I eliminated 85% of microplastics from my ejaculate.
Nov 2024: 165 particles/mL
July 2025: 20 particles/mL
Nearly identical drop in my blood same time period:
Oct 2024: 70 particles/mL
May 2025: 10 particles/mL
Important as a meta-analysis of 36 studies reveals that microplastics induce oxidative stress in the male reproductive system, leading to testicular inflammation, cell death, and reduced testosterone levels, sperm production, and motility.
Two studies last year showed that microplastics were detected in every human testicular and semen samples tested.
The therapy we think most responsible for this reduction is sauna as it also eliminated most environmental toxins in my body, including those linked to various plastics (200 F, 20 min daily w/ ice on the boys). I also avoid the big no-no’s like microwaving in plastic, plastic cutting board, and having a reverse osmosis water system.
To our knowledge, this is the first report of any correlation (esp in the same person over two timepoints) between blood and semen microplastic levels, demonstrating successful microplastic detoxification in the semen following that in the blood.
1/ My results offer a new sense of hope for the detoxification of microplastics from the testis and semen, especially after the concerns raised by a study last year.
To our knowledge, this is the first report of any correlation (especially over two timepoints) between blood and semen microplastic levels, demonstrating successful microplastic detoxification in the semen following that in the blood.
This is encouraging news, as recent reports of microplastic accumulation in the testis have specifically raised concerns about microplastics accumulating in reproductive tissues, with the reversibility of such accumulation being uncertain.
Earlier last year, a study made headlines by reporting high levels of microplastic particles in the testicles of deceased humans and dogs. Microplastics were positively detected in every tested sample at average concentrations of 328.44 µg/g and 122.63 µg/g, corresponding to approximately 5.9 x 10¹¹ and 2.2 x 10¹¹ micro- and nanoplastic particles per gram of testicular tissue (1µg ≈ 1.8 x 10⁹ particles).
It is important to note that this is a rough estimate, as this number converts all detected microplastic molecules to particles, while some plastic material might also exist in dissolved monomeric or oligomeric forms. These figures roughly correspond to 2.2 x 10¹¹ and 5.9 x 10¹¹ particles/g, depending on the size and type of the microplastic particles.
An earlier study reported a lower number of microplastic particles per gram of testicular tissue and 0.23 particles/mL of semen. However, this study likely underestimated the numbers due to a high cut-off size.
2/ Similar correlations have been observed for plastic leachables, but never for microplastics, and never longitudinally over time with effective mitigation interventions.
Earlier studies showed correlations between serum, blood, and urine for some plastic leachables, including BPA and some phthalate metabolites. However, these were single-time point studies with no longitudinal follow-up or mitigation interventions.
BPA levels in semen correlated with blood levels and lower semen motility. Microplastics in semen can also leach BPA and other chemicals, in addition to their direct mechanical disruption of testicular tissue, triggering a range of oxidative, inflammatory reactions, and hormonal and endocrine disruptions.
3/ Microplastics in the testis and semen can disrupt sperm motility, hormones and fertility markers, the good news this seems all reversible based on my results.
A 2024 study from China, involving 113 participants, corroborated these findings, detecting microplastics in all tested semen and urine samples. This study further elaborated on the risks associated with specific microplastic particle exposure, revealing that PTFE exposure correlated with relative reductions of 14% in sperm total counts, 9% in concentration, and 15% in motility.
Additional analysis indicated that each extra type of microplastic particle detected heightened the risk of fertility disruption. PTFE, in particular, was 3.5 times more likely to impair semen quality compared to other microplastic types.
As PTFE is commonly used in Teflon non-stick cookware, this provides another compelling reason to completely avoid such products.
A meta-analysis of 36 studies reveals that microplastics induce oxidative stress in the male reproductive system, leading to testicular inflammation, cell death, and reduced testosterone levels, sperm production, and motility. For example, mice exposed to polystyrene microplastics in drinking water exhibited lower blood testosterone, decreased sperm viability, and increased sperm abnormalities. Microplastics were found to infiltrate and disrupt the function of Leydig cells, which are responsible for testosterone production.
The presence of environmental toxins in semen has long been recognized as an early indicator of exposure. For instance, studies have shown that new exposure to heavy metals like cadmium, copper, and zinc leads to earlier and higher concentrations of these metals in semen, with a corresponding decline in semen quality and viability. My findings suggest that this principle extends to microplastic particles as well: microplastics appear in semen earlier and in potentially higher concentrations. The good news is that these effects seem to be fully reversible once blood levels are corrected.
* a reverse osmosis water system is good to filter out microplastics. Sorry for botching that sentence.
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My 4+ hour daily routine resets my blood vessels to perform like they did in my teenage years. 🧵
0/ Here is the level of vascular function reset and rejuvenation enabled by my morning routine, every single day
+ Central blood pressure: 86 mmHg (lower than 99% of males < 20)
+ Peripheral blood pressure: Systolic 94/ Diastolic 56 (lower than 99% of males < 20)
+ Vascular elasticity and compliance (softness):
a) Augmentation pressure: -1 mmHg (lower than 50% of males < 20)
b) Augmentation index: -4% (lower than 60% of males < 20)
1/ I previously shared that my sauna protocol has restored my vascular function and blood flow to levels typical of a healthy 20–25 year old. This effect has been observed consistently, whether the readings are taken upon waking or later in the day.
However, my morning routine, which combines exercise sauna, red/NIR light therapy, and HBOT or IHHT, takes this to the next level.
Daily, it guides my arteries and vascular system into a state of relaxation, akin to a soothing massage for your blood vessels.
This is big. OpenAI and Retro used a custom model to make cellular reprogramming into stem cells ~50× better, faster, and safer. Similar Wright brothers’ glider to a jet engine overnight.
We may be the first generation who won't die.
Let's take a look at what they did. 🧵
0/ AI Redesigns the Engines of Cellular Reprogramming
OpenAI and Retro Biosciences reported a landmark achievement: using a domain-specialized protein design model, GPT-4b micro, they created engineered reprogramming factors that deliver over 50× higher efficiency in generating induced pluripotent stem cells (iPSCs), with broad validation across donors and cell types. These AI-designed proteins not only accelerate reprogramming but also enhance DNA repair, overcoming DNA damage as one cellular hallmark of aging hinting at relevance for aging biology.
1/ 0/ From Yamanaka’s Discovery to Today
In 2006, Shinya Yamanaka identified four transcription factors; Oct4, Sox2, Klf4, and c-Myc (OSKM), capable of resetting differentiated adult cells into a pluripotent, embryonic-like state. This breakthrough opened two revolutionary doors in biology:
1) Full reprogramming: completely erasing cell memory, identity, to generate pluripotent stem cells (iPSCs) for regenerative medicine, tissue engineering, and disease modeling.
2) Partial reprogramming: transient expression to roll back cellular age without erasing cell identity.
This remarkable discovery won Yamaka the Nobel Prize for Physiology or Medicine in 2012.
Yet, in practice, OSKM are astonishingly inefficient (<0.1% conversion, requiring +3 wees of culture) and carry oncogenic risks, particularly from c-Myc. These limitations have long restricted their therapeutic potential. These limitations have limited the progress in regenerative medicine due to the difficulty of scaling the safe and reliable production induced pluripotent stem cells.
I sacrificed my fertility for this message:
ice your balls in the sauna
After icing improved my fertility markers,
I removed the ice to validate
The boys suffered. More than we initially thought.
Here’s my latest results explained. 🧵
0/ Results from sauna experiment
27 daily sauna sessions with ice on balls:
+ total motile count ↑ 57%
+ motility ↑ 16%,
+ total count ↑ 43%
2 weeks without icing (15 sauna sessions with full heat on balls)
my boys’ motility decreased, counts unaffected
total motile count ↓ 54%
motility ↓ 57%
total count ↑ 6%
direct hit to motility and total motile count due to mature sperms in storage (sperm is stored for a couple weeks between full maturation and ejaculation in the Epidimysis).
1/ One week post re-icing: misleading partial recovery (values compared to pre-sauna baseline)
total motile count ↓2%
motility ↓ 34%
total count ↑ 56%
4 weeks post re-icing: 2nd wave of heat effects: large drop in count, motility.
total motile count ↓ 56%
motility ↓ 50%
total count ↓ 9%
Latent hit to counts and motility:
heat damages early spermatogenesis (meiosis) and later sperm maturation (morphological changes, tail formation, and cytoplasmic loss) leading to a reduction in sperm count and motility.
The effect is latent because the "faulty batches" from heat exposure with fewer total and motile sperm are only apparent in test after being stored for a couple weeks in the epididymis.
It takes 23 mins on avg to regain focus after being distracted by your phone. Only allow text notifications from people who contact you in an emergency.
If you do need notifications, be strategic about which ones you allow:
2. Resist the urge to check Instagram and TikTok
Apps like One Sec or Opal let you add loading screens before accessing addictive apps.
They can force you to look at yourself in the camera for a few seconds, or make you spin your phone around 4 times before granting access.
If that doesn’t work:
The app Brick comes with a physical “brick” to lock or unlock groups of apps on your phone.
+ Put the brick on your fridge
+ Tap your phone against it to block all non-work apps
+ Go to the kitchen to unlock if you need to check something or spend 15 mins on social media
You can also give someone else the Brick to keep you accountable.
I've worked very hard to maintain my hair....I've tried a lot of things over the years to stop hair loss and grow strong healthy hair. I’ve injected PRP and dutasteride into my scalp way too many times. That hurts like hell and I don’t think the PRP helped at all.
I tried a lot of other things too and few if any actually work. So my team and I built our own solution.
It’s the most advanced formulation I’ve seen.
It’s now available if you want to give it a try. Like all things with hair, you need to be consistent for at least 4 months.
Here’s what’s in it and why I’m excited about it.
0/ What the product has:
+ 8 biomimetic peptides, more than any other product. And in the highest concentrations.
+ We put every peptide in its own patented delivery system so it reaches the exact receptor it’s designed to target for maximum impact.
+ We integrated patented nanofluorosome technology that is activated by the Blueprint Laser Cap (avail in Sept).
The serum is water-based, lightweight and dries completely residue free.
Layers of interventions and actives stacked upon each other.