THE NANOPARTICLE REVOLUTION: Re-educating the Blood-Brain Barrier.
New research from a Spanish and Chinese consortium has unveiled a "supramolecular drug" capable of repairing the BBB's natural waste-disposal system to treat Alzheimer’s.
A thread on the future of AD therapy.
1/ The Problem: In Alzheimer’s, the Blood-Brain Barrier (BBB) stops working as a filter and starts acting as a wall.
Toxic proteins like Aβ build up because the brain's natural "trash shoot" is broken.
The Solution: Activating the endogenous efflux pump.
2/ This breakthrough is a global effort. By combining material synthesis expertise from China with biological validation from Spain, researchers created a nanoparticle that doesn't just deliver drugs—it heals the barrier itself.
1/7 In early Dec 2021 → Apr 2022, vaccines + boosters were widely available in the US. The key question isn’t “who died” in raw counts—it’s age-adjusted death RATES by vaccination status.
2/7 Age-adjusted death rate ratio (RR) = (death rate in unvax) ÷ (death rate in vax/boosted), standardized for age. That’s how you compare “like with like” when risk rises steeply with age.
3/7 CDC (25 jurisdictions) during Delta (Oct–Nov 2021): unvax COVID death rates were 53.2× higher than fully vaxed + boosted (age-standardized). That’s the runway into early Dec.
1/ If you’ve ever seen someone post a VAERS screenshot and say: “Look how many people died after this vaccine!” This thread is for you. Let’s walk through what VAERS is — and what it is not.
2/ VAERS is a passive reporting system. Anyone can file: • Doctors • Nurses • Patients • Parents • Manufacturers. It’s designed to detect signals, not determine whether a vaccine caused something.
1/ Cardiometabolic health = integrated function of vascular + metabolic systems that drives ASCVD, HF, CKD, MASLD, and T2D risk. Domains: adiposity distribution, BP load, atherogenic particles, glycemia/IR, ectopic fat, end-organ injury.
2/ Why it matters: cardiometabolic risk is additive. Mild “borderline” shifts across several domains (BP + ApoB/non-HDL + A1c + waist + ACR) can equal high risk—even when no single value looks dramatic.
1/ 🧵 A CHD manuscript (Feb 2026) argues aluminum vaccine adjuvants cause ASD and claims it “meets all 9 Bradford Hill criteria.” It’s a narrative synthesis, not a randomized trial or new cohort study. (PDF p1–2)
2/ Their headline statistic: ASD prevalence rose “80-fold” and “correlates” with vaccine schedule expansion (r=0.91). That’s a time-trend correlation—useful for hypotheses, weak for causation. (PDF p1)
3/ Why weak? Many things changed over decades (diagnostic criteria, awareness, services). Time-series correlations can be high even when there’s no causal link.