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Zdenek Vrozina Profile picture
Zdenek Vrozina
@ZdenekVrozina
Health Care Consulting
12 subscribers
Oct 11 • 24 tweets • 4 min read
New preprint from Harvard & Massachusetts General Hospital -children with Long COVID show markedly increased levels of fibrinaloid microclots in their blood!
The highest levels appear in those with persistent SARS-CoV-2 spike protein in circulation🧵 Long COVID affects roughly 1 in 5 children after SARS-CoV-2 infection.
Common symptoms include fatigue, brain fog, pain, and shortness of breath.
Diagnosis remains largely clinical - we still lack objective lab biomarkers for pediatric LC.
Oct 11 • 11 tweets • 2 min read
The study, conducted in a mouse model, shows that SARS-CoV-2 infection can alter epigenetic information in sperm - specifically the profile of small noncoding RNAs passed on at fertilization - and that these changes can be transmitted to the offspring🧵 These changes may influence the development of the nervous system and the stress response of the offspring, independently of the DNA sequence itself.
Oct 10 • 12 tweets • 2 min read
COVID didn’t end - it changed the baseline of how often people fall ill, miss work, and drop out of the labor force. A new JAMA study shows the US now lives in a permanent flu-season mode, all year round🧵 COVID-19 has created a new year-round baseline of illness - its effects persist even without major waves or restrictions, pointing to chronic impacts from ongoing infection or post-infectious conditions, including long COVID.
Oct 10 • 16 tweets • 3 min read
Post-COVID depression isn’t weakness.
It’s biology.
A landmark, important study shows how the virus leaves a measurable molecular trace - in the very proteins that protect your brain from degeneration🧵 A new study in Translational Psychiatry shows that psychiatric symptoms after COVID-19 aren’t just psychological.
They have a biological signature - measurable changes in blood proteins linked to the brain, metabolism, and immunity.
Oct 9 • 14 tweets • 3 min read
7-12% of patients recovering from moderate to severe COVID-19 show persistently low counts of B cells, CD4 T cells, and Tregs, even after clinical recovery.🧵 This sustained adaptive immune deficit may represent a important mechanism underlying Long COVID, resembling immunological patterns seen in chronic infections such as HIV and EBV.
Oct 9 • 19 tweets • 3 min read
Yes, we wrote about this study. It is important.
A study from Cambridge in Brain shows that even months after COVID-19, survivors still carry measurable inflammation-related changes in the brainstem - the part of the brain that keeps you breathing, awake, and alive🧵 Using ultra–high-field 7 Tesla MRI, researchers found abnormal magnetic signals (quantitative susceptibility mapping, QSM) in key brainstem areas.
medulla oblongata
pons
especially in the raphe nuclei and reticular formation - core hubs for breathing and autonomic control.
Oct 7 • 14 tweets • 3 min read
SARS-CoV-2 can create an oncogenic-like cellular environment - switching off tumor suppressors, activating growth pathways, reshaping epigenetic control, and fueling inflammatory metabolism.
If these effects persist, the virus could act as a cofactor in carcinogenesis🧵 The authors don’t claim SARS-CoV-2 causes cancer like HPV or EBV.
They show that the virus interferes with the same cellular checkpoints and signaling pathways commonly disrupted in tumors.
It’s about strong oncogenic potential, not direct oncogenicity.
Oct 7 • 12 tweets • 2 min read
Your nerves remember COVID.
A new study shows the virus can leave a measurable scar in your muscles - electrical, structural, and lasting for over a year.🧵 Researchers followed 70 people - after mild and severe COVID - for 12 months.
They focused on two key lower-leg muscles-
tibialis anterior (lifts the foot)
gastrocnemius lateralis (part of the calf).
Oct 5 • 25 tweets • 3 min read
COVID was never just a respiratory virus - it’s a systemic one.
A pathogen that rewires immunity, disrupts mitochondria, and infiltrates the nervous system -
sharing striking parallels with HIV.
Here’s part of what we already know🧵 Different viruses, same strategy -
silence interferon
erase MHC-I visibility
crash mitochondria
hijack calcium signaling
The goal? Evade, persist, and reshape the host from within.
Oct 1 • 17 tweets • 3 min read
COVID and brain fog.
For millions, it’s the most disabling legacy of the pandemic.
Now, a new brain imaging study reveals a clear biological basis - and the parallels with other diseases are not encouraging.🧵 Researchers used PET scans with a tracer ([11C]K-2) that binds to AMPA receptors - the tiny gates that neurons use to fire signals via glutamate, the brain’s main excitatory messenger.
These receptors are crucial for learning, memory, and attention.
Oct 1 • 13 tweets • 3 min read
This is the strongest evidence yet that ignoring the chronic impacts of COVID in children carries population-level consequences.
A massive Lancet Infect Dis study of >465,000 kids shows:
Reinfections double the risk of long COVID.🧵 After the first infection: about 903 cases of long COVID per million children (within 6 months).
After the second infection: ~1884 cases per million.
That’s more than double the risk (RR = 2.08).
Sep 30 • 13 tweets • 3 min read
This preprint shows how SARS-CoV-2 acts like a biological hacker - taking over our protein factories and silencing immune defenses.
It’s not just a respiratory infection. The virus reprograms the fundamental machinery of the cell - and that’s why its impact can linger.🧵 Remember when we learned Nsp1 alone could sabotage ribosomes? Yerlici et al., 2024.
The new preprint reveals SARS-CoV-2 goes even further - broadly reprograms translation to favor viral RNAs + silences immunity.
Sep 29 • 13 tweets • 2 min read
New peer-reviewed study on the chronicity of COVID-19 in Viruses.
One of the authors? Former CDC director Robert Redfield.
The paper warns about persistence of SARS-CoV-2 in Long COVID - and doesn’t shy away from controversy.🧵 LC (PASC) = debilitating chronic disease.
10–20M in the US, >420M globally
200 symptoms, hitting 12 organ systems
No approved treatments
Affects kids, adolescents, healthy adults
Sep 27 • 12 tweets • 2 min read
A study just tested whether an old HIV drug - tenofovir (TDF/TAF) - could work against SARS-CoV-2 and even help with long COVID.
The lab results are striking: it strongly blocked the virus🧵 Tenofovir is a nucleotide analog - a fake building block for viral RNA.
Once inserted, it stops the virus from copying itself.
In experiments, this worked even at high viral loads.
Sep 26 • 12 tweets • 2 min read
A new 3-year follow-up study in Brain Communications tracked patients with post-COVID brain condition for 38 months.
What they found is a story of part compensation, part healing in the brain.🧵 At 6 months, people with post-COVID were still very tired.
Thinking was mostly fine, but attention and alertness were weaker.
Brain scans showed the frontal lobes working overtime - the brain was pushing harder to keep up. That’s early compensation.
Sep 25 • 12 tweets • 2 min read
One mystery of Long COVID - why immune cells get stuck in a harmful, inflammatory mode.
A new study shows the switch is metabolic - and a single checkpoint can decide whether Th17 cells protect or drive disease.🧵 In both children and adults with Long COVID, we see immune cells stuck in a harmful mode.
Among them - Th17 cells, which can either protect us or drive chronic inflammation.
A new study in Science Signaling, 2025 uncovers why these cells flip - and what keeps them locked in the pathogenic state.
Sep 24 • 15 tweets • 2 min read
A massive new peer-reviewed review (161 studies, 2+ million patients) makes it clear.
COVID-19 isn’t just a respiratory infection.
It’s a multi-system disease leaving lasting scars on lungs, heart, brain, kidneys, and more.🧵 Among hospitalized patients the numbers are stark.
Lungs - 78% affected
Heart - 32%
Nervous system - 43%
Kidneys - 28%
Months later, 10-35% still live with organ dysfunction.
Sep 24 • 17 tweets • 3 min read
“Up to 5 million people worldwide may be walking around with hidden heart damage after COVID - their hearts silently struggling months or even years later.”
Estimate from the European Society of Cardiology (2025).
The first spotlight.🧵 Europe’s leading cardiology authority has issued official guidance on COVID’s cardiovascular impact.
Published in the European Journal of Preventive Cardiology.
This is the real manual for what to do - a long-awaited step that gives hope change is possible.
Sep 23 • 17 tweets • 3 min read
Children after mild or ordinary COVID-19 show measurable brain changes. Some improve, others persist.
This is a peer-reviewed MRI study in Brain and Behavior, 2025.
MRI data in children are still scarce - every study counts.🧵 Importantly, all cases were mild-to-moderate - no severe illness - yet measurable brain changes were still detected.
Sep 22 • 15 tweets • 3 min read
Children don’t just bounce back after COVID.
A Bavarian study shows deep neurocognitive and emotional impacts in kids & teens - fatigue, loss of motivation, attention problems, mood disorders.
What they found🧵 85 children, ages 2-17 (avg 12.5, 61% girls). All had confirmed COVID and symptoms lasting ≥4 weeks.
They underwent multidisciplinary exams - psychiatry, neurology, cardiology, pulmonology, gastro + neuropsychological testing.
Sep 19 • 17 tweets • 3 min read
SARS-CoV-2 can turn our own defenders into traitors.
A study in Sci Transl Med, 2025 shows the virus drives neutrophils into PMN-MDSCs cells that don’t fight, but suppress T cells.🧵 Instead of attacking the virus, these neutrophils hit the brakes on adaptive immunity.
T cells divide less, signal less.
The immune response collapses from within - right when it should be gaining strength.