Dalton (Analyze & Optimize) Profile picture
Apr 2 9 tweets 4 min read Read on X
You can literally clean out your brain doing this.

The GLYMPHATIC SYSTEM in the brain helps flush out various toxins from the cerebrospinal & interstitial fluids of the brain.

It might just be your behind fatigue, cognitive decline and even depression.

Here's how (🧵1/8):
The brain produces cerebrospinal fluid from blood for a multitude of reasons.

Your neurons need it to fire properly, and it also physically protects your brain from damage and from being too heavy.

But perhaps the most important role of CSF is to enable glymphatic clearance. Image
The body had the lymphatic system.

Your tissues get blood for nutrients, and they produce waste, which gets taken up by lymphatic vessels.

These drain into your lymph nodes where your immune cells can clean up various toxins, microbes, or other byproducts.

The thing is, the lymphatic system does not have a heart equivalent constantly pumping it around, so it can become stagnant if we do not manually mobilize it.

The same is true in the brain.Image
Cerebrospinal fluid exchanges into the brain tissue and collects waste.

This waste gets dumped into the venous region, where it ends up getting cleared into the outside of the brain (meninges).

From there it gets cleared into the lymph nodes of the neck.

So long story short, it has a lot of traveling to do and it needs help getting there.Image
As it turns out not clearing out this waste from the brain isn't too good for it.

Recent studies have shown that dysfunction of the glymphatic system is prevalent in depression.

They had poorer glymphatic clearance out of the brain than non-depressed individuals. Image
Glymphatic dysfunction can also contribute to chronic fatigue.

If you're not clearing out this waste from the brain:

◇ Oxidative stress ensues
◇ Mitochondria become dysfunctional
◇ The blood brain barrier becomes impaired
◇ The brain becomes inflamed

All key in cases of fatigue.Image
Draining the glymphatic system treats Alzheimer's.

Multiple animal studies have shown this improves outcomes, and now we even have some human evidence.

Amazing what happens when you focus on this. Image
I've covered many of the techniques to help optimize glymphatic clearance here:
If you want to get some personalized help from us with ANY of your health goals, we’re taking clients virtually worldwide every day at PRISM. Book a free call here for more: go.prism.miami/consultation

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More from @Outdoctrination

Mar 29
If you CAN'T SLEEP, read this. Here are 6 KEYS to focus on you've been ignoring (🧵1/6):

#1 Glycine

Glycine has been shown to:

◇ Help stop nighttime urination
◇ Improve sleep satisfaction
◇ Improve daytime alertness

It acts as a neurotransmitter to promote sleep (NMDA).Image
#2 Undereating

Not saying to stuff your face, but if you undereat on total calories and especially on carbs - this can ruin your sleep by:

➜ Lowering leptin / raising orexin (prevents sleep)
➜ Increasing cortisol and other stress hormones

Ensure you're getting enough. Image
#3 Circadian rhythm

This goes beyond just avoiding screens at night.

Your body wants to have regular eating and sleeping times, to coordinate cellular activity and hormone secretion.

If you don't have this, your body doesn't know when to lower cortisol and raise melatonin for sleep.Image
Read 7 tweets
Mar 29
A groundbreaking new study shows that a mineral deficiency can drive Alzheimer's, and consuming it can reverse it.

(🧵1/10)Image
The study was published last year in Nature.

While lithium is used as a drug in high doses for things like bipolar disorder, it is a naturally occurring mineral in some foods and water supplies.

Unexpectedly, it seems to play a major role in Alzheimer's.

(2/10) Image
They looked at 27 different metals to see if there were any differences in the brain's of Alzheimer's disease.

Surprisingly, only lithium stood out, in two separate cohorts:

⇨ Lower levels in the prefrontal cortex
⇨ Higher levels in amyloid plaques

Thus, less lithium available for functioning brain tissue.

(3/10)Image
Read 11 tweets
Mar 27
Hair loss / male pattern baldness is an inflammatory condition often driven by excess histamine - and antihistamines can regrow hair.

(🧵1/8)Image
This first study that looked at the antihistamine cetirizine for regrowing hair.

This is the same ingredient as Zyrtec allergy pills - just applied topically on the scalp.

They did this for 6 months. Image
After 6 months, the antihistamine substantially improved hair growth.

◈ Total hair density (ΔD / D₀): +1000% improvement
(0.11 vs 0.01)
◈ Vellus density (ΔVD / VD₀): +650% improvement
(0.15 vs 0.02)
◈ Terminal density (ΔTD / TD₀): +500% improvement
(0.18 vs 0.03)
◈ Hair diameter (Δd / d₀): +25% improvement
(0.05 vs 0.04)Image
Image
Read 10 tweets
Mar 27
A recent study showed that patients with a highly lethal cancer had their tumors shrink, with a 100% disease control rate when given a simple mineral.

(🧵1/7)Image
Advanced non-small cell lung cancer is a brutal condition.

Only ~10% of people with it survive past 5 years.

This study sought to uncover the role of selenium in this cancer, and wanted to see if using it as a therapy could help. Image
Selenium levels are low in people with this cancer, and low selenium drives cancer in animals.

They showed that:

➤ Various immune cells were lower in cancer
➤ Selenium in serum was about 1/3 in cancer compared to health
➤ Animals on low selenium diets got cancer at nearly double the rate
➤ Animals with low selenium DIED of cancer at much higher rates
➤ Giving them more selenium in the diet restored their serum levels + immune cells back to healthy levels

So, clearly selenium is playing a central role here.Image
Read 7 tweets
Mar 25
If you want to live longer, read this.

Here are 6 underrated tools that EXTEND LIFESPAN in research (🧵1/8):

#1 Glycine

Glycine increases lifespan by up to ~28% across different organisms.Image
Glycine counteracts the pro-aging effects of excess methionine, a major component of muscle meat.

It's able to do this through the GNMT enzyme - which absorbs extra methyl groups from methionine.

Those extra methyl groups otherwise alter global gene expression, disrupting several health promoting processes.Image
Glycine is in connective tissues from animal foods (bone broth, fish skins, chicken bones, etc.)

It's also dosed at 3-6g as a supplement (a bit higher than this to reflect the lifespan extending effects in animals).

Our affiliate brand:
analyzeandoptimize.io/shop#glycine
Read 9 tweets
Mar 23
CAVITIES - A sign your internal health is deteriorating.

This is how they happen step by step and how to prevent them (🧵1/14):Image
UNDERSTANDING THE TOOTH.

Teeth have multiple layers, with these top 2 being most relevant for cavities.

While we often think of teeth as just these rocks that are in our mouths, they're highly structured living tissues.

1. Enamel

This is the outermost layer of the tooth, where cavities most often hit.

It's made primarily of a mineral known as hydroxyapatite - a complex of calcium, phosphate and some other elements.

We have cells called ameloblasts which regenerate the enamel, but these only present during youth.

BUT this layer can remineralize passively, meaning it can without the need for these cells to a certain degree (more on that later).
2. Dentin
This is the layer right below the enamel, and unlike the enamel this can actively regenerate via cells called the odontoblasts.

However these cells can die off if you aren't careful, especially from bacterial antigens like endotoxin.

3. Pulp

This is the soft tissue containing nerves. If your cavity reaches here, you'll need a root canal or even get a tooth yanked.

The deeper a cavity goes into the tooth, the more it will hurt.

The key to understand here is that remineralization only really happens at the very early stages of the cavity. Once it gets deep enough, you're essentially screwed.

So DON'T WAIT. You want to act preventatively.Image
THE CENTRAL ROLE OF ACIDITY.

This is the structure of hydroxyapatite, which is the crystal that makes up the enamel.

Acidity is an abundance of H+ ions - and these react with the PO4 molecules in the lattice to create hydrogen phosphate.

This causes the entire structure to collapse - and you get a cavity!

Thus, preventing ACIDITY in the mouth is the absolute most important thing.

But what causes acidity?Image
Read 15 tweets

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