James Throt MBBS, MD, PhD, FRCPath Profile picture
Dec 9 6 tweets 2 min read Read on X
You don’t have to be a neurologist to see patterns.

Everyone I know who avoids mitigation looks noticeably different from their pre-covid selves. In temperament, in consistency, in emotional regulation, in decision making.

The changes are everywhere. People just normalised them
A key problem we have is that neurological changes often impair the very systems needed to notice those changes.

It’s an anosognosia-like loop.

The more dysregulated someone becomes, the more convinced they are that nothing is wrong.
At population level, impairment camouflages itself.

If everyone’s executive function declines a little, the new baseline feels ‘normal’.

People compare themselves to the surrounding decline, not their pre-2020 selves.
“I feel fine” tells you nothing.

Biology doesn’t care about subjective impressions, especially when the frontal systems that detect internal change are the ones affected.

Symptoms aren’t the same as damage, and lack of symptoms isn’t the same as health.
And, by the way, the earliest warning signs aren’t academic or intellectual… they’re behavioural.

Irritability, impulsivity, inconsistency, reduced foresight, emotional volatility.

Executive function cracks long before anything shows up on a formal test.

Take time to observe.
Most people are contracting 1-2 infections p/year, each one accelerating biological ageing through neurotropic injury, vascular damage & cumulative immune dysfunction.

Life expectancy isn’t increasing, it’s contracting.

And show me someone who wants to work until they’re 120 😂

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More from @JamesThrot

Nov 26
If you still believe COVID left the population “unchanged”, open a dating app. It sounds absurd, but stay with me here.

The cognitive bluntness is so widespread that the dating platforms themselves have had to acknowledge behavioural deterioration since 2020.

It’s not subtle🧵
Since 2020, apps report the same pattern: shorter messages, less reciprocity, fewer follow-ups, lower meet-up rates & a collapse in sustained conversational ability.

This isn’t just “people being tired”. It’s a measurable degradation of attention, initiative & social cognition.
The cause?

- repeated COVID infections impairing cognitive stamina/reward processing

- chronic low-grade fatigue

- dopamine systems altered by COVID/crises

- widespread emotional numbing

- increased avoidance as default coping mechanism

All the above = social “flatlining”
Read 17 tweets
Nov 24
Oh they know.

The reason any utter of the word “COVID” is met with awkward silence, abrupt subject changes, or mockery is no coincidence.

That’s what denial looks like when the stakes are too high for people to admit what they already sense.

You’re letting them off too easily.
Universal internet access & AI at everyone’s fingertips in year 6/7 of COVID. Yet we’re still pretending the public is merely “uninformed”?

This isn’t a knowledge gap, it’s deliberate avoidance, a psychological defence to shield people from the consequences of their own choices.
And here’s the part people pretend not to understand: we don’t rely on governments or legacy media for any other major issue

Nobody waits for official guidance to form opinions on Gaza, Epstein, climate collapse, corruption/surveillance. People “do their own research” constantly
Read 6 tweets
Nov 16
There’s a pervasive misunderstanding in conversations about COVID’s neurological impact.

Many people assume that saying “frontal lobe damage reduces empathy” means everyone who’s had COVID instantly becomes amoral & unethical.

That’s reductionism at its finest. 🧵
Frontal lobe impairment is not an on/off switch.

Someone with naturally high empathy can still appear extremely empathetic, even if their capacity has measurably declined.

It’s a shift, not a reset.
At the population level, repeated SARS-CoV-2 infections subtly alter impulse control, moral reasoning and susceptibility to manipulation.

This doesn’t mean every individual loses morality, but society-wide trends can shift in meaningful ways.
Read 6 tweets
Nov 15
Let’s talk about one of the most dangerous and under-discussed consequences of SARS-CoV-2: neurological damage. More specifically, frontal lobe dysfunction.

This is being deliberately downplayed, in part due to a misguided weaponisation of “ableism” discourse. That’s a problem🧵
Here’s the truth.

SARS-CoV-2 is a neurotropic virus. It can invade the central nervous system, either directly or through inflammatory damage.

It’s been detected in brain tissue, and it can cause lasting neurological impairment.

This is not speculative.
The frontal lobe governs executive function, impulse control, empathy, moral reasoning & inhibition. Damage here can lead to:

- Aggression
- Impulsivity
- Gullibility
- Bigotry
- Loss of social inhibition
- Apathy
- Antisocial traits

This is basic neurobiology, not ableism.
Read 12 tweets
Nov 11
Calling it “ableist” to discuss SARS-CoV-2 related frontal lobe dysfunction misunderstands both neurology & ethics

Frontal lobe injury can cause apathy/disinhibition/moral blindness & aggression since these are the functions the region governs

This is neurobiology, not stigma🧵
Autism/ADHD/PTSD etc are forms of innate neurodiversity. Stable, lifelong neurotypes

Frontal lobe injury from COVID is acquired neurodegeneration. A progressive erosion of neural circuits governing empathy, foresight, inhibition & moral reasoning

Conflating the two erases both.
Frontal lobe damage, whether from traumatic brain injury, dementia or viral neuroinflammation, is well known to alter personality & behaviour.

It’s not a moral judgement. It’s anatomy.

The prefrontal cortex is literally the “brake” that tempers impulse, aggression & egocentrism
Read 14 tweets
Nov 10
Cognitive decline from repeated SARS-CoV-2 infections & the rise of AI tools like ChatGPT = a perfect storm.

Here’s why this could reshape society in ways most people aren’t ready for 🧵
Repeat infection = cumulative damage to the brain. Particularly the frontal lobe, which governs empathy, foresight, impulse control & reality testing.

That’s the part of the brain that lets you question, reflect & doubt. Without it, a person becomes gullible, rigid & manipulable
Now layer on the rise of AI chatbots

People increasingly use them to write, think, argue, even feel for them.
And these models are designed to appease, to mirror your biases, validate your delusions and give you the emotional texture of understanding without any of its substance
Read 9 tweets

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