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Putrino Lab Profile picture
@PutrinoLab
Mar 25 • 8 tweets • 2 min read • Read on X
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I want to thank everyone for the interest in this work that we completed in a #LongCOVID cohort with this novel device. I always appreciate feedback and want to thank folks for holding me accountable to a high standard of communication. To that end, I want to re-clarify this
1/
thread: this was a safety/feasibility trial which means that our primary endpoints were related to safety and feasibility. In the paper, we state clearly that we hit those endpoints: no device-related adverse events and 100% adherence to the protocol in all participants. That
2/
is great for a safety/feasibility trial. I then went on to express excitement that some cognitive scores moved. I understand that folks have (rightly) pointed out that without a larger sample size and correcting for multiple comparisons we can’t make definitive statements
3/
about efficacy. This is correct. As I pointed out in the original thread, we will be getting a multisite pivotal trial to prove or disprove efficacy off the ground shortly. I apologize if my enthusiasm for observed mobility in the cognitive scores overshadowed the stated need
4/
for a larger pivotal. The larger pivotal is the crucial next step. In addition, as is our way with all research at our center, we are delving into biomarker analysis to better understand if correlations exist between blood biomarkers and cognitive outcomes in this cohort. Most
5/
importantly: enthusiasm should not ever trump rigor as we carefully, yet urgently pursue actionable treatments for people with #LongCOVID and other infection-associated chronic conditions and illnesses such as #MECFS and chronic tick- and vector-borne illness. We don’t take
6/
the trust of this community lightly, but we also want to share meaningful data rapidly. I remain highly enthusiastic about these pilot data and believe that they strongly support progression to a larger pivotal trial to explore efficacy, which is exactly the plan. Thanks as

7/
always to this great and rigorous community. 🙏🏻

/end

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More from @PutrinoLab

Putrino Lab Profile picture
Mar 24
Excited to get this out in preprint: triple-blind, placebo-controlled microtesla magnetic therapy (MMT) is safe, feasible and effective in reducing cognitive impairment in people with #LongCOVID. I get excited about interventions for cognitive symptoms

1/medrxiv.org/content/10.648…
as they can be so disabling and frightening because you don't know if the symptoms are going to be permanent. This paper makes us feel hopeful that Long COVID cognitive impairment related to neuroinflammation is something that is treatable. This was a first-in-human safety-
2/
feasibility trial. Typically in trials like this, because they haven't been done in humans and only in animals, we're happy if we see safety and good adherence to the protocol, but we're not usually expecting to see efficacy because the dosage is a bit of a "best guess".
3/
Read 10 tweets
Putrino Lab Profile picture
Mar 13
Proud to have worked with the brilliant @drmfreire on this new study looking into spike protein in #LongCOVID. The most important part of this study that doesn't just look for spike protein in folks with LC and healthy controls, but it also uses a technique called
1/
spatial transcriptomics to better understand how spike protein might be interacting with the tissue around it. Here's what is interesting about this trial: lots of gut tissue samples, in both healthy controls and #LongCOVID showed evidence of persistent spike protein. However,
2/
in the folks with #LongCOVID that persistent spike protein was causing problems in the tissue: pro-inflammatory, tissue-damaging trouble. So not only do folks with LC have more spike, but the spike is actively irritating and damaging the surrounding tissue compared to healthy
3/
Read 7 tweets
Putrino Lab Profile picture
Feb 17
Crucial paper published Friday that deserves much more attention in the #LongCOVID world: .

TLDR: 13/15 immunocompromised patients who had chronic COVID infections (>200 days) cleared the virus in under 2 weeks when given combo antivirals/monoclonals

1/nature.com/articles/s4159…
The caveat: yes these were cancer patients who were severely immunocompromised, and the "haters" are going to say that it isn't appropriate to draw parallels between this patient group and folks with #LongCOVID.

That's incorrect.

It is perfectly acceptable to draw such

2/
parallels and here is why: we (and others) have shown over and over again that immune dysregulation is associated with #LongCOVID, and T Cell Exhaustion, specifically, is a key feature of this dysregulation (first paper here: ). Why is T Cell exhaustion
3/nature.com/articles/s4158…
Read 9 tweets
Putrino Lab Profile picture
Jan 5
Great win early in the year to receive notification that our case series looking into Dr Pridgen’s Valacyclovir, Celecoxib and Paxlovid protocol seems to really help some folks with #LongCOVID. This paper is a start, not the be-all and end-all:


1/frontiersin.org/journals/immun…
It is a small, open-label case series, but there are some interesting things that are worth noting that give me hope that what we are seeing is real and will hold up in a larger trial
1) People got to choose between Val/Cel only (called ‘IMC-2’ in the paper) and Val/Cel + Pax
2/
The people who chose the latter reported greater benefit. 2) The subset of people who started with Val/Cel only but then chose to retry the protocol with Paxlovid added experienced more benefit with the three drugs together than they did with the two drugs
3) The follow-up
3/
Read 6 tweets
Putrino Lab Profile picture
Jan 1
Wishing everyone a happy new year and we will be forging ahead in 2026 with renewed energy to find answers for people living with #LongCOVID, #MECFS, chronic #lyme and other infection-associated chronic conditions and illnesses. Speaking for myself, here are some questions I
1/
hope we can answer this year. Since it isn’t my first time on the internet let me explicitly state: there are other questions that we will be chasing equally aggressively, but these are the ones that I most want to answer to up-level my own understanding of the scientific and
2/
clinical problems that we face.
1) Why do some people test positive on certain persistence assays and negative on others? How can we use all of the commercially and scientifically available assays to create a unifying test for persistence that helps us to understand when and
3/
Read 10 tweets
Putrino Lab Profile picture
Dec 29, 2025
Respectfully @jonstewart, you were wrong on the @weeklyshowpod to mock people who mask. ICYMI: there are tens of millions of Americans who have been disabled by #LongCOVID and must do everything in their power to prevent further infections that make them vulnerable to further
1/
worsening of their symptoms. There are countless millions more who are immunocompromised or love someone who is and must therefore mask to protect themselves from a virus that continues to spread without mitigation due to its novel ability amongst viruses to persist in the
2/
body and drive immune dysregulation, hypercoagulation, oncogenic processes, nervous system dysfunction, cognitive decline and other terrible long-term effects. Furthermore, after hearing all the things that this virus drives, there are those of us who are perfectly healthy who
3/
Read 9 tweets

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