Dalton (Analyze & Optimize) Profile picture
Jan 21 15 tweets 8 min read Read on X
CANDIDA: The cause of your terrible gut health and fatigue that your doctor has no idea how to fix.

Here’s how to know if you have it, what causes it and what to do about it (🧵1/13):Image
◇ A coated tongue (more towards the front)
◇ IBS
◇ Crohn’s or UC
◇ Bloating
◇ Brain fog
◇ Gas
◇ Nausea
◇ Constipation
◇ Diarrhea
◇ A lack of appetite
◇ Fatigue

Are all signs of a fungal overgrowth, the most common of which is Candida. Image
Unfortunately, testing for Candida can be a futile effort.

Common testing methods are:

Candida antibodies (IgG, IgM, IgA): Tests the presence of immune proteins that recognize Candida in the blood. Indicative of exposure, but can also indicate past exposure (not present) and not telling whether or not it is causing your symptoms.

Stool: Tests the presence of yeast (or Candida) in your poop. In theory this is the best, but not indicative of Candida in the upper part of your digestive tract, and also not indicative of Candida in the lining (mucosa) of your gut, just in the poop. Candida also normally exist in the gut without causing problems, so again, not telling whether or not it is causing your symptoms.

Aspirate: Tests the presence of Candida in the juice of your small intestine. Not indicative of what is happening in the lower gut, and also rarely done in practice.

Since testing is so unreliable, going off of symptoms is really the best strategy.

HOWEVER, this can backfire if you are not careful, for reasons I will explain later.
Candida can be behind IBS - antifungals can reverse it.

Candida can drive inflammation, gas and other processes in the gut that contribute to IBS pathology.

People with IBS have higher levels of this fungus,

but treatment with fluconazole or nystatin can improve symptoms.

Inflammation in the gut can also predispose to greater candida colonization.

Noticing a pattern?

Inflammation and poor gut health can cause Candida overgrowth,

and Candida can cause inflammation and ruin gut health.

So, how can we stop this cycle?Image
We all have Candida in our guts to some extent.

Issues arise when it starts contacting or invading our cells, or worse - passing through the gut.

This becomes more likely with:

◇ Bacterial overgrowth / dysbiosis
◇ Suppressed immunity
◇ Chronic gut inflammation

That means in order to solve Candida, you MUST nail down the basics of your gut health,

before thinking about anything specific for it.

I suggest checking out my thread on gut health overall for more on that: x.com/Outdoctrinatio…Image
ESTROGEN is one of the key promoters of Candida.

This is why yeast infections / UTIs are common in women, especially during high estrogen portions of their cycle or during pregnancy.

If you have Candida, you MUST focus on lowering estrogen.

Estrogen master thread here. Image
Low stomach acid and a slow gut can cause Candida overgrowth.

Stomach acid is our primary defense against excess microbial growth - bacteria and fungi like Candida.

For increasing stomach acid, tools like:

◇ Vitamin B3
◇ Coffee
◇ Bitters
◇ Vinegar
◇ Salt

Will be useful.

If your gut motility is slow, then you just leave the microbes more time to linger and feast.

Some tools to help improve motility:

◇ Coffee (even decaf)
◇ Senna
◇ Raw carrot
◇ Magnesium
◇ Baking soda
◇ Cascara
◇ Triphala
◇ Sodium butyrate
◇ Mastic gum
◇ Vitamin B1

Now it's important to understand that these tools are not always fixing the root cause, but they are helpful in the interim if you're trying to overcome an infection.Image
Candida thrives in an environment rich in simple sugars.

HOWEVER, the real problem is CHRONICALLY high blood sugar - in other words insulin resistance.

People with poor glucose metabolism are susceptible to fungal overgrowth.

Adding tons of refined carbohydrates to the diet does not lead to Candida overgrowth in healthy people (in clinical trials).

This is likely because most simple sugars get absorbed rapidly, before Candida gets a chance to feed on them.

There is some evidence to suggest a lower simple sugar diet can help in some people, when combined with antifungal drugs.

The immune system needs carbs to kill Candida

Candida can outcompete the immune system for carbs, leading to impaired immune defense,

but giving a sugar drink improves survival in animals after infection.

If the low carb approach isn't working, it might not be worth it.

You need to focus on the candida, but also your own host health + immunity.

Carb restriction can impair thyroid function, raise cortisol and other potentially negative effects that can backfire when trying to deal with Candida.Image
Vitamin D is a powerful anti-fungal agent.

Vitamin D is absolutely vital for a fully mature and functioning immune system.

It also produces proteins that are directly antifungal.

It reduces all forms of Candida growth, virulence and biofilm formation.

Image
Lacto / bifido bacteria (in probiotics) in general tend to outcompete and are protective against fungal overgrowths.

Probiotics can rapidly reverse Candida.

In this study, a lacto/bifido blend reduced Candida substantially just within a few weeks. Image
Lactoferrin is an antifungal against Candida.

Lactoferrin is a protein found in milk (especially raw milk and colostrum) with various protective benefits for the gut.

It helps chelate IRON which is important for all pathogens to grow, including fungi like Candida. Image
Some other antifungals:

⇨ Methylene Blue
⇨ Pau D'arco
⇨ Niacinamide
⇨ Aspirin
⇨ Oregano oil
⇨ Rosemary
⇨ S. Boulardii
⇨ Coconut oil
⇨ Raw honey
⇨. Zinc
⇨ Grapeseed extract
⇨ L. Rhamnosus
⇨ Sulfur (flowers of sulfur)

These will be vital.

Not saying to use them all at once, or that they alone will fix it, but they will be a huge help.

You also can use prescription antifungals,

and while these are more powerful for killing the fungi,

they can ruin the microbial environment in the gut and the immune system.

This would be my last resort once the above resources are exhausted.
The thing is, while Candida is highly publicized and talked about,

most gut issues are bacterial in nature.

It is much less common for issues to be driven by Candida than by bacterial dysbiosis,

and even if they are - the bacteria control Candida's proliferation.

Since tests can be misleading or a waste of money and time, I would focus on fixing the bacteria in the gut before thinking about Candida.

The symptoms can be nearly identical, besides a few differences.
If you want to get some PERSONALIZED help from us with ANY of your health goals, we’re taking clients virtually worldwide every day at PRISM. Book a free call here for more: go.prism.miami/consultation
If you’re interested in getting lab testing, we offer a ton of different tests you can get without even needing to go to a doctor below. 10% off using code “ANALYZE” at checkout. revelationdiagnostics.com

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More from @Outdoctrination

Jun 11
The vitamin that NEVER gets talked about has more benefits than you can even count.

Mental health, boosting metabolism, gut health and even increasing testosterone.

Let's talk about the marvelous VITAMIN K2:Image
This study showed that Vitamin K2 could treat depression.

K2 (as MK-7) improved depression at just 90 ug/day, a pretty puny dose, in 8 weeks.

K2 fulfills multiple roles in the body that gives it this effect.

The effect is very noticeable in my experience, it's an instant mood lifter.Image
Low levels of Vitamin K nearly DOUBLES the risk of suicide attempt.

Vitamin K2 enhances mitochondrial energy production.

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Magnesium is often a missing link in tinnitus - and supplementing it can alleviate the ringing sensation. (🧵1/8)Image
A short report in 2016 showed that serum magnesium levels were lower in people with tinnitus.

Keep in mind this was serum levels, typically the last place for magnesium to become depleted in.

But is this correlation or something real? Image
Well, a trial from 2011 examined this.

They gave people 532 mg of magnesium (mainly as oxide, which is poorly absorbed) who had tinnitus for 3 months.

The results showed some serious promise. Image
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Jun 7
A captivating study showed that zinc carnosine is protective for leaky gut and stimulates repair of the gut lining. (🧵1/7)Image
This was published in 2007 in the BMJ's GUT journal.

They actually ran multiple studies and published it in this one paper:

➜ A human study on leaky gut (intestinal permeability)
➜ Studies on repair and cell migration
➜ Analysis of gut damage and structure Image
Zinc carnosine was able to prevent leaky gut (intestinal permeability) completely.

People taking 75 mg of it a day were shown to have no difference in the lactulose / rhamnose ratio in the urine.

Those in placebo showed a marked increase.

If there is high lactulose relative to rhamnose, that is indicative of permeability in the gut since lactulose is a large sugar that should not pass through.Image
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Jun 7
If you want to live longer, read this.

These are the 7 KEYS TO EXTENDING LIFESPAN in research (🧵1/8):Image
The Basic Principle of Longevity

We can think of life fundamentally as growth + repair phases.

Growth phase: muscle building, tissue regeneration, immune cell proliferation, injury repair, and more. Very important.

Clean up phase: breakdown of damaged components, fat loss, fine-tuning immune cells

We need both, but in research it's typically thought of as:

Aging: excessive growth + damage accumulation

Lifespan promoting: growth restriction + damage removal

Most research focuses on the clean up phase for lifespan extension, and that's likely because we live in a time where signals for the growth phase tend to be abundant.

This is true, even in experimental animals - even "normal" animals are typically overfed.

We also need the growth phase for health, it coincides with having high thyroid, high T, low cortisol and more.

So keep that in mind as we go through the below - this is not to say that these always perfectly mimic real world conditions, but we will be going through what experimentally drives the aging process and what extends lifespan.

True health is unlocked when your body can go deep into the growth phase and deep into the cleanup phase, not being "stuck" in either phase, which leads to problems.Image
#1 Insulin sensitivity / IGF1 signaling

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This is one reason why being overweight or obese is so bad, because it causes you to become insulin resistant, where your insulin is constantly elevated.

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This is also one reason why caloric restriction is the gold standard of lifespan extension. It's the simplest way to reduce the chronic growth signaling.Image
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(🧵1/8)Image
Astaxanthin is a powerful antioxidant found in red seafood like salmon and shrimp.

If you're unfamiliar, I've written more about what it is below.

This study pooled together all of the human studies done on astaxanthin.

Let's go through them.

(2/8) Image
One of the most striking showed that over 8 weeks, astaxanthin:

➜ Reduces wrinkles
➜ Improves skin elasticity
➜ Reduces age spots
➜ Increases skin hydration
➜ Reduces sebum production

used at 6 mg orally per day, here they combined it with topical astaxanthin.

(3/8) Image
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Jun 5
N-acetylcysteine (NAC) was shown to reverse brain damage from aluminum in a critical study.

(🧵1/8)Image
Animals were put into 6 groups - either getting aluminum or NAC or both.

The aluminum was administered as aluminum chloride, and it was done so orally.

This is important because roughly only 0.5% of oral aluminum chloride is absorbed, so the real effective doses the animals received were far less than than the 100 mg / kg.

This is still a high dose, but aluminum is known to accumulate in tissues.Image
Animals had severely impaired memory performance with the aluminum, but this was improved with NAC.

The morris water test trains rats to find a hidden platform in pool.

The latencies (times) is how long it takes to find it on a given day.

Less time = better memory.

As you can see, the high dose NAC almost completely reversed the memory impairment from aluminum.Image
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