tern Profile picture
Mar 20 24 tweets 3 min read Read on X
Don't you get it?

If lots of people in your population have lower ability to fight infection, it doesn't just mean those people are more likely to *catch* infections.

It means they are more likely to *spread* them too.

Let me explain.
This is important.
Jack has a metal lunchbox.
No ants can get into his lunchbox, so when he leaves the park, no ants fall out of his lunchbox.

Annie has a lunch bag made of wool.
Ants can climb into it, and they can also fall out easily too.
And that's what they do.
Obviously it's more complex than that. But if you don't catch something in the first place then you don't spread it.

But there's much more to it than that.
You can only spread it if you catch it.

And if there's a problem with your body's defences (and the science is now endless that explains how Covid infections damage your body's defences) then you're more likely to catch something.
If you're less able to fight the infection, then you carry the infection for longer, so you may be infectious for longer.

And covid infections make you less able to fight other infections.
And if your body is less able to keep the infection under control, it may be that the infection reproduces in greater quantities, so there's more to infect other people.

And covid infections make your body less able to keep other infections under control.
Now, we know very well now, from repeated studies, that most people are left with a *slight* reduction in ability to fight other infections after they've caught Covid.
So in that circumstance most people are *slightly more likely* to both catch and spread other infections.
But we also know that some people have a significant loss of ability to fight infection after they've caught Covid.
So among the population who are *slightly more likely* to catch and spread something, you also have people who are *much more likely* to catch and spread something, and *much more likely to be seriously ill*.
Or die.
So you get a two layered effect:
Most people being slightly more likely.
Some people being much more likely.
And the cumulative effect of those two layers is *outbreaks*.
And what have we had these last six years?

<Big Outbreaks>
It's like wildfire season:

The trees are more likely to catch.

And then when they do, they burn hotter and are more likely to spread the fire.

And they are more likely to be completely destroyed.
Fortunately people's bodies still retain a strong ability to build at least short lasting immunity to those infections that have flown round.

So in the last five years we have had massive serious outbreaks of
Strep A
Whooping Cough
Mycoplasma pneumoniae
But we've also had a load of serious smaller outbreaks on local levels.

Think of the cryptosporidia, clostridium, shigella, lambia, salmonella, E Coli, klebsiella, campylobacter, legionella, pseudomonas, and others increases.
Because everyone only needs to be slightly more likely to catch and spread stuff for a lot more people to catch and spread stuff.
And so you get the BBC trying to wrap their heads around situations like this: Image
The meningitis outbreak only defies explanation if you refuse to accept that covid infections make you more vulnerable to other infections.
And there's an extra bonus too.

People often carry meningitis bacteria around harmlessly in their nose and throat without developing the full blown illness that happens when it gets into your blood or brain.
But Covid infections can both damage the tissue of your nose and throat to allow access... but also make you more prone to *other infections that damage your nose and throat* to amplify the chance of bacteria being able to get through.
And covid infections also damage the blood brain barrier too, so there's that.
And every covid infection *adds* to the risk.

So the more covid infections people have, the more vulnerable our population will be to these outbreaks.

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More from @1goodtern

May 14
I don't think I have ever been so appalled about public health policy, information, and communication than by what I'm hearing about hanta at the moment.

It's like people's brains are just switched off.
Like they can't think straight.
It's unbelievable.
I genuinely think we should *not* be at high risk of a universal spread of hantavirus, but we don't need universal spread for it to have been an absolute failure.
If there are a couple more generations of spread, then it risks becoming a nightmare.

Is that going to happen? I don't know.
Neither do you.
The WHO doesn't know.
No one does.
Read 27 tweets
May 9
Since we've decided to do this all again:
🔟
Ten things that can reduce the risk of catching an airborne pathogen:
1 An ffp2+/n95+ mask (respirator) worn properly
2 Ventilation
Read 31 tweets
May 9
People are just not going to be able to get their heads round the slow incubation period of hantavirus.

On reflection, thousands of people have probably already been exposed, and those thousands could expose tens, even hundreds, of thousands more.
The sheer time scale is almost impossible to grasp when placed in the context of people engaged in the kind of fast international travel involved with a cruise ship.
You might think that's ridiculous because a cruise ship is slow and contained, but it's not the cruise ship so much as the interwoven pattern of flights people take to *get to and from* the cruise ship.
Read 23 tweets
May 8
I'm just going to say it again once, as simply as I can, for everyone who is slow to understand this:

Covid infection damages the vascular endothelium, the delicate lining inside your blood vessels.

Hantavirus *targets* the vascular endothelium.
If you've had the first one, you're more likely to be susceptible to, and damaged by, the second.
I don't know how to explain it more simply.
Read 9 tweets
May 5
I don't think Covid infections cause hantavirus infections, obviously. Who would?

But guess what:
Once you've had Covid, you're going to be more vulnerable to hantavirus, and then possibly increasingly with each extra infection.
Why?
Let me explain:
Andes hantavirus is not really a 'disease of the lungs' disease in the simple sense people imagine. A huge part of the danger comes from what happens to the lining of the blood vessels, especially in the lungs.
The blood vessels become leaky, fluid ends up where it should not be, oxygen exchange starts failing.
Platelets get consumed.
Blood pressure collapses.
It is, basically, a vascular and immune regulation problem.

Sound familiar?
Read 62 tweets
Apr 28
Covid cases, positivity, hospitalisations, and wastewater here in the UK are all at their lowest point since surveillance started.

Here are the ten things I'm doing differently:
1
I'm still masking with an ffp3 mask everywhere indoors in public to avoid inhaling viral particles.
2
I'm still using hepa filtration in my workplace to filter viral particles out of the air.
Read 14 tweets

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