Although this survey based study suggests some improvement over time, the burden of long COVID remains high, with millions of adults still affected and true biological recovery remaining uncertainđź§µ
This study analyzed data from the US National Health Interview Survey from 2022 to 2024 to examine how common long COVID is and how often people report recovering from it.
The main findings.
From 2022 to 2024, the share of US adults who reported ever having had COVID increased from 39.6% to 60.4%. Among those individuals, however, the proportion who reported ever having long COVID fell from 19.7% to 13.7%.
At the same time, the proportion who reported recovery from long COVID increased from 51.2% to 59.7%. In 2024, the authors estimated that 8.3% of all U.S. adults had experienced long COVID at some point.
Higher LC likelihood was consistently associated with being female, being between 35 and 64 years old, and having lower household income.
Non-Hispanic Asian adults showed a lower likelihood. Long COVID was more common among people living outside metropolitan areas and in certain U.S. regions.
When it came to recovery, the clearest pattern was that adults aged 35 and older were less likely to report recovery.
Many people, especially those over 35, continue to experience persistent symptoms. The study also highlights the need for a better understanding of the biological mechanisms behind long COVID, especially since there is still no clearly proven effective treatment.
The data are based on self report, which means there may be inaccuracies or misclassification. It also does not follow the same individuals over time. Instead, it compares different population samples across different years. As a result, it cannot show true individual recovery trajectories.
Most importantly, this paper does not demonstrate true biological recovery. It only captures self-reported disappearance of symptoms in a survey setting.
The authors defined recovery in a simple way - a person had previously reported long COVID, but later answered that they no longer had symptoms. That may be useful for population-level analysis, but it is not the same as objectively confirmed recovery.
After SARS-CoV-2 infection, the risk of later EBV mononucleosis was higher than in people without recorded COVID-19.
A study based on nationwide Swedish registries followed nearly 10 million peopleđź§µ
10 mio people aged 3-100 years from January 1, 2020, to November 30, 2022.
The authors divided participants into those without a COVID-19 diagnosis, those with a positive PCR test without hospitalization, and those hospitalized with COVID-19.
Main finding?
After SARS2 infection, the risk of later EBV mononucleosis was higher than in people without recorded COVID-19. Among individuals with a positive PCR test who were not hospitalized, the adjusted relative risk was about 1.6 times higher, and among those hospitalized with COVID-19 it was about 5.7 times higher.
For many people, COVID did not end when the infection cleared - it evolved into a longer and far more complicated story.
This paper presents Long COVID as a heterogeneous, multisystem condition that can affect nearly every organ systemđź§µ
This paper is a broad, wide ranging review of Long Covid. @elisaperego78 describes Long COVID as a heterogeneous, multisystem disease that can affect almost the entire body, with effects ranging from subtle or barely noticeable changes to severe disability or even death.
A key point throughout the paper is that this is not just fatigue after a viral illness, but a condition associated with measurable biological abnormalities.
In this cohort of healthcare workers infected with the original SARS2 variant, symptoms were still present even after a median of 47.5 months (!).
Brain fog may persist.
This is a prospective multicenter cohort study from Switzerlandđź§µ
The study was designed in a fairly sensible way. The authors did not automatically treat every complaint as long COVID, but instead compared 24 chronic symptoms between the previously infected group and an uninfected control.
In this way, they identified 13 symptoms that occurred more frequently after prior infection. The most common were fatigue, smell/taste disturbance, so-called brain fog, meaning problems with concentration and cognition.
An interesting and biologically plausible pilot study that provides a fairly strong signal that pediatric Long COVID may be associated with impaired microcirculation and increased arterial stiffnessđź§µ
The study builds on earlier adult research suggesting that persistent symptoms after COVID may be linked to capillary loss and endothelial dysfunction.
This was an observational comparative cohort study, not a randomized or interventional trial.
The study included 37 pediatric patients with Long COVID and 46 healthy controls. On average, the patients were evaluated about 206 ± 167 days after a positive test, so often many months after the initial infection.
The study supports concern that long COVID may be associated with an increased risk of mild cognitive impairment, including impairment with features resembling early Alzheimer’s disease🧵
The study examined whether people with long COVID have a higher incidence of mild cognitive impairment (MCI) than people who had COVID without persistent symptoms and than COVID negative controls.
The authors evaluated 260 individuals and used standardized neurological and neuropsychological assessments, with blinded diagnostic evaluation.
A new long COVID paper suggests that, in a subset of patients, the picture may involve circulating microaggregates, impaired capillary flow, and - EBV-related immune activationđź§µ
A study describes a subgroup of patients who had so called microaggregates in blood, along with stronger T-cell responses to EBV.
The main idea is that, in some patients, long COVID may involve a mix of impaired microcirculation and immune activation linked to latent herpesviruses.
So what are these microaggregates?
The authors describe them as spherical structures around 100-200µm diameter, containing leukocytes and an amorphous core rich in carbohydrate residues. Platelets were also found on their surface.