IntegralAnswers Profile picture
Nov 22, 2025 12 tweets 4 min read Read on X
1/ How did life begin?

Abiogenesis is the idea that life arose from non-living chemistry on early Earth — step by step, not all at once.

Understanding these steps helps explain why life is the expected outcome of the right conditions. Image
2/ Early Earth Context

Earth 4 billion years ago wasn’t a calm blue world. It was a high-energy chemical laboratory — lightning, volcanoes, intense UV, and oceans full of reactive molecules. The environment constantly pushed chemistry forward. Image
3/ Formation of Simple Organics

When energy hits the right ingredients, simple organic molecules form easily.

We’ve replicated this in labs: spark discharges, UV light, and mineral surfaces all drive the creation of amino acids and basic carbon compounds. Image
4/ Increasing Molecular Complexity

Once simple molecules exist, they start interacting. Wet–dry cycles, mineral surfaces, and heat all promote bonding.

Over countless cycles, chemistry naturally drifts toward more complex, information-rich molecules. Image
5/ Why RNA Matters

Before DNA and proteins, early life likely relied on molecules that could both store information and catalyze reactions. RNA fits that role beautifully — and in modern cells, it still carries out ancient catalytic tasks. Image
6/ The Breakthrough: Replication

Life requires replication, but it doesn’t need perfection at first. Early replicators probably copied themselves poorly, but “good enough” to let variation creep in — and variation is the fuel of natural selection. Image
7/ Chemical Natural Selection

Even before cells existed, chemical systems competed. Some used energy more effectively, persisted longer, or copied with fewer errors. Chemistry doesn’t need intent — natural selection emerges anywhere replication + variation exist. Image
8/ Replication + variation = competition.
Systems that were better at surviving and making copies outcompeted others.

Natural selection began long before the first cell existed. Image
9/ Do scientists have every step solved? No. But we’ve recreated many ingredients in the lab: amino acids, nucleotides, lipid bubbles, simple replicators. Nothing requires magic — just chemistry, energy, and deep time. Image
10/ Abiogenesis doesn’t compete with evolution — it precedes it.

Chemistry → self-replication → selection → cells.

Once the first cell existed, evolution reshaped life endlessly.

Want to explore more? See the reference card below. Image
11/ Overview Sources Image
@LyingWrongAgain let me know how I did in creating a simple overview?

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More from @IntegralAnswers

Feb 4
1/ 🧵 A CHD manuscript (Feb 2026) argues aluminum vaccine adjuvants cause ASD and claims it “meets all 9 Bradford Hill criteria.” It’s a narrative synthesis, not a randomized trial or new cohort study. (PDF p1–2) Image
2/ Their headline statistic: ASD prevalence rose “80-fold” and “correlates” with vaccine schedule expansion (r=0.91). That’s a time-trend correlation—useful for hypotheses, weak for causation. (PDF p1)
3/ Why weak? Many things changed over decades (diagnostic criteria, awareness, services). Time-series correlations can be high even when there’s no causal link.
Read 16 tweets
Jan 31
GLP-1 is often framed as a drug target—but it’s first a physiologic gut hormone, released in short pulses when nutrients reach distal L-cells. This thread explains how modern diets silence that system—and how endogenous GLP-1 signaling can be restored. 🧵👇 Image
1/ GLP-1 isn’t just a drug target. It’s a native gut hormone designed to be released in short pulses when nutrients reach distal intestinal L-cells. Modern ultra-processed diets short-circuit this system.

📚 Incretin effect (Nauck et al.) Image
2/ Key insight: L-cells live mainly in the distal ileum & colon. Rapidly absorbed foods never reach them → calories consumed without satiety signaling. The body interprets this as ongoing energy scarcity.

📚 Holst & Deacon, Physiol Rev Image
Read 20 tweets
Jan 31
1/ GLP-1 receptor agonists work—but they bypass normal physiology. This thread reviews how endogenous GLP-1 signaling is suppressed by modern diets, and how gut-centric interventions can restore physiologic, pulsatile incretin release. 🧵👇 Image
2/ The incretin effect shows that oral glucose triggers far greater insulin and satiety responses than IV glucose. This gut-dependent amplification is mediated primarily by GLP-1 and GIP—not by glucose alone. Image
3/ Enteroendocrine L-cells are enriched in the distal ileum and colon. Rapidly absorbed, ultra-processed foods are cleared proximally—delivering calories without activating distal incretin signaling. Image
Read 15 tweets
Jan 30
1/ Chair: [gavel tap] “Good morning. I’m calling the first meeting of the Autism Advisory Board to order. As this is our inaugural session, there are no prior minutes to approve. Welcome, everyone.” Image
2/ Scene: A long federal board table. On the wall: an oversized portrait of Donald Trump, gazing sternly. Beside it, a slightly smaller photo of Robert F. Kennedy Jr..
A glass pitcher of raw milk. Shot glasses at every seat.
3/ Chair: “Before we begin—has everyone read the memo that was circulated ahead of time? The one labeled ‘Marching Orders’?”
Awkward nodding. One member checks the footer for a watermark.
Read 26 tweets
Jan 29
What we know about the newly appointed members — their backgrounds, public positions, and why several selections raise concern from a scientific and public-health consensus perspective.

Thread below. 👇 Image
1/ Sylvia Fogel, MD — psychiatrist working in integrative, PANS-focused care.

⚠️ Caution: immune-driven autism frameworks (PANS/PANDAS) remain controversial and unproven within mainstream autism science. Image
2/ Daniel Rossignol, MD — clinician associated with experimental biomedical autism interventions.

⚠️ Caution: many promoted treatments lack replication, RCTs, or consensus endorsement. Image
Read 23 tweets
Jan 28
1/ 🧵Tuskegee is often treated as a closed chapter in medical history.

But as discussed on Beyond the Noise, its real lesson wasn’t about the past — it was about what happens when medicine decides some lives are acceptable collateral damage. Image
2/ From 1932–1972, Black men with syphilis were deliberately observed but not treated — even after penicillin existed.

Families were harmed. Children were infected.

That was the Tuskegee Study. Image
3/ Guinea-Bissau today is a high-risk setting for hepatitis B.

Prevalence is extremely high, infections often occur at birth, and mothers are not routinely screened — facts emphasized in the discussion. Image
Read 12 tweets

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