Dalton (Analyze & Optimize) Profile picture
Jan 16 β€’ 9 tweets β€’ 4 min read β€’ Read on X
A striking study showed that vitamin B3 reversed every sign of skin aging measured within a few weeks.

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They used a form of vitamin B3 called niacinamide, which is a derivative of niacin or nicotinic acid - the standard form we get from food.

This form of B3 gets more efficiently converted into a molecule called NAD+, which is where much of vitamin B3's activity lies.

People applied a "pea sized" amount of 5% niacinamide to the face 2x a day.

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Niacinamide (B3) substantially reduced the presence of age spots in the skin.

They continued to disappear with time, maxing out at 12 weeks.

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Niacinmiade reduces wrinkles, too.

Again, the biggest effect was after 12 weeks, with a marked reduction in wrinkles.

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Skin yellowing was improved with niacinamide.

Another relatively common sign of skin aging, which happens when proteins in the skin become glycated (AGEs).

Niacinamide stopped it.

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Skin elasticity is also typically worsened with age as a result of loss of collagen and elastin proteins.

Niacinamide was shown to improve this property as well.

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They noted that the production of glycosaminoglycans were 2-3X higher in aged skin cells.

These are important structural components of the skin but become overproduced as the skin ages and becomes damaged.

Niacinamide was able to reduce this process in cells.

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Niacinamide works by several different mechanisms to counteract aging in the skin, it's an absolute powerhouse.

Supplying sufficient NAD+ is the key here.

➜ Direct antibacterial / antifungal
➜ Antioxidant effects - preventing cell damage / death by supporting NADPH production, which recycles various antioxidants
➜ Energy metabolism - NAD+ from niacinamide is one of the fundamental components of mitochondrial
➜ Supports DNA repair through supplying NAD+ to sirtuins and PARP enzymes
➜ Anti-inflammatory effects - high levels of niacinamide can inhibit key inflammatory pathways, reducing damage
➜ Inhibits senescence - this is the process of cells stopping their division and become dysfunctional + inflammatory, in skin cells this leads to decreased output of collagen, elastin and other structural components.

It's mainly studied topically but being sufficient in it through the diet should be the first step here - meat and mushrooms are some of my favorite sources.

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If you want to get some personalized help from us with ANY of your health goals, we’re taking clients virtually worldwide every day at PRISM. Book a free call here for more: go.prism.miami/consultation

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More from @Outdoctrination

Jul 22
You can literally live longer, become stronger, lower inflammation & protect your brain without supplements, drugs, diet or exercise.

Your choices & mindset measurably dictate your health more than you realize.

We have the science to prove it (THREAD):Image
THINKING about training increases strength.

People instructed to simply imagine the process of exercise had 10-30% increases in strength. Image
If you imagine you will become stronger, then you will.

The most recent compilation of experiments showed that just thinking about different exercises increases strength,

in some cases by well over 100%. Image
Read 19 tweets
Jul 21
N-Acetylcysteine is a mental health marvel.

From anxiety, to ADHD, autism and even suicidal depression, it acts as a master mood stabilizer.

Let's talk about the benefits of NAC, the science and how to use it yourself:Image
N-Acetylcysteine cuts OCD in half in clinical study.

Titrated up to 2.4g per day (as add on treatment).

NAC works here by reducing glutamate release from neurons.

This glutamate is responsible for "excitatory" brain processes, which in excess can contribute to OCD. Image
N-Acetylcysteine cut depression by >60%, anxiety by 50% in this paper.

1.2 g per day.

Excess glutamate in distinct brain regions can contribute to these feelings.

NAC's ability to lower it in the ventrolateral prefrontal cortex contributes to its antidepressant and anti-anxiety effects.Image
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Read 15 tweets
Jul 21
Cortisol was completely stopped under stress with a simple & cheap supplement, according to a fascinating study.

(🧡1/7)Image
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This study was published in 2016, evaluating the anti-stress properties of L-THEANINE.

This is an amino acid found naturally in green tea.

People were given either a mix of:

➠ L-theanine (200 mg)
➠ L-alpha glycerylphosphorylcholine (alpha GPC; 25 mg),
➠ Phosphatidylserine (1 mg)
➠ Micronized chamomile (10 mg)

Or placebo, alongside a cognitive assessment.

While the drink did have these other ingredients, they are far below (<1-10%) their typical dosing - so their impacts were likely small or negligible.

(2/7)Image
People consuming the L-Theanine drink reported markedly lower stress within the first hour.

They actually felt less stressed with the L-theanine, than they did prior, even though they were taking this assessment.

(3/7) Image
Read 9 tweets
Jul 13
The power of GLYCINE is seemingly never-ending.

For something so cheap it has the power to literally extend lifespan, stop inflammation, heal your gut and send you into deep, restful sleep.

Let's get into the science, the incredible benefits & how to use it yourself (THREAD):Image
Glycine increases lifespan, promotes longevity in animal studies.

8% increase in lifespan here.

β˜† Anti-inflammatory
β˜† Controls gene expression
β˜† Clears homocysteine (toxic)
β˜† Supports glutathione production (antioxidant)
β˜† Precursor to creatine (muscle + brain fuel)
β˜† Collagen synthesis
β˜† Promotes autophagy

It counteracts the pro-aging effects of excess methionine, a major component of muscle meat.Image
The combination of glycine + NAC is especially powerful.

Combining them increases lifespan by ~25% in experiments.

They synergize to create the master antioxidant glutathione.

βœ“ Reduces organ damage
βœ“ Preserves mitochondrial function

even at low amounts.

Image
Read 21 tweets
Jul 12
Vitamin C can reduce cortisol by ~40%, according to a critical new study.

(🧡1/7)Image
This study was published last year, examining the effects of 1g of vitamin C per day in people with high stress hormones.

Vitamin C is known to be stored in the adrenal glands and released in times of stress.

A few previous studies suggested adding vitamin C could lower cortisol.

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There were 3 groups.

Group 1: high cortisol + normal DHEA-S

Group 2: high cortisol + high DHEA-S

Group 3: normal cortisol + high DHEA-S

DHEA is an anti-stress hormone, and its levels rise in the early stress response to balance the effects of high cortisol.

Each group either got 1g of vitamin C or placebo.

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Read 9 tweets
Jul 11
Blocking / lowering prolactin stimulates hair growth AND reverses graying in early studies.

This is an antibody in trials right now that acts against the prolactin receptor.

What causes high prolactin?

β—‡ Prolactinomas
β—‡ High estrogen
β—‡ Low dopamine
β—‡ High serotonin
β—‡ Various stressorsImage
Read 4 tweets

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