Thread by @1goodtern

How's that lymph system doing.

Blastic NK-cell lymphoma, England.

Blastic NK-cell lymphoma means something has gone *really wrong* in immune regulation.
It’s a malignancy of the cells that are *supposed to destroy infected cells*.

NK cells - "natural killer” cells - are the immune system's first-strike unit.
They're the ones that find and kill virus-infected cells before antibodies even show up.

If you start seeing more NK-cell cancers, something’s driving chronic activation and mutation inside that system.

Something up here.

Now, think about Covid infection:
Every infection triggers a massive NK-cell surge.
Those cells get overstimulated, exhausted, and sometimes permanently altered.

Post-COVID studies show lingering activation markers, basically, NK cells stuck in attack mode for months.

That means they keep dividing...
Keep generating oxidative stress...
Keep collecting DNA damage in a high-inflammation environment...

And all that while the repair pathways (like p53) are being suppressed (by cytokines like IL-6 and TNF-alpha).

At the same time, the immune brakes are off.
T cells are depleted and exhausted.
Interferon signalling is blunted.

So when an abnormal clone of NK cells appears, the immune system doesn't clear it. *It lets it grow*.

Add to that the reactivation of latent viruses (EBV, CMV, HHV-6) all known to cause NK/T-cell malignancies...
COVID reawakens them, repeatedly.
Each reactivation wave means another round of inflammation and oxidative stress and immune dysregulation.

The problems aren't just in adults... there's stuff going on in kids too.

So you end up with this:
A system of immune cells pushed to divide too often,
mutating in an inflamed environment,
with the tumour-suppressor side of immunity switched off.
And from that, you get what we’re seeing here. A surge in blastic NK-cell lymphoma.

I wonder what else is going on in that lymph system...

Oh boy.
😮

Oh boy.

Oh boy oh boy

Erm.
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And then strange things going on with other aspects of the immune system...

And this running away...

And then damage to all that lets this kind of damage loose...

And that this...

Hmm.
Those gut infections are really exploiting something these last four years, aren't they...

Oh my word.

👀

This is all just nuts.

This damage is in adults, kids, infants, everywhere.

It's in these kind of diseases where the end result is scarring of internal organs after immune hyperactivation:

This is in KIDS AGED 0 to 9.

You might expect this to pop up as a result of immune dysregulation in the gut...

Oh boy.

What the what.

What does inflammation in the brain cause...

More tomorrow... this list is long.

Maybe a few more...

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This is in *kids*
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This is in *young adults* 👀

flip.

Nothing to see here, just a doubling of TUBERCULOSIS OF BONE.

Oh dear.

Hmm.
I didn't expect so many people to read this thread, or I would have included a bit like this, explaining that not every condition is rising like that...

https://x.com/1goodtern/status/1979261020150333659?t=dnq8OvfKaYZtynun7TAQDQ&s=19

@PetersCynthia There's 9,000 charts in the database, it's hard to even view them all, let alone post them!