Thread by @stephenwhittle

1. 1971 GnRH agonists (PBs) discovered

1982 first used to lower sex hormones when treating hormone-sensitive cancers eg prostate & breast cancer. Still the most significant use of GnRH agonists

Mid-1980s were trialed to stop precocious puberty in kids age 0 to 11. This …

https://twitter.com/palaver101/status/1989634560389468346

2. … is still the 2nd most common use of PBs

1990 Netherlands Utrecht GI clinic first used to pause puberty in trans youth.
TY must be
- at serious risk of significant self harm.
- have long term gender incongruence,
- supportive school, parents, & peers
…

3. 2000 NHS GIDS first prescribes to pause puberty in gender incongruent young people

According to Cass by 2021 GIDS had seen 9000 young people

By 2021, according to evidence submitted o the appeal court in Bell v GIDS, the NHS Prescribed PBs to 8% of the..,

4. … approximately 9000 patients assessed ie around 700 service an average of 34 each year. Prescribed at an average age of 15 & 3/4yrs for 12 to 18 months max.

If prescribed correctly under strict clinical protocol as developed in Utrecht, PBs can prevent serious …

4. …, self harming behaviour in a gender incongruent adolescent, allow time for talking therapies, & relieve the child’s stress level helping them to re-engage with family & school

In UK were only used for those with pervasive long term gender incongruence at serious risk.

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