Now common things (common, not everything) that can cause one's melatonin levels to drop include:
1. Exposure to artificial blue light (especially after sunset) from sources such as LED lights, your laptop, PC, TV etc 2. Shift work 3. Sodium fluoride 4. Chronic stress 5. Medications such as NSAIDs, beta-blockers, some SSRIs 6. Stimulants (caffeine, nicotine etc) 7. Deficiencies in magnesium, zinc, B6, B12, B9, potassium, calcium that directly or indirectly (through methylation or pineal health for example) affect the production of melatonin (magnesium and B6 for example help with the conversion of tryptophan to melatonin)
So for starters, avoid these (get a pair of blue light blockers, get enough of the mentioned nutrients, take a break from stimulants etc).
Number 2: Flicker maxing through screens.
Simply put, spend less time in front of screens and go outside.
This will also help you with your vitamin D levels since higher circulating vitamin D levels are associated with decreased migraine risk.
Number 3: Magnesium deficiency.
During a migraine attack, even up to 50% of people have lowered levels of ionized magnesium so do not underestimate the impact that these basic things can have.
Number 4: Additives found in processed foods such as MSG.
ncbi.nlm.nih.gov/pubmed/7635722
Now of course, the NMDA receptors that are found in the meningeal afferents of the trigeminal nerve are known to be involved in migraines so others things to keep in mind would include:
-Further avoiding the regular consumption of foods that have free-form glutamate such as :
● Monopotassium glutamate
● Wheat gluten
● Maltodextrin
● Modified food starch
● Corn starch and corn syrup
● Barley malt
● Calcium caseinate
● Rice syrup and brown rice syrup
● Xanthan gum
● Pectin
● Carrageenan
● Bouillon
● Citric acid
-In the short run in case you’ve been struggling with an excess, it might be a good idea to also avoid naturally high-glutamate foods such as fermented foods for instance.
-Avoiding the daily usage of stimulants.
-Getting enough magnesium and vitamin B6 (a lack of these two nutrients will lead to a glutamate excess through harming its conversion. The enzyme glutamate decarboxylase that was mentioned prior for example, used B6 as cofactor)
-Consuming enough bioavailable protein. Consuming 1.8 pounds of bioavailable protein per pound of bodyweight which is shown to reduce serum glutamate.
Number 5: nnEMFs.
Now before getting weird, simply start by throwing your airpods away (use wired headphones instead) and don't sleep next to the wifi router.
-Magnesium
-Taurine
-Potassium
-Vitamin K2
-Sunlight for vitamin D
-Thiamine
can help you with intracellular calcium as well.
Number 6: Elevated homocysteine levels/deficiencies in B2, B6, B9, B12, MTHFR SNPs .
Number 7: Insulin resistance.
*Anecdotally, plenty of people who get on GLP-1s note that their migraines go away.
Number 8: Monitor your O3:06 ratio and get enough vitamin E.
O3s compete with O6s fatty acids for the desaturase and elongase enzymes (delta-6-desaturase, delta-5-desaturase) so getting not only plenty of linoleic acid but also very few O3s, allows more linoleic acid to be converted into AA.
If the issue is menstrual migraines, consider supplementing with whole food vitamin E as well.
That's all.
P.S: When it comes to serotonin, the main problem is that we do not know if serotonin causes migraines or if migraines cause changes to the serotonin receptors.
It seems that during migraine attacks, ones serotonin levels are low-ish, BUT, at the beginning of an attack, they seem to rise very fast.
Why is this an issue? Because once the sudden rise leads to fast vasoconstriction and once it's starting to break down a fast vasodilation happens (if you have ever quit nicotine, just imagine 10X the headaches during withdrawals).
L reuteri is missing in a lot of people (especially those who weren't breastfed (reason why you can literally give it to these children and they will cry less)).
Yet, the most popular strains can:
-Reverse some markers of ageing
-Inhibit inflammatory processes in the gut
-Make bones stronger
-Be quite helpful for oral candidiasis (in most species as well)
-Improve insulin resistance
-Increase testosterone
-Increase oxytocin
-Grow your balls
-Increase vitamin D levels, reduce LDL-C by 11.64% and apoB-100 by 8.41% relative to placebo
Downsides:
-Not ideal for people with MCAS
-Not ideal with people with hydrogen dominant SIBO
Here's how you can cover the vast majority of your micronutrient needs through delicious foods.
Thread 🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*
It's George.
First and foremost, let's see why multivitamins are a scam and why you should take your hard-earned money and purchase some real food instead.
For starters, realize that the claim for that multivitamins extend lifespan has been debunked for a long time and that you have higher chances of living longer if you are religious (not a joke).
Then, another big problem regarding this is that supplements overall, even though certain ones can be VERY helpful at times, lack transport proteins and all nutrients work synergistically.
For example:
-Selenium, sulfur, iodine, CoQ10, manganese, vitamin E, B2, iron.
-Thiamine, manganese and magnesium.
-B6 and B2.
-Zinc and copper.
-Retinol, DHA, E and B2.
-Vitamin K and retinol.
-Potassium and sodium.
-Choline and B9.
-B5 and K.
-Iron, B2, B12, B9 copper, D, retinol and C.
-Vitamin D, magnesium and retinol.
Etc
So when we eat a piece meat for example, we are not consuming just one or a few nutrients without transport proteins compared to an iron supplement for example.
On the flipside, when we consume a multivitamin that has every single nutrient, this might sound good but it’s really not.
“This pill provides me with every nutrient i need (on paper)”.
Sounds good but it’s not how our body works.
-Calcium, zinc and iron for example compete for absorption in the small intestine through DMT1.
-Then vitamin E in large amounts can interfere with some of the effects that vitamin K has such as its role in blood clotting, high doses of zinc can reduce folate absorption, high doses of vitamin C can reduce the availability of B12 to a great extent and excessive vitamin A can interfere with vitamin D’s ability to regulate calcium.
Jeremy Renner was run over by a 14,300-pound snowplough while trying to prevent it from hitting his nephew.
He was airlifted to the hospital, had more than 30 broken bones and yet somehow he has achieved a remarkable recovery.
This was partly possible thanks to peptides.
So here's the Avengers' peptide stack.
Thread🧵
It’s George.
Peptides can legitimately help with almost every goal people chase today:
-Extreme fat loss
-Improved memory recall, mood, mental clarity, focus etc
-Healing gut issues
-Healing common gym injuries
-Restoring libido and sexual function
-Rebuilding a broken immune system
-Slowing biological aging
And many more…
BUT, peptides are also one of the deepest, most confusing rabbit holes in modern health and performance.
So take 10 minutes to read this before you buy a single vial.
First, the non-negotiable disclaimers: 1. Nothing here is medical advice. 2. Target the root cause of your issues as well.
Peptides are amplifiers, not magic wands. 3. Scams are everywhere in 2025. 4. Talk to an actual doctor. 5. Stacking 5–10 peptides with no bloodwork is playing Russian roulette with expensive water.
Different peptides need different environments (PHs etc), have different half-lives and act on different receptors/sites.
General idiot’s rules of thumb:
-You don’t need more than 3 peptides at a time, most likely unless you are almost dying.
-If the liquid in your syringe turns cloudy once you mix your peptides, they are ruined.
-Cerebrolysin and GHK-CU should not be paired with anything.
-Do not stack BPC-157 or TB-500 with anything related to GH.
-Space injections at least 30 minutes apart.
Jeremy Renner himself has stated that he takes 3 months off peptides and does 2-3 months on.
Here's what i eat in a day to support my:
-Hormones
-Mood
-Gut
-Cardiovascular health
-Immune system
-Libido
-Skin health
and my health overall.
Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*
It's George.
The purpose of this thread is for you to get ideas and become more interested when it comes to the impact that food has on our bodies.
This is not "the perfect" or "ideal" meal plan.
Coming up with a perfect diet plan is like coming up with a perfect workout plan.
Past a certain point, it will be heavily affected by your goals, training history, current injuries, old injuries, what the person has access to and so on.
The same thing is true for coming up with a “perfect” diet plan.
We need to know the goals of the person, issues that he might be struggling with, how much money he can spend and so on in order to make up a “perfect” diet plan.
So: just take ideas and data from this instead of treating it dogmatically.
Meal 1 (breakfast).
Yes, i eat breakfast since meal timing is NOT irrelevant for our health when every single thing in the human body follows a circadian pattern.
This meal consists of:
-Pasture raised eggs + mushrooms cooked in coconut oil
-Raw goat's kefir with some raisins, one Brazil nut, raw honey (this one has some propolis), kiwis, Ceylon cinnamon, glycine (3 grams), vanilla extract, taurine (1 gram), colostrum, bee pollen, berries and a bit of pomegranate.
-Nettle root gelatine + pomegranate
Supplements: 950mg of magnesium acetyl taurate, 400mg of cistance, 250IUs of full spectrum vitamin E
Here are some supplements that don't and can actually help you in a variety of areas ranging from your brain and gut health all the way to your hormones and skin health.
Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*
Note: This is about supplements indeed but if you do not get sunlight, exercise, eat whole foods, try to avoid vices such as excessive alcohol consumption and so on, then supplements will not save you.
Plenty of foods have more benefits that not only compared to the supplements at a low/medium price point but a very high as well. If a supplement, had the history and benefits of kefir for example, it would sell a lot. It’s just that you can only make so much profit from foods. I can’t sell you for example a $30 bottle of kefir yet i can very easily sell someone a $30 bottle of probiotics.
The right supplements CAN be useful and maybe even life saving. I am not dismissing them. At all. This is why we will talk about them.
This is just about having the right priorities.
Also, every single of these supplements that are mentioned will backfire for some people.
It's mathematically impossible not to.
If only 3.000 people read this and out of them 300 choose to use one, it's impossible for one of them to not react badly to it.
Does this fact make the supplement bad? No.
It makes it bad within a certain context.
So, read the studies that are linked.
Now let's talk about the supplements (not presented by order of importance).
Number 1: Magnesium.
Magnesium is involved in over 3700 enzymatic reactions in the body.
So without enough magnesium, nothing really works. But supplement wise, which form should you pick?
Here's a basic breakdown
Form 1: Magnesium citrate
This is a quite bioavailable form (not as much as glycinate or malate though in many cases) that combines magnesium with citric acid but because of this (most commercial citric acid comes from Aspergillus species), you should only use it to resolve constipation and if you have MCAS or histamine intolerance you should not use it.
Form 2: Magnesium oxide.
Throw this in the trash.
This is just a cheap form that results in the creation of pro-oxidant compounds (obviously) with a 4% bioavailability (to put this into perspective, glycinate can reach up to 40% in some cases).
Form 3: Magnesium glycinate.
This is a form where magnesium is bound to glycine and the form that most people should start with since it’s pretty bioavailable, cheap and it’s great for supporting sleep and stress reduction.
Form 4: Magnesium malate.
This is a form where magnesium is paired with malic acid (a compound that’s found in apples).
It’s perfect for people who either battle aluminum toxicity or just focus on overall detoxing.
All forms of magnesium can help by lowering aluminum retention in bones and tissues overall but malic acid can also bind certain heavy metals such as aluminum.
The effects are mild and you can not rely just on this for aluminum toxicity, but it’s something good to know in my opinion. Compared to other oral forms, it seems to be better for muscle recovery as well and support the krebs cycle more.
Form 5: Magnesium threonate
This form, has gained a lot of popularity for the overall benefits it can have on the brain and that’s because it crosses the blood-brain barrier. It’s a form where magnesium is bound to threonic acid (a metabolite of vitamin C).
Form 6: Magnesium acetyl taurate
If you have high blood pressure, anxiety and want to focus on your overall CVD health, this form is for you.
Form 7: Magnesium chloride
This form where magnesium is bound to chloride, is typically used for muscle recovery but it’s also great for people who have serious digestive issues and can’t absorb a lot of things.
Disclaimer: If you are extremely deficient in magnesium and decide to use MgCl, it will sting, a lot.
From 8: Magnesium sulfate (Epsom salts)
This from where magnesium is paired with sulfate is also great for muscle recovery but not ideal for increasing the levels within our bodies.
Note 1: If you have profound gut issues and for whatever reason you also react badly to topical forms of magnesium. Magnesium l aspartate hydrochloride is your best bet since it does not really alter gastric pH or binds hydrochloric acid.
Note 2: When it come to bicarb, it could reduce calcium buildup in soft tissues a bit and help with constipation. But it's quite expensive and if you choose to make it yourself, make sure that it stays cold, not overconsuming in order to not dilute my stomach acid etc.
While almost everyone is looking at expensive biohacks, proper sauna use is still one of the best and proven ways to:
-Reduce fatigue in patients with chronic fatigue syndrome
-Rapidly alleviate depression
-Detox from industrial toxins
-Support the immune system
-Enhance physical performance
-Promote myelination
-Improve cardiovascular health
-Protect against neurodegenerative diseases
-Alleviate chronic pain
-Resolve insomnia
and more.
Here’s the ultimate guide to sauna therapy.
Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*
For the few of you who might be unaware, sauna therapy involves controlled exposure to heat, typically in a traditional (hot rock/steam) sauna (160-200°F, 70-100°C) or an infrared sauna (120-140°F, 49-60°C), inducing hyperthermia and sweating.
This triggers a cascade of physiological responses, including activation of the HPA axis, sympathetic nervous system and heat shock protein (HSP) pathways.
These responses drive adaptations in neuroendocrine, cardiovascular, immune and integumentary systems, contributing to the following benefits.
But besides these, saunas have been a cornerstone of wellness practices for centuries, from the sweat lodges of indigenous cultures to the Finnish saunas embedded in modern spa culture.
So let's see some benefits (some of which we've known for 30+ years).
Number 1: Mood enhancement and depression reduction.
In one study, a single infrared sauna session (at 135-140°F for 30 min) reduced depression symptoms by ~50% in patients with major depressive disorder.
Not only that, but the effects persisted for six weeks.
This outperformed SSRIs (3-4x effect size) and exercise (2x effect size).
Another study on mildly depressed patients with fatigue and appetite loss reported significant improvements in appetite and mental complaints after infrared sauna therapy.