1/ Finally I can share this : I propose the investigation of Fucoidan (LMWF) using a RCT for the amelioration of Post Exertional Malaise -and possibly of other symptoms- of #MECFS and related syndromes. Here is why (make sure you read Disclaimer at end of thread) :
2/ In previous posts, I shared that efferocytosis is becoming more relevant as more results from studies are coming in. At the time of this post here is how it looks like with relevant studies . Link to the file : docs.google.com/spreadsheets/d…
3/ It appears that Fucoidan matches with many key aspects that are important for proper efferocytosis. ABCA1, LXR, GAS6 / MerTK are regulated by Fucoidan (all these concepts were found by studies - see previous post). Some relevant studies regarding fucoidan shown below :
4/ It is also possible that an approach using multiple compounds is needed for better results, for example Fucoidan + Pro-resolving mediators (SPMs) and/or PPAR agonists. Moreover Fucoidan could be -according to AI below (may contain errors) - a compound to improve Fibrinolysis.
5/ Disclaimer : This thread DOES NOT suggest in any way to supplement with Fucoidan, SPMs, or PPAR Agonists. Talk to your Doctor before any intervention ! Further research is needed as to whether these compounds are indeed beneficial to patients !
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