The power of coconut oil lies in its medium chain fats.
These fats are able to bypass the regulatory step of a protein called CPT1, which normally slows down the burning of fat in the mitochondria.
Medium chain fats instead go right in with no resistance, meaning they easily get burned for energy and almost never get stored as fat.
It's important to note that not every study in humans has shown this benefit - but it's popped up enough in human + animal studies, and is corroborated mechanistically + anecdotally, to support its power.
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Vitamin B1 (thiamine) megadosing can massively reduce fatigue, in many cases reversing it entirely.
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This first study was a small pilot study conducted about a decade ago.
Anywhere from 600-1500 mg of B1 was used, depending on the weight of the patient.
The results were stunning.
10/12 patients had a complete reversal of fatigue.
The other two saw reductions by 50% and 66%.
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What was stunning about this study was that these people did not have thiamine (B1) deficiency,
yet they responded to thiamine megadoses as if they were.
This is likely because measuring the amount of B1 or its active metabolite, TPP, is not sufficient to tell if someone gets enough of it into their cells, where it exerts its effects.
Iron can actually SHORTEN your lifespan and age you on a cellular level.
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This study was published in 2024, investigating the effects of iron chelation on age related parameters.
They used a common aging animal model - a Klotho knockout animal.
Animals are known to have shorter lifespans without this gene, and longer lifespans with more of it.
They gave them a drug called deferiprone, which binds up free iron and gets rid of it.
What exactly does klotho do?
Well it's main function is a co-receptor for FGF proteins, which govern various metabolic functions (fat burning, glucose uptake, etc.) as well as vitamin D synthesis.
But it also shows a number of other anti-aging effects:
N-acetylcysteine (NAC) was shown to reverse brain damage from aluminum in a critical study.
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Animals were put into 6 groups - either getting aluminum or NAC or both.
The aluminum was administered as aluminum chloride, and it was done so orally.
This is important because roughly only 0.5% of oral aluminum chloride is absorbed, so the real effective doses the animals received were far less than than the 100 mg / kg.
This is still a high dose, but aluminum is known to accumulate in tissues.
Animals had severely impaired memory performance with the aluminum, but this was improved with NAC.
The morris water test trains rats to find a hidden platform in pool.
The latencies (times) is how long it takes to find it on a given day.
Less time = better memory.
As you can see, the high dose NAC almost completely reversed the memory impairment from aluminum.