How many savages know that use of tylenol cause destruction of endogenous glutathione recycling?
Few.
Few.
https://twitter.com/EthicalSkeptic/status/1970234575260709187
ROOM silent as I spoke. It's a true story........
It was Decemeber 2010 and a my team of anesthesia people asked me to sit in on a continuing education class in the surgery department on one my surgery days.
I realized in 1 minute this was a BigHarma circle jerk.
The primary brand name for intravenous (IV) acetaminophen in the United States is Ofirmev. The medication is used to treat mild to moderate pain, fever, and moderate to severe pain in combination with opioid analgesics. They wanted my opinion on if I was OK using this as part of the anesthesia alogrithm for post op pain management in brain and spine cases and because I did most of the neurosurgery volume in the hospital in 2010 they wanted me to make the call. They knew I knew a lot of pain, POMc, and tylenol, because I had banned the use of this drug from all my patients in 2002.
I listened to the drug reps and reviewed what they brought me. First question I asked the reps what did they think about the 1998 actions of the UK on this drug.
Dead silence in the conference room filled with free BigHarma merch and food. 5 reps to cover the entire anestheisa and surgery dept. At the time, the anesthesia and general surgery depts were filled with employed MDs who worked for the hospital system. No one in the neurosurgery or orthopod dept were employed. At this time I noted the COO of the hospital was sitting in the back of the room.
I told the room filled with MDs and CRNAs that I banned the use of this drug after the 1998 UK black box warning. The published stories of the UK action was that typical UK pack size became restricted. In 1998, the UK limited the pack sizes of paracetamol available over-the-counter to reduce cases of intentional self-poisoning. If you could self poison yourself with an OTC medicine I said I need to find out why that happens.
ROOM silent as I spoke because they knew about how I fact check everything.
It was Decemeber 2010 and a my team of anesthesia people asked me to sit in on a continuing education class in the surgery department on one my surgery days.
I realized in 1 minute this was a BigHarma circle jerk.
The primary brand name for intravenous (IV) acetaminophen in the United States is Ofirmev. The medication is used to treat mild to moderate pain, fever, and moderate to severe pain in combination with opioid analgesics. They wanted my opinion on if I was OK using this as part of the anesthesia alogrithm for post op pain management in brain and spine cases and because I did most of the neurosurgery volume in the hospital in 2010 they wanted me to make the call. They knew I knew a lot of pain, POMc, and tylenol, because I had banned the use of this drug from all my patients in 2002.
I listened to the drug reps and reviewed what they brought me. First question I asked the reps what did they think about the 1998 actions of the UK on this drug.
Dead silence in the conference room filled with free BigHarma merch and food. 5 reps to cover the entire anestheisa and surgery dept. At the time, the anesthesia and general surgery depts were filled with employed MDs who worked for the hospital system. No one in the neurosurgery or orthopod dept were employed. At this time I noted the COO of the hospital was sitting in the back of the room.
I told the room filled with MDs and CRNAs that I banned the use of this drug after the 1998 UK black box warning. The published stories of the UK action was that typical UK pack size became restricted. In 1998, the UK limited the pack sizes of paracetamol available over-the-counter to reduce cases of intentional self-poisoning. If you could self poison yourself with an OTC medicine I said I need to find out why that happens.
ROOM silent as I spoke because they knew about how I fact check everything.
3. I then asked my assistant to go into my orders set. Back then there was no electronic records. I had a manilla envelop with a printed protocol that was to be placed on every case I did in this hospital. Here is below. Note the fourth line of this document.
I asked the reps what was the effect of IV route of administration on endogenous glutathione levels.
Crickets.
The reps with skirts and stocking and revlon make up all said that no preclinical studies were done on glutathione levels and the drug.
That raised my eye brows in a big way.
WHY?
I asked the reps what was the effect of IV route of administration on endogenous glutathione levels.
Crickets.
The reps with skirts and stocking and revlon make up all said that no preclinical studies were done on glutathione levels and the drug.
That raised my eye brows in a big way.
WHY?
4. I told the three pretty little girls working for Cadence Pharma that any PDR would show that acetaminophen clearance is critically dependent on glutathione (GSH) for detoxification, especially during an overdose.
At thos point my anesthesia team opened the PDR in the anesthesia dept library because that is the conferemnce room where the administration of the hospital set it up.
My head gaspasser announded to the room at therapeutic doses, a small, toxic byproduct is neutralized by glutathione.
He went on to point out, that large dose can deplete the liver's glutathione stores, leading to severe and potentially fatal liver damage.
I asked the room do you think the oral route and the iV route of administration are the same?
At thos point my anesthesia team opened the PDR in the anesthesia dept library because that is the conferemnce room where the administration of the hospital set it up.
My head gaspasser announded to the room at therapeutic doses, a small, toxic byproduct is neutralized by glutathione.
He went on to point out, that large dose can deplete the liver's glutathione stores, leading to severe and potentially fatal liver damage.
I asked the room do you think the oral route and the iV route of administration are the same?
5. I told the entire room that the PDR was written exclusively about the oral route.
I then readdressed the reps trying to give us the marketing ploy.........
What is the data on the IV route?
Crickets.
BigHarma was not required to run studies because tylenol was already approved for use.
Right about then the MDs in the room became quite uncomfortable.
I asked the room how many people were given this drug this AM before I came into the room by the staff?
The answer was 11.
I asked who were the surgeons and could I speak to a few of them. I did and I asked them to get consent to get their patient blood drawm to test it for glutathione and its metabiolities and for me to have an extratube to test it optically. I got three yes answer.
I then readdressed the reps trying to give us the marketing ploy.........
What is the data on the IV route?
Crickets.
BigHarma was not required to run studies because tylenol was already approved for use.
Right about then the MDs in the room became quite uncomfortable.
I asked the room how many people were given this drug this AM before I came into the room by the staff?
The answer was 11.
I asked who were the surgeons and could I speak to a few of them. I did and I asked them to get consent to get their patient blood drawm to test it for glutathione and its metabiolities and for me to have an extratube to test it optically. I got three yes answer.
6. All three patients had critical losses of glutathione and the metabolites pathways lit up like a firework display. A week later the optical testing came back and it was more devastating.
I then asked the Anesthesia Dept who booked the meeting? I was told the COO did.
I asked the reps what was the cost of the drug to the hospital and what was the codes used. They would not answer because the COO was in the room.
So then I asked the question differently. I know the charge for two tylenol is 13 dollars a tablet in this facility. Is the use of this medication more or less the cost of two oral tylenol. The pharmacy nurse chimed in and told me the cost was exponentially more than the oral route.
At this time the COO stormed out of the room.
I made my point to everyone.
I then asked the Anesthesia Dept who booked the meeting? I was told the COO did.
I asked the reps what was the cost of the drug to the hospital and what was the codes used. They would not answer because the COO was in the room.
So then I asked the question differently. I know the charge for two tylenol is 13 dollars a tablet in this facility. Is the use of this medication more or less the cost of two oral tylenol. The pharmacy nurse chimed in and told me the cost was exponentially more than the oral route.
At this time the COO stormed out of the room.
I made my point to everyone.
7. As I finished my lecture to these clowns......I gave them a history lesson. Optical scanning became widely available to Big Pharma for inventory, tracking, and serialization purposes in the late 1970s, but regulatory mandates didn't compel its widespread use until the 2010s. I told the room that these reps bosses had the ability to optical scan molecules just as an NMR machine does in a chemistry lab and none of them were telling you the truth because MARKETING IS LEGALIZED LYING.
I found out later that week the hospital would have pulled in 1500 bucks for one dose of this poison, FYI
Today this drug is used by 99.9% of anesthesia depts.
JUST NOT MINE.
I found out later that week the hospital would have pulled in 1500 bucks for one dose of this poison, FYI
Today this drug is used by 99.9% of anesthesia depts.
JUST NOT MINE.
8. Does tylenol cause anemia since it affect gluthathione recycling in humans? Yep. A small portion is converted into a toxic byproduct called NAPQI. Normally, this is neutralized by glutathione and safely excreted.
Overdose and toxicity: In an overdose, the normal metabolic pathways become saturated, leading to a large amount of toxic NAPQI being produced. This rapidly depletes the body's glutathione stores.
Oxidative stress: Without enough glutathione to neutralize it, the excess NAPQI causes oxidative stress, which damages cells, including red blood cells. --->
patreon.com/posts/decentra…
Overdose and toxicity: In an overdose, the normal metabolic pathways become saturated, leading to a large amount of toxic NAPQI being produced. This rapidly depletes the body's glutathione stores.
Oxidative stress: Without enough glutathione to neutralize it, the excess NAPQI causes oxidative stress, which damages cells, including red blood cells. --->
patreon.com/posts/decentra…
9. What centralized MDs never tell people about tylenol. The drug causes anemia. This means it alters the UPE profile of RBCs.
Implications?
Reduced heme availability in the RBCs of the eye/CNS, gut, and skin sets off a systemic cascade, signaling bone marrow dysfunction and initiating ACD.
These all directly affect UPE transformations. This is a key communication breakdown in quantum biology.
Blood is 93% water, and generates UPE via ROS from hemoglobin/heme interactions (e.g., 380-450 nm from Fenton reactions).
Now add in the neurosurgery risks: With 20% of cardiac output perfusing the brain, this UPE flux is UBER significant to millions being sold a poison, supporting mitoception and neural energy changes = brown out mechanism in many organs.
Implications?
Reduced heme availability in the RBCs of the eye/CNS, gut, and skin sets off a systemic cascade, signaling bone marrow dysfunction and initiating ACD.
These all directly affect UPE transformations. This is a key communication breakdown in quantum biology.
Blood is 93% water, and generates UPE via ROS from hemoglobin/heme interactions (e.g., 380-450 nm from Fenton reactions).
Now add in the neurosurgery risks: With 20% of cardiac output perfusing the brain, this UPE flux is UBER significant to millions being sold a poison, supporting mitoception and neural energy changes = brown out mechanism in many organs.
10. There is a reason Susie Wiles wants me no where near MAHA and RFK Jr.
I am a great white shark for the truth.
No one can handle the truth.
At every level they are doing harm and most of you keep allowing them to do it.
I am a great white shark for the truth.
No one can handle the truth.
At every level they are doing harm and most of you keep allowing them to do it.
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