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Efthymios Kalafatis Profile picture
@lifeanalytics
Dec 18 • 9 tweets • 3 min read • Read on X
1/ Here are some slides from my upcoming video : Have we been missing key aspects for diagnosis and key mechanisms in #MECFS research ? Do certain metabolic bottlenecks NEED to be looked at more closely ? @OpenMedF @PlzSolveCFS @weandmecfs @MEAssociation. Let's begin :
2/ In the attached table (will link the source at the end) we read : Disorders of Nitrogen containing compounds. On the right, @OpenMedF currently looking at this (snapshot from MEPedia). Image
Image
3/ From the same file (left), we read Hemochromatosis and Wilson's disease.Attachments on center (from latest GWAS study) and a #LongCOVID study for Wilson's disease patients (right) : Image
Image
4/ From the same file (left) : Mentions on Carnitine Palmitoyltransferase deficiency 1 & 2. On the right, relevant study. Image
Image
5/ On the left, Part 6 (again - posted above). Mentions on Porphyria and Hemin (annotated ellipse). On the right, a post by @MEAssociation related to Hemin and Porphyria Image
Image
6/ As I am not a medical professional I would like to ask : Should #MECFS patients be checked for the conditions appearing on the file ? Unfortunately there are many conditions and I hypothesize that many entries could be applicable to certain patients.
7/ If such bottlenecks exist , their management may be crucial for any symptom improvement plan. In my upcoming presentation these metabolic bottlenecks will be discussed along with other potentially important research targets.
8/ The file I mentioned is from the attached study and can be found here : iembase.org/gamuts/store/d…
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More from @lifeanalytics

Efthymios Kalafatis Profile picture
Dec 5
1/ This is a thread on the results from #LOCOME project (links at the end) which involved work by @precisionlifeAI. Excited to say once again that when different methods identify the same "hotspots", it raises our confidence about these findings. Let's see why :
2/ In the study by @precisionlifeAI a total of 259 genes were identified as core genes as shown below. Observe the associations discussed (Inflammation, Cellular stress response etc). The question is : What can we make out of this gene subset? cc @Michaeltikus Image
3/ Here is a snapshot of these genes with some of them being annotated. The annotated ones are ABCA1, CYP7B1, CH25H, ABCC6, UGGT1 Image
Read 11 tweets
Efthymios Kalafatis Profile picture
Nov 26
1/ This study on #LongCOVID is very important (link at the end), thanks to @Gmwetz for mentioning it ! From the study (left) , clear mention on N-Linked glycosylation. On the right, document specifically mentioning N-Glycans and N-Linked glycosylation I circulated in 2017. Image
Image
2/ We now should be looking forward to results of this study which checks glycosylation in #MECFS patients (cc @weandmecfs ) : wwtf.at/funding/progra…Image
3/ Why are these findings important ? Because they point to problematic N-Linked glycosylation. From the study : "Our findings of increased mannosylation on plasma EVs is suggestive of ongoing glycosylation pathway abnormalities that may play a role in Long
COVID pathology".
Read 10 tweets
Efthymios Kalafatis Profile picture
Sep 16
1/ Another coincidence given my recovery ? Below is a causal hypothesis and interventions using the best performing #AI model (Full info included at the end of this thread). The causal hypothesis is for an "unknown syndrome" (however, findings related to #MECFS were used) Image
2/ So what are the proposed interventions ? A part of the answer is shown here, observe the annotated ones and also that a specific order of interventions is used : Image
Image
3/ The reasoning engine explains why such order is important. Note that we begin by restoring the cell membrane (cc @tamararivc ). Steps 1 & 2 are shown above. ISR = "Integrated Stress Response" Image
Read 8 tweets
Efthymios Kalafatis Profile picture
Aug 13
1/ This is a thread on the use of 5 #AI reasoning engines in order to better understand #MECFS given the latest results by @DecodeMEstudy #GWAS study. I want to express a huge "Thank you" to @genspark_ai : Without your tools this would have not been possible!
2/ I wanted to simulate a committee of 5 "experts" hypothesising on what is behind #MECFS while presenting different layers of information. Then, each "expert" checked hypotheses of other "experts" and gave which one is best. Image
3/ The clear winner was the hypothesis by @OpenAI #ChatGPT5 Pro. *All* "experts" agreed that it is the most concise of all others. During the process, novelties on reasoning were also identified. For example, relevance of Ubiquitin Proteasome System was picked only from #Deepseek
Read 6 tweets
Efthymios Kalafatis Profile picture
Jul 1
1/ I would like to share my personal experience with LOLA (L-Ornithine / L-Aspartate) supplementation and also an update from using it. When Dr Wenzhong Xiao first mentioned it to me, I told him about my first experience from using it which was in 2019. Back then, LOLA ..
2/ ...did not seem to "feel" right for me. I did not feel unwell but I had some strange lightheadedness after taking it so I decided not to move forward in further supplementing it. Given our recent publication (see below) & patient comments I decided to try it again, this time.. Image
3/ ...using a different LOLA supplement brand from the one I used. In 2019, I did not have many buying options for LOLA (which is used for hepatic encephalopathy). I can definitely now say it is working for me. Total dosage is 2 grams / day, spread in 4 doses.
Read 5 tweets
Efthymios Kalafatis Profile picture
May 12
1/ 🧵 I am excited to share the latest results -as a hypothesis- , using computational #AI analysis applied to #MECFS and #LongCOVID research. To the best of my knowledge, this application of #AI is the first of its kind in #MECFS and #LongCOVID research.
2/ 🔍 How it was done : First, several AI models were given relevant information on what we know from various studies. Particular weight was given to replicated findings. Most common symptoms of #MECFS and #LongCOVID were provided and also a detailed list of syndrome triggers.
3/ 👉 Key point : Every mention of #MECFS, #LongCOVID, #PostViral, #PostInfection was removed from the text of the studies as these entries could potentially bias the reasoning process. The prompt given mentioned about an "unknown syndrome".
Read 16 tweets

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