Everyone’s chasing weight-loss injections…but few know the real secret: they’re based on incretins, your body’s own satiety hormones.
Here’s how to activate them naturally to burn fat and reverse metabolic dysfunction:
Here’s how to activate them naturally to burn fat and reverse metabolic dysfunction:
1. The billion-dollar secret.
Drugs like Ozempic and Wegovy work by mimicking a natural gut hormone called GLP-1, part of a group called incretins.
Drugs like Ozempic and Wegovy work by mimicking a natural gut hormone called GLP-1, part of a group called incretins.
They slow digestion, balance blood sugar, reduce appetite, and improve insulin sensitivity.
But your body can make GLP-1 naturally if you know how to activate it.
But your body can make GLP-1 naturally if you know how to activate it.
2. What incretins do:
• Reduce liver glucose output
• Improve metabolic flexibility
• Signal fullness to your brain
• Stimulate insulin after meals
• Calm inflammation in blood vessels
When this pathway weakens (through poor diet, stress, or sleep loss), hunger and cravings dominate.
• Reduce liver glucose output
• Improve metabolic flexibility
• Signal fullness to your brain
• Stimulate insulin after meals
• Calm inflammation in blood vessels
When this pathway weakens (through poor diet, stress, or sleep loss), hunger and cravings dominate.
3. The GLP-1 crisis.
Modern ultra-processed diets and erratic eating blunt GLP-1 release.
That’s why people feel constantly hungry, even after big meals; their satiety hormones are silent.
Modern ultra-processed diets and erratic eating blunt GLP-1 release.
That’s why people feel constantly hungry, even after big meals; their satiety hormones are silent.
4. How to boost incretins naturally:
a. Eat real fiber.
Viscous fibers (oats, flaxseed, chia, psyllium, vegetables) feed gut microbes that stimulate GLP-1 release.
a. Eat real fiber.
Viscous fibers (oats, flaxseed, chia, psyllium, vegetables) feed gut microbes that stimulate GLP-1 release.
b. Add vinegar or lemon water before carb meals.
Acetic acid blunts glucose spikes and enhances GLP-1 response.
c. Prioritise protein at breakfast.
Protein triggers incretins early in the day, reducing appetite for hours.
Acetic acid blunts glucose spikes and enhances GLP-1 response.
c. Prioritise protein at breakfast.
Protein triggers incretins early in the day, reducing appetite for hours.
d. Take post-meal walks.
Light activity enhances incretin sensitivity and glucose clearance.
e. Sleep 7–8 hours.
Poor sleep suppresses GLP-1 and increases ghrelin (the hunger hormone).
Light activity enhances incretin sensitivity and glucose clearance.
e. Sleep 7–8 hours.
Poor sleep suppresses GLP-1 and increases ghrelin (the hunger hormone).
f. Cold exposure & Zone-2 training.
Both improve mitochondrial function and boost GLP-1 sensitivity.
Both improve mitochondrial function and boost GLP-1 sensitivity.
5. Food compounds that support GLP-1:
• Capsaicin (chili)
• Citrus bioflavonoids
• Green tea catechins
• Polyphenols (berries)
• Sulforaphane (broccoli sprouts)
Nature built the same pharmacy — minus the side effects.
• Capsaicin (chili)
• Citrus bioflavonoids
• Green tea catechins
• Polyphenols (berries)
• Sulforaphane (broccoli sprouts)
Nature built the same pharmacy — minus the side effects.
6. The gut connection.
Your incretins are produced by L-cells in the gut lining. A healthy microbiome = stronger incretin release.
Artificial sweeteners, alcohol, and seed oils damage these cells while fermented foods, resistant starch, and probiotics heal them.
Your incretins are produced by L-cells in the gut lining. A healthy microbiome = stronger incretin release.
Artificial sweeteners, alcohol, and seed oils damage these cells while fermented foods, resistant starch, and probiotics heal them.
7. The pharmaceutical shortcut.
GLP-1 agonist injections suppress appetite artificially.
They work, but when you stop, hunger rebounds because your natural incretin system was never rebuilt.
That’s why long-term success depends on restoring your biology, not renting it.
GLP-1 agonist injections suppress appetite artificially.
They work, but when you stop, hunger rebounds because your natural incretin system was never rebuilt.
That’s why long-term success depends on restoring your biology, not renting it.
8. The natural reset:
By supporting your gut, balancing your circadian rhythm, and repairing mitochondria, you reactivate the same pathways billion-dollar drugs target — without dependency.
By supporting your gut, balancing your circadian rhythm, and repairing mitochondria, you reactivate the same pathways billion-dollar drugs target — without dependency.
That’s why I formulated the YouPeak Nighttime Metabolic Supplement. It’s designed to support gut-brain hormone balance, reduce inflammation and balance blood sugar.
Learn more: youpeak.co.uk
Learn more: youpeak.co.uk
Big Pharma copied your biology.
You don’t need a needle - you need to reactivate your natural satiety switch.
You don’t need a needle - you need to reactivate your natural satiety switch.
Follow @dr_sumit_sharma for science-backed ways to master metabolism, balance hunger hormones, and reverse disease naturally.
Rewteet to help someone: Fix their gut. Reclaim their hormones. Heal their metabolism.
Rewteet to help someone: Fix their gut. Reclaim their hormones. Heal their metabolism.
https://x.com/dr_sumit_sharma/status/1985685993077330118
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