Thread by @DrJackKruse

You see what Dr. Grimm sees in this paper, but what do I see in this paper?

This answers, definitively the question I posed to Huberman on the Tetragrammaton podcast, that the KT event drove internalization of melanin in eutherian mammals but not so much in birds. Perioxisomes burn fat and release UPEs. See the slide below in #7 and 18. That is the real story here. Light sculpted many changes with a rejection of chromophores in eutherians mammals and push for endothermy that lead to optimaization of the leptin melanocortin pathways.

Expanded Biophoton Sources: Explosion Post K-T

My list of 20 intracellular biophoton sources (e.g., NADH/NADPH, ROS, mitochondrial chain, melanin) shows an "explosion" post K-T, driven by adaptations like mitochondrial/peroxisomal amplification and melanocortin internalization.

This Fits ideally into my photobiolelectric thesis. Post K-T event we had a surge of changes that lead to more UPE creation: Reduced external UV forced internal UPE reliance, with sources like peroxisomal oxidation adding to mitochondrial ROS.

This ties to leptin-melanocortin (e.g., melanin in pigment cells emitting UPEs), myelin (membrane potential changes triggering UPEs), and quantum endothermy (IR as biophotons structuring water). The list expands our UPE narrative: post K-T, mammals/birds amplified endogenous light for signaling, reducing entropy via Shannon's theorem, enabling complex behaviors and longevity (e.g., human fur loss for more UV-to-UPE conversion). I see targets that others do not even know are there.

2. What were the only two animals that made is past the 5th extinction? Therapod dinosaurs became birds and eutherian mammals became humans.

Differences as Adaptations:

Birds' higher temperature/metabolic rate suits flight, while mammals' BAT-focused NST (with peroxisome augmentation) emphasized grounded endurance underground.

The unappreciated metric, quantum-tuned endothermy, directly affected endogenous water chemistry in cells, as IR from both mitochondria/peroxisomes structures cytoplasmic water, enhancing coherence for UPE signaling. This was a critical step in evolutionary history of the mammals post KT.

3. What was the key in eutherian mammals? Innovating a placenta from HERV retrotransposons to build a placenta that had nuclear weapon capability to build complex life because the placenta are the major way eutherians make UPEs. That should raise the question in your mind, what drove placenta; growth in eutherians? My Brain Gut series covered that 15 years ago.

4. After my Factor X webinar which discussed the KT event, people learned that the currency of survival for all eutherian mammals was a new biologic strategy to speed up DNA expression to adapt more quickly to the environment. UPEs are how they accomplished this task.

The reasons eutherian mammals survived is because they use a placenta to birth their young. There is now strong evidence from molecular biology that the genes that coded for the evolution of the placenta were heavily selected for after the K-T event.

How do we know this?

The first mammals were rather old in an evolutionary scale, about 210 x 10 to the 6th years before the present time (YBP). These early mammals (such as multituberculates) were small, furry, egg-laying, monotreme-like insect predators. They were present prior to the advent of the dinosaurs, but became extinct about 35 x 10 to the 6th YBP.

We know nothing about their molecular genomes, but what we do know, is that two other mammalian lines developed from them directly, the marsupials and the eutharian placentals. Humans are in the later class.

How do we know placenta were heavily selected by a post K-T world? Well, the marsupials are only found in the southern hemisphere with the few exceptions. This fits perfectly with how Factor X occurred 66 million years ago as well as I laid out in my Webinar. Moreover, the placental mammals were far more successful because they radiated over 2000 genera, to about only 140 genera in the marsupial clade.

Most of the surviving species left on the land of this planet is due to that formative moment in evolution. This is a big step in knowing who we really are and how we are built. Factor X (KT Event) is huge history story one must know for any mammal that evolved after it to explain why biology is what it is.

How does viral marketing, CT, Factor X, and CT-6 all come together for Homo’s solution?

Here is the most important fact in all of mammalian evolution in my opinion that is not talked about enough. With these placental mammals, we see clear and compelling patterns of acquisition of genetic parasitic elements in their genomes, mainly in the context of retroviruses like LINES, SINES, and ERVS.

After K-T the best source of food was located in the deep polar seas with its huge collection of marine life and cauldron of viral particles as we covered in Brain Gut 2. The predominate macronutrient in the sea is seafood/microalgae.

This means that all the animals left on our planet at some point after the K-T event would of had their food supply mostly tied to the ocean as some point.

It was also bitter cold for many years after a sudden global event like K-T impact. This induced PPAR and mitochondria adaptation of quantum endothermy.

What would life do in this case like this? It would have to evolve to that environment rapidly and that is precisely what happened to our deepest ancestors by using viral marketing as laid out in Brain Gut 2.

That program is wired into the neural structures of every surviving animal left on the planet. This was my thought process when I was thinking about finding the Ancient Pathway in the mammalian brain I laid out in CT-6 blog post. I think it is no coincidence that eutherian mammals 66 million years ago and modern man 13,000 years ago had to navigate the same freezing environment and survive. Clearly, this ancient program was wired into the mammalian nervous system for a deep evolutionary reason.

Let us now fast forward to 2.6 million years ago where our recent ancestors come from, the transitional apes. I have already showed you in Parts 1-3 of the Brain gut series that primates and humans use massive amounts of these transposable genetic elements to create new genes to adapt quickly by using UPEs as their fuel source to complete the task.

Evolution uses a fractal design where form always meets function, of course, and we did the very same thing again in our speciation as life did after the K-T event.

5. There is now an abundance of evidence that during embryogenesis and organogenesis, the development of the human placenta is supported by histotrophic nutrition secreted from endometrial glands rather than maternal blood. This means that circadian clock mismanagent of the uterus is one of the keys in creating transgenerational epigenetic diseases. See the slide. These secretions provide a plentiful supply of glucose, lipids, glycoproteins and growth factors that stimulate rapid proliferation and differentiation of the villous trophoblast.

I have already showed you in Parts 1-3 of the Brain gut series that primates and humans use massive amounts of these transposable genetic elements to create new genes to adapt quickly by using UPEs as their fuel source to complete the task of editting out ill fitting nuclear DNA damage to create a new life. The placenta is the ultimate organ in the photorepair process. Evolution uses a fractal design where form always meets function, of course, and we did the very same thing again in our speciation as life did after the K-T event with the eutherian placenta leading the way. Light has always sculpted life this way. UPEs are the light that completes that task.

6. Just how important is keeping the lining of the uterus clean from circadian damage or from spike protein infiltration? It determines more about your kid than your DNA does because it makes the UPEs that sculpt the nuclear genes that comprimise your kid.

The human placenta is unique in many ways. It is the first and the largest fetal organ to develop and during early pregnancy performs the functions of diverse organ systems while these differentiate and mature in utero. Furthermore, the placenta undergoes major changes in its own structure and function during gestation while providing constant support for the growing fetus.
Immunologically, it is interposed between two genetically related, but different, individuals, the only situation in mammals where this is tolerated.

7. Recent advances in fields as diverse as molecular phylogenetics, genomic imprinting and medical imaging have revolutionized our understanding of the evolution and physiology of the organ, challenging many dogmas held since the nineteenth and twentieth centuries.

At the same time, it has become apparent that the influence of the placenta extends beyond the embryonic/fetal period, and that its functions lay the foundation for life-long health of both the offspring and mother.

Thus, aberrant placentation not only has immediate consequences for the outcome of a pregnancy, but also predisposes the offspring to metabolic, cardiovascular and neuropsychiatric disorders and certain cancers in adult life due to structural and epigenetic changes in organ systems. These findings have demonstrated that abnormal placentation has its pathophysiological roots in the earliest stages of development from the time of implantation onwards, and possibly, as recent evidence suggests, even in the preparation of the uterus preconceptionally. THAT IS HOW POWERFUL THE UPE LIGHT OF THE PLACENTA IS.

8. What else do we need to build a human brain when the placenta is optimized?

a. Iodine from the marine chain

b. Iron for heme protein construction to product us from an oxygen halocaust

c. A placenta that is capable of creating a massive fat furnace to fuel to release STAR like UPEs that has the perfect mix of 03 DHA to 06 EPA to make the initial neural framework manifest inside the cranium.

d. Lots of oxygen to complete the desaturation converting shorter chain to long chain PUFA’s: DHA requires 6 O2 molecules. This is why previous to the Cambrian explosion we have no ‘big brained’ animals in the fossil record. We had no oxygen to fuel a brain’s growth. When O2 showed up life exploded.

e. Efficient mitochondria carry out the oxidative metabolism and lots of them in the brain.

f. Phospholipids and the special chemistry of lipids in aqueous milieu (brain and spinal cord sit in a bag of CSF fluid) to create more unique UPE spectra to build things never seen in evolutionary history before.

g. Cell membranes respond to diet, temperature and to pressure changes epigenetically. Since humans are homeothermic, our neural lipid epigenetic variables are diet and environment dependent. These features allow biochemistry to specifically affect the acyl groups on our lipid layers in the brain for optimal cell signaling.

You might be a great biochemist or organic chemist but if you do not know neural biochemistry you might not be aware of just how much you do not know.

Proteins receptors are inserted in these special lipids to signal cells chemically and electrically. This means lipid rafts in the CNS of man have to contain unique proteins have to be multidimensional in configuration and must thermodynamically matched to the lipids in our membranes. DHA is that “magic lipid” that does all of these functions and it is why it has not been replaced one time in the evolution of brains since the Cambrian explosion. You don’t find that information in fossils or in bones on the land.

9. It has long been known that the placenta is different from other human organs. In one to two per cent of pregnancies, some placental cells have a different number of chromosomes to cells in the fetus which is normally considered a genetic flaw in centralized biology that could be fatal to the fetus, but with which the placenta often functions reasonably normally.

Despite the placenta genetic robustness, problems with the placenta are a major cause of harm to the mother and unborn child, such as growth restriction or even stillbirths. My theory, a photobioleelctric theory of life makes sense of all these pardox to make sense.

Consider the 2021 study where they completed a first high-resolution survey of the genomic architecture of the human placenta. Scientists at the Wellcome Sanger Institute and the University of Cambridge conducted whole genome sequencing of 86 biopsies and 106 microdissections from 42 placentas**, with samples taken from different areas of each organ.

The team discovered that each one of these biopsies was a genetically distinct ‘clonal expansion’ which means a cell population descended from a single common ancestor. This finding indicates a clear parallel between the formation of the human placenta and the development of a cancer. This is exactly what my thesis has laid out on Patreon. Patreon.com/DrJackKruse

Analysis also identified specific patterns of mutation that are commonly found in childhood cancers, such as neuroblastoma and rhabdomyosarcoma, with an even higher number of these mutations in the placenta than in the cancers themselves. This peels back how these cancers form via transgenerational epigenetic defects in mom and dad.

10. This thread teaches you an in depth lesson on how the leptin melanocortin pathways evolved from our integuments to our interiors.

Chromatophores, common in pre-K-T reptiles and early mammals, were energetically expensive in a low-UV world post asteroid impact.

Eutherians streamlined to melanocytes, conserving energy for thermogenesis and prioritizing survival over spectacle. This aligned with post-K-T food shifts to marine sources (seafood/algae rich in DHA, iodine, BCAAs), where viral particles in seas provided genetic material for rapid innovation, and the HERV genes build organs like the placenta and hemiflusome to fat burn to create massive UPEs light used to sculpt new eutherians rapidly echoing the "viral marketing" from my Brain Gut series of blogs.

jackkruse.com/brain-gut-3-lo…