Thread by @FarvingCo

butyrate DESTROYS insulin resistance

can't lose weight? constantly tired? brain fog?

that's insulin resistance - and it's:
- making you store fat
- blocking your cells energy use
- driving you to diabetes

the fix? butyrate.

in a 2022 JAMA study, butyrate for 6 months improved insulin sensitivity by 25-35% and reduced waist circumference by 5cm

that's INSANE

your metabolism speeds up, energy returns, and fat starts burning.

🧵 here's exactly how to use it (and what else it does)

(1/10) here's what nobody tells you about insulin resistance:

you probably have it and don't even know

signs you're insulin resistant:
- can't lose weight despite diet and exercise
- constantly hungry, especially for carbs
- energy crashes after meals
- stubborn belly fat
- brain fog
- always tired
- skin tags
- dark patches on neck/armpits

your doctor checks fasting glucose and says "you're fine"

but by the time fasting glucose is high, you've been insulin resistant for YEARS

insulin resistance is the root cause of:
- type 2 diabetes
- obesity
- PCOS
- fatty liver
- heart disease
- Alzheimer's

and it starts in your gut

(2/10) butyrate attacks insulin resistance at the source

here's the connection nobody talks about:

damaged gut lining → bacterial toxins leak into blood → chronic inflammation → inflammation blocks insulin receptors → cells can't respond to insulin → glucose stays in blood → pancreas works overtime → fat storage activated

butyrate breaks this cycle:

1. heals gut lining (stops toxin leak)
2. reduces systemic inflammation by 60%
3. restores insulin receptor function
4. improves glucose uptake in muscles
5. reduces liver fat production
6. enhances pancreatic function

it's not masking symptoms

it's fixing the ROOT CAUSE: gut-driven inflammation blocking your insulin signaling

(3/10) the 2022 JAMA study everyone needs to know about:

- randomized, double-blind, placebo-controlled trial
- 54 obese children/adolescents with insulin resistance
- 6 months duration

sodium butyrate: 20mg/kg body weight daily (typically 1-2g depending on weight)

results:
- HOMA-IR (insulin resistance marker) decreased by 1.14 units (p=0.02)
- 25-35% improvement in insulin sensitivity from baseline
- fasting insulin dropped by 5.41 μU/mL (p=0.03)
- waist circumference reduced by 5cm MORE than placebo
- ghrelin (hunger hormone) dropped significantly
- IL-6 (inflammation marker) decreased

published in JAMA Network Open — one of the most prestigious medical journals

zero major side effects, well-tolerated

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client message after 4 months:

"was pre-diabetic (HbA1c 6.2). took butyrate for 90 days. retested: 5.6. my doctor asked what i did. said butyrate. he'd never heard of it"

lost 18 lbs without counting calories — just stopped being constantly hungry

(4/10) here's everything butyrate does for metabolism:

1. improves insulin sensitivity by 25-35%
2. reduces fasting glucose
3. lowers HbA1c (diabetes marker)
4. reduces liver fat
5. decreases visceral fat storage
6. enhances glucose uptake in muscles
7. reduces systemic inflammation
8. heals leaky gut (stops endotoxin leak)
9. improves pancreatic beta cell function
10. normalizes hunger hormones (ghrelin drops)
11. increases fat oxidation
12. reduces post-meal glucose spikes
13. improves energy levels
14. clears brain fog
15. safe for long-term use (6+ months proven safe)

most people only know metformin and berberine

butyrate targets the gut-metabolism connection they're missing

(5/10) here's the mechanism:

your gut controls your metabolism

when gut lining is damaged:
→ LPS (bacterial toxins) leak into bloodstream
→ triggers immune response
→ inflammatory cascade (TNF-α, IL-6 spike)
→ inflammation blocks insulin receptor signaling
→ cells can't respond to insulin
→ glucose can't enter cells
→ insulin resistance

butyrate reverses this:

feeds gut lining cells → cells regenerate → gut barrier seals → LPS leak stops → inflammation drops 60% → insulin receptors work properly → cells respond to insulin → glucose enters cells → metabolism normalizes

you're not just lowering blood sugar

you're fixing WHY your cells stopped listening to insulin in the first place

(6/10) here's the problem:

your gut bacteria should produce butyrate naturally from fiber

but most people:
- don't eat enough fiber
- have damaged gut bacteria (antibiotics, processed food, stress)
- can't produce sufficient butyrate

you're butyrate deficient

that's why gut is leaky → inflammation is high → insulin resistance develops

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supplementing directly:
- bypasses need for perfect gut bacteria
- delivers butyrate where you need it
- works while you rebuild microbiome

but you need the RIGHT FORM:

enteric-coated butyrate (survives stomach acid, releases in colon)

the JAMA study specifically used enteric-coated capsules

regular sodium butyrate gets absorbed in stomach before reaching colon where you need it

(7/10) how to use it for insulin resistance:

dose: 20mg/kg body weight daily (based on 2022 JAMA study)

for adults:
- 150 lbs (68kg) = ~1,400mg daily
- 180 lbs (82kg) = ~1,600mg daily
- 200 lbs (91kg) = ~1,800mg daily

split into 2-3 doses with meals

timing: with meals (better absorption, less stomach upset)

form: enteric-coated sodium butyrate capsules (study used enteric-coated to minimize GI upset)

duration: 6 months for full results (that's what study used) — but many see improvement at 3-4 months

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"is it safe?"

butyrate is what your gut naturally produces

the JAMA study showed:
- no major side effects at doses up to 2g daily
- well-tolerated for 6 months
- enteric coating minimized any GI upset

track progress with blood work:
- fasting glucose
- fasting insulin
- HOMA-IR (insulin resistance calculation)
- waist circumference

(8/10) want even better results?

stack butyrate with:
- berberine 500mg 2x/day — improves insulin sensitivity through AMPK pathway (different mechanism, works synergistically)
- magnesium glycinate 400mg daily — required for insulin signaling, most people are deficient
- brewer's yeast 1-2 tbsp daily — high in B vitamins and chromium (Ray Peat's father reversed his diabetes in the 1950s using this)

(9/10) here's what 6 months looks like (matching the JAMA study):

months 1-2: subtle changes (less hungry between meals, fewer energy crashes, starting to lose hunger-driven cravings)

months 3-4: noticeable changes (weight moving, especially around waist, energy more stable, brain fog lifting)

months 5-6: significant metabolic transformation (25-35% improvement in insulin sensitivity, 5cm off waist, inflammation markers way down)

one client tested baseline and month 4:
- fasting glucose: 108 → 92
- HbA1c: 6.1 → 5.7
- fasting insulin: 18 → 9
- waist: lost 3.5 inches
- lost 22 lbs without counting calories

the JAMA study results are real and replicable in adults

(10/10) 3 reasons butyrate fails for insulin resistance:

mistake #1: wrong dose
the JAMA study used 20mg/kg — for a 180lb adult that's ~1,600mg daily — if you're taking 500mg thinking "it's enough," you're under-dosing — clinical benefits require clinical doses

mistake #2: wrong form
the JAMA study specifically used ENTERIC-COATED sodium butyrate to minimize GI upset and ensure colon delivery — cheap non-coated butyrate gets absorbed in stomach = wasted money

mistake #3: quitting too early
the study ran for 6 months — if you quit at 6 weeks because you don't "feel" different, you're stopping before insulin sensitivity improvement accelerates — your cells are healing, trust the process and retest blood work

if you want to try it:

i use Objective Nutrients Gutmax — 285mg enteric-coated sodium butyrate per capsule PLUS lactoferrin + S. boulardii (the complete metabolic stack)

for 1,500mg butyrate daily: 5-6 capsules split morning/evening

this is the exact stack i've been recommending (butyrate + lactoferrin + S. boulardii) — all in one product

6-month supply (360 capsules) is around $180-240

grab it here:
objectivenutrients.com/products/gutma…

PS: the butyrate is enteric-coated (like the JAMA study used) — it reaches your colon where you need it

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alternative if you want JUST butyrate: BodyBio Sodium Butyrate (500mg per capsule, enteric-coated)
iherb.co/kqG3kCtQ?rcode…

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the 2022 JAMA study used enteric-coated sodium butyrate for good reason — it works and it's well-tolerated

25-35% improvement in insulin sensitivity is MASSIVE

if you're pre-diabetic, have PCOS, can't lose weight, or have insulin resistance — this is JAMA-published science

want the complete insulin resistance reversal protocol?

reply "INSULIN" and i'll send you:

- full butyrate + berberine dosing protocol
- supplement stacking guide for insulin resistance
- what blood work to test (baseline and 6-month follow-up)
- 6-month metabolic tracker
- foods that support butyrate production
- insulin resistance reversal checklist

free now — once 10,000 downloads, becomes paid

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