Thread by @1goodtern

For years, people who have been reading the science have been warning that covid infections cause immune system disruption.
Not in a mysterious hand-wavy way.
In a very specific, well-understood biological way:

Covid infections damage B cells and destabilise antibody production.

And covid infections also trigger autoimmune activity in a significant minority of people.

Put those two things together and you get a simple matter of medical science.

If a virus repeatedly injures the immune system in those ways, you would expect a rise in conditions where people cannot make the antibodies they need.

And when people cannot make antibodies, they need something else to keep them alive.

That something is immunoglobulin.

Immunoglobulin is a medical treatment made from donated plasma.
It contains concentrated antibodies.
Doctors use it when a person's immune system cannot protect them properly.

It is used for problems like:

Primary immunodeficiency
Secondary immunodeficiency
Autoimmune neurological conditions

Guillain Barre
CIDP
Kawasaki-like syndromes
And a long list of post-infectious disorders

So if covid causes B cell injury, antibody dysfunction, and autoimmune conditions...

Then you would expect a rise in the conditions treated with immunoglobulin.

And you would expect a rise in the use of immunoglobulin itself.

Maybe even a very dramatic rise.

And that is exactly what has happened.

This graph shows hospital episodes for immunoglobulin (code Y59.3) in people aged 70 plus.
NHS England.
All diagnoses.
Ten years of data:

There has been a steady climb for a while, but the era of endless repeat covid infections has seen it *skyrocket*.

Exactly as predicted.