Dr Sumit Sharma Profile picture
MD | Precision reversal of metabolic dysfunction for high-performers who've tried the basics. Uncovering what others miss. Longevity optimization. London-based.
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Feb 18 14 tweets 2 min read
In my clinic, the question is always the same: “What’s the fastest way to reverse insulin resistance?”

The answer isn’t dieting.

It’s leg strength.

Here’s the physiology most doctors never explain: Image Your skeletal muscle is the largest glucose sink you own.

When your legs are weak, they can’t clear glucose efficiently.

So your pancreas compensates.

It pumps out more insulin.
Feb 17 21 tweets 3 min read
Your pancreas ages before you do.

And by the time your fasting glucose rises, you’ve already been declining for years.

I’m Dr. Sumit Sharma. I help high-performers reverse metabolic dysfunction their labs “miss.”
Here’s what most doctors never explain: Image The Problem

Your doctor checks fasting glucose (70–100 = “normal”).

But fasting glucose is the last marker to change.
Feb 16 15 tweets 3 min read
I reversed insulin resistance in my clients by changing ONE variable: MEAL timing.

Not calorie counting. Not macros. Not supplements.
When they ate determined whether they stored fat... or burned it.

Here’s the metabolic mechanism most doctors miss: Image Your 10 pm dinner is metabolically different from your 6 pm dinner.

Same food.
Same calories.
Different hormonal outcome.

“Calories in = calories out” misses 40% of metabolic dysfunction.
Feb 9 14 tweets 3 min read
I’ve helped hundreds of patients reverse insulin resistance.

Here are 10 weight-loss myths keeping people metabolically broken.

(Some are still taught in clinics. Even your doctor believes #7.): Image Myth #1
“Just eat less and move more.” This ignores biology.

Your body isn’t a bank account - it’s a hormone system.

If insulin stays high, you’re in fat-storage mode even in a calorie deficit. Fix hormones first.
Feb 2 11 tweets 2 min read
You don’t fix insulin resistance with hacks.
You fix it with boring daily actions done consistently.

No keto. No starvation. No gym obsession.

Here are 5 daily habits that quietly repair insulin sensitivity: Image 1) Protein-first meals

Protein slows glucose absorption, lowers insulin spikes, and improves satiety.

30–40g per meal = better blood sugar control without cutting carbs.

Insulin resistance isn’t a carb problem. It’s a signalling problem.
Jan 30 16 tweets 3 min read
Fitness coaches say: optimise diet, macros, training.

Neuroscience says: chronic stress slows metabolism & trauma locks fat storage.

Both are right. Both are incomplete.

And that’s why ~80% of people stay stuck: Image The fitness-only model:

• Perfect calories
• Perfect macros
• Perfect training

Sounds logical.
Jan 29 21 tweets 3 min read
Chronic inflammation is ageing you 10 years ahead of schedule.

It’s not genetics, bad luck or getting old.
For most people, it's what you're eating every day.

I reverse inflammatory patterns in high-performers weekly. Here’s the food protocol that actually works: Image Your doctor says: "Your blood work is normal."

But you feel:
→ Puffy, dull skin
→ Foggy despite coffee
→ Tired despite sleeping
→ Achy for no clear reason

That's low-grade chronic inflammation.
Jan 28 16 tweets 3 min read
Most people think fasting insulin just predicts Type 2 diabetes early.

It does far more. It tells you:
• Are you misdiagnosed?
• Can you actually reverse this?
• Do you still have beta-cell reserve?

Here’s why fasting insulin reveals your metabolic destiny: Image A client came to me with:

• Fasting glucose: 92
• HbA1c: 5.9
• Fasting insulin: 22 (very high)

Doctor: “You’re just prediabetic.”
Me: “You’re ~2–3 years from Type 2 unless we act now.”
He’s now in remission.
Jan 25 17 tweets 3 min read
Most people choose between 2 bad options:
• Strict fasting → crashes energy, unsustainable
• Eating “normally” → zero metabolic reset

There’s a 3rd option that delivers ~80% of fasting’s benefits with far less suffering. It’s called a fasting-mimicking diet (FMD): Image The fasting paradox: Strict fasting gives metabolic benefits BUT:

• Afternoon energy crashes
• Hunger hormones skyrocket
• Most people quit by day 3–4
• Cortisol spikes (esp. in women)

Standard eating avoids pain, but gives no reset.
Jan 24 15 tweets 3 min read
There are people with diagnosed Type 2 diabetes. And there are people who never test anything.

This thread is for the invisible middle: tired every morning, powered by coffee, exhausted by 6 pm.

Your labs are “normal.” But your metabolism isn’t.
Here’s why Image Standard medical labs use WIDE “normal” ranges.

You can sit comfortably inside them while your metabolism is quietly struggling.

It’s not incompetence.
It’s how the system was designed.
And many people fall into this blind spot.
Jan 22 26 tweets 4 min read
I see this pattern in people with Type 2 diabetes for 5–7 years.

They’ve tried strict DIETS, FASTING, the GYM - yet remission won’t happen.

What nobody tells them: their pancreas is tired and needs a bespoke strategy: Image The truth about long-standing Type 2 diabetes

Early Type 2 isn’t a pancreas problem.

Your pancreas works overtime because your cells stop listening to insulin.
Jan 21 19 tweets 3 min read
Bloating is the #1 gut symptom I see in clinic.

Most people are told to eat clean or cut foods. Yet ~75% don’t improve.
Because bloating isn’t a diet problem, it’s a system failure.

Here’s what actually causes bloating (and how to fix it): Image Most people are advised to:

• Fast more
• Chew better
• Eat more fibre
• Cut FODMAPs

This advice fails because bloating isn’t one problem.
Jan 20 22 tweets 3 min read
Almost 1/3 of my clients hate GYMS.

Hate the culture. Hate the noise. Hate the time.

Yet their fasting insulin drops from 12–14 → 2.5–3.5 mIU/L in 90 days.
No gym.

Here’s how we target visceral fat instead: Image Most people think: “I have insulin resistance → I need cardio or weights.”

Wrong frame.

Insulin resistance is driven far more by biology than gym time.
Jan 18 16 tweets 3 min read
Your cholesterol is “perfect.”
Your blood pressure is normal.
You exercise. You eat well.

Yet your heart attack risk may still be high.

Most doctors miss ONE blood marker: Image It’s called homocysteine.

And it predicts heart attacks and strokes better than cholesterol.

Almost nobody tests it.
Jan 17 13 tweets 3 min read
After 21 years in medicine, I’ve learned something most health content won’t tell you:

The same diet, fasting plan, or supplement can produce opposite results in different people.

Not because of discipline. Because your biology is different. Here’s the science: Image A 2023 Nature Genetics analysis of 1M+ genomes found: Humans are 99.9% genetically similar, yet each person carries 4–5 million genetic differences.

Those differences control how your body processes food, nutrients, and stress.

Same protocol ≠ same outcome.
Jan 16 19 tweets 3 min read
I’ve reversed insulin resistance in hundreds of clients in 90 days.

Not with calorie counting. Not with more exercise.

But by understanding 10 insulin facts your doctor never explains.

Here’s the blueprint: Image If insulin is dysregulated, your body is signaled to store fat.

You’re not lacking willpower.
You’re fighting biology.

That’s why “eat less, move more” keeps failing.
Jan 15 19 tweets 3 min read
Falling testosterone is why many middle-aged men feel weak, tired, foggy, and stuck.

Belly FAT. Poor SEX. More DISEASES. More MEDS.

Here are the 5 hidden destroyers of testosterone & how to reverse them naturally: Image As a doctor, I see this weekly.

Men doing “fine” on paper, but feeling flat, unmotivated, soft, and exhausted.

Low testosterone isn’t rare. It’s becoming the norm.

Here are 5 hidden destroyers of testosterone:
Jan 14 20 tweets 3 min read
Water timing controls your metabolism more than water volume.

Yet most people drink water randomly and wonder why fat loss, energy, and sleep never improve.

This is how circadian-aligned hydration upgrades your metabolism: Image Most people obsess over how much water they drink.

But metabolism doesn’t care about volume alone.
It cares about timing + cortisol rhythm.

Drink at the wrong times → you suppress fat oxidation.
Jan 13 19 tweets 3 min read
Nothing sabotages fat loss, sleep, and energy faster than an unregulated nervous system.

High CORTISOL. Low HRV.
A metabolism stuck in SURVIVAL mode.

Most people spend years chasing the wrong variables. Here’s what actually controls your results: Image Your nervous system has two main operating modes:

1) SYMPATHETIC (survival mode) Fight/flight

↑ Cortisol
↓ Digestion
↓ Recovery
↑ Blood sugar
Jan 12 20 tweets 3 min read
In my clinic, most of my patients who feel tired by mid-morning, crash after lunch, or crave sugar at 4pm

have one thing in common: unstable blood sugar.

Here’s how glucose swings silently wreck energy, and how stability fixes it: Image 1) Energy isn’t about calories.

It’s about glucose delivery to cells, at the right speed, in the right amount.

Spikes give short-lived energy.

Stability gives endurance.
Jan 10 16 tweets 3 min read
Ashwagandha is the most studied adaptogen in both ancient medicine and modern science.

That’s why I included it in my metabolic health supplement.

Here’s how it impacts metabolism, stress resilience & longevity: Image 1) Ashwagandha isn’t a “relaxation herb.”

It’s a stress-response regulator.

And chronic stress is one of the fastest ways to break metabolism.