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Efthymios Kalafatis Profile picture
Efthymios Kalafatis
@lifeanalytics
Data Scientist, Patent owner of Artificial Intelligence-assisted methodology for Health Research. Tweets are mine/not medical advice or endorsements.
Jul 25, 2023 • 10 tweets • 3 min read
1/ We now look at the 4th hypothesis named "Could vascular damage caused by massive
inflammatory events underlie a relapse/recovery
phenotype of ME/CFS and Long COVID?" from @JeffLubell_C19 which can be found in the @patientled patient-generated hypotheses. 2/ The hypothesis suggests that a relapse/recovery pattern takes place among #MECFS and #LongCOVID patients and also discusses associations of hypermobile #EhlersDanlos, chiari malformation,tethered cord syndrome and mast cell activation with these syndromes.
Jul 10, 2023 • 15 tweets • 4 min read
1/ This is a 🧵 for being in remission from #MECFS since 2015. Below, is the email I sent to selected #MECFS researchers (Dec. 2015) which I would like to provide as evidence, as this hypothesis is unpublished (Some parts omitted including recipients and specific regimen steps). 2/ The email discussed a hypothesis that for #MECFS and other syndromes (shown in red rectangle) a common factor is liver injury. Observe also mentions on oxidative stress (cc : @cstroeckw) and a "vicious cycle" being at play...
Jun 3, 2022 • 5 tweets • 3 min read
🧵 On connective tissue (CT) disorders, #MECFS & #LongCOVID. I came across recent tweets by @ahandvanish and @Be_Kinderr related to a dutch study that found CT abnormalities in LC patients. 2/ Searching for "connective tissue" using an information retrieval system I got the following ranked results : Observe that "mast cells" are highly ranked. Note that MCAS (Mast Cell Activation Syndrome) is being frequently mentioned among LC & ME patients
Apr 7, 2022 • 8 tweets • 3 min read
1/ @VirusesImmunity, some thoughts for a "Liver Injury hypothesis" that i hope you and other researchers will look at for #MECFS and #LongCOVID. After watching your interview, i used an #InformationRetrieval (IE) system built specifically... 2/...for the purpose of researching #MECFS and -now- #LongCOVID. You mention -among other topics- low cortisol, reduced fatty acid oxidation, mitochondrial dysfunction, GPCRs,CCL11, traumatic brain injury. These topics were entered to the IE system..
Dec 30, 2021 • 5 tweets • 4 min read
1/ This is a thread on the application of various analytical methods to findings from @resiapretorius related to microclots in #LongCOVID patients to help find potentially interesting associations. Tagging also @ahandvanish @maosbot @doctorasadkhan 2/ An information extraction system was used to identify most related medical topics to the latest work by @resiapretorius (see snapshot). The query used is shown in red, results are shown in a blue rectangle. Some -hopefully- interesting observations follow :
Apr 23, 2020 • 4 tweets • 2 min read
(1/4) #MECFS is a multi-systemic disease where we are trying to put the pieces of a huge puzzle together. In the Network Analysis shown below Lysine plays a central role. Dr Ron Davis found high Lysine levels in #PwME. (2/4) Next step is to try and find why this is so. There are a number of concepts (nodes) next to Lysine. Some of them are expected to be there. Others (such as Osteopontin) may not be expected or known to a researcher. We many then find using the associations shown above...