pattern beyond IQ, extending even to rare disease.theinfinitesimal.substack.com/p/genomic-pred…
People who care about this technology should be furious at Nucleus and their collaborators (as well as Orchid and Genomic Prediction for their own errors). Finding such flaws should not require reverse-engineering by a competitor. These products clearly need independent audits. Image
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Read 14 tweets
Jun 24
Oof. Polygenic scores for IQ lose 75% of their explained variance when adding family controls, even worse than the attenuation for Educational Attainment. These are the scores Silicon Valley is using to select embryos 😬.

A few thoughts on this study ...
The TEDS cohort used here is a very large study with high-quality cognitive assessments collected over multiple time points. It is probably the most impressive twin study of IQ to date. That means very little room for data quality / measurement error issues.
It is important to highlight surprising null results. Just last week we were hypothesizing that large IQ score attenuation could be a study bias or an artifact of the Wilson Effect. Now we see it replicate in an independent study with adults.

Read 12 tweets
Jun 11
Racism twitter has taken to arguing that observed racial differences must be "in part" explained by genetic differences, though they demure on how much. Not only is this claim aggressively misleading, it is completely unsupported by data. A 🧵: Image
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Genetic differences between any two populations can go in *either* direction, matching the phenotypic differences we observe or going against them. Genes also interact with the environment, which makes the whole notion of "explaining" differences intractable. Image
The mere fact that a trait is heritable within populations tells us nothing about the explanatory factors between populations. See: Lewontin's thought experiment; Freddie de Boer's analogy to a "jumping contest"; or actual derivations (). pubmed.ncbi.nlm.nih.gov/38470926/Image
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Read 13 tweets
Jun 6
James Lee and @DamienMorris have an interesting perspective paper out describing "some far-reaching conclusions" about the genetics of intelligence. This type of "where are we now" paper is very fun and more people should write them! So, where are we now? 🧵 Image
It's a short paper and it surveys three core findings from the past decade of intelligence genetics. These sections follow a structure that I would cheekily call ... "make a bold claim in the title, then walk it back in the text".
First up, they address the concern that associations with intelligence may actually be mediated by functionally irrelevant traits like physical appearance or pigment. The argument is that IQ GWAS has demonstrated enrichments for CNS/brain structure gene sets. This is true! Image
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Read 19 tweets
May 20
The SAT/meritocracy debate has always been a bit odd to me when the test makers themselves have studies showing self-reported high-school GPA is a consistently better predictor of college GPA and always adds on top of SATs. Image
Clearly SATs are neither the only nor even the best measure we have of college success and "holistic" admissions can be "meritocratic". It's up for debate whether the additional <10% predictive variance SATs give you are worth the high-school testing industrial complex.
A challenge with all of these analyses is they are measured after selection on the predictor variables themselves, which can induce biased estimates through range restriction. The raw correlations are even lower, and it is hard to know whether correcting is appropriate. Image
Read 5 tweets
May 11
Hanania advocated passionately against "race mixing" for years, so he knows what he's talking about here. But it's worth adding that race-IQ obsessives also tend to make very poor predictions about the future. Let's review ...
The Bell Curve, published at the peak of the 80-90's crime wave, predicted a coming dystopian urban hellscape with a "cognitive underclass" living in state-managed facilities. Not only did all this fail to materialize, but crime rates collapsed.

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Charles Murray has nevertheless spent the following 30 years predicting vindication for his claims was just around the corner ... each time pointing to a new corner.

Read 11 tweets

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