Thread by @dbdugger

Ironically, Chertow observed persistence in the basal ganglia of six individuals, the same sitting at the table.

How will the MEntally ill sacrifice them today, LMAO!!!

https://twitter.com/JoannaTeglund/status/2048486085169152322

See? It's always been an unscientific narrative to suggest individuals have developed ME/CFS, hasn't it?
2022 Apr 26
Parkinson’s Disease and SARS-CoV-2 Infection: Particularities of Molecular and Cellular Mechanisms Regarding Pathogenesis and Treatment
pmc.ncbi.nlm.nih.gov/articles/PMC91…

"The most common cause of familial PD dysfunctional autophagy is associated with the expression of dominant mutants of LRRK2 (leucine-rich repeat kinase 2). LRRK2 mutations disrupt both DA neurons as well as the astrocytes."

"LRRK2-mutant dopaminergic neurons have an altered CMA process, leading to abnormal aSyn accumulation, preceding accumulation of LB."

See? It's always been an unscientific narrative, hasn't it?
2022 Mar 21
SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro
pubmed.ncbi.nlm.nih.gov/35328814/

28 June 2023
Dementia with Lewy bodies after COVID-19 infection with catatonia: A case report
onlinelibrary.wiley.com/doi/full/10.10…

We also learned of the productive infection of brain microvascular endothelial cells.

2022 Jun 16
SARS-CoV-2 infection of human brain microvascular endothelial cells leads to inflammatory activation through NF-κB non-canonical pathway and mitochondrial remodeling
pmc.ncbi.nlm.nih.gov/articles/PMC92…

We also learned of the production infection of astrocytes, which contributes to the profoundness of Asymptomatic Neurocognitive Impairment one experience, amyloid deposition, and arrythmias in the HIV+.

2022 Jul 18
In SARS-CoV-2, astrocytes are in it for the long haul
pmc.ncbi.nlm.nih.gov/articles/PMC93…

See? It's always been an unscientific narrative, hasn't it?
2022 Nov 11
SARS-CoV-2-Induced Amyloidgenesis: Not One, but Three Hypotheses for Cerebral COVID-19 Outcomes
pmc.ncbi.nlm.nih.gov/articles/PMC96…

"Amyloid deposition is also found around cerebral blood vessels, termed cerebral amyloid angiopathy (CAA), in 90% of AD cases."

"Although the relationship between these two amyloid disorders is obvious, this does not make CAA a characteristic of AD, as 40% of the non-demented population presents this derangement."

"Several receptors for SAA have been identified, including scavenger-receptor SR-B1 (involved in cholesterol efflux and removal of SAA), toll-like receptors 2 (TLR2) and 4 (TLR4), and receptor for advanced glycated end-products (RAGE) (all enhancing immune activation)."

Akiko Iwasaki told everyone the correct parallel to draw after using HIV's Nef as positive control in April of 2023.
2023 Apr 10
Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants
Akiko Iwasaki
pmc.ncbi.nlm.nih.gov/articles/PMC10…

"We also included HIV Nef as a positive control for downregulating both MHC-I and MHC-II (30, 31), and SARS-CoV ORF8a/b proteins as a negative control."

"We found that in addition to ORF8, SARS-CoV-2 E, M, and ORF7a substantially down-regulated MHC-I within the cells expressing these viral proteins."

We don't know if those six kids have had their p-tau 217 levels assessed. There certainly is a test now available as individuals read of HIV's Nef being referenced in journal articles.

FDA Clears First Blood Test Used in Diagnosing Alzheimer’s Disease
fda.gov/news-events/pr…

"The Lumipulse G pTau217/ß-Amyloid 1-42 Plasma Ratio is for the early detection of amyloid plaques associated with Alzheimer’s disease in adult patients, aged 55 years and older, exhibiting signs and symptoms of the disease."

Five months after she published her paper, we learned of cholesterol efflux pathway impairment.
Published: 28 September 2023
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
nature.com/articles/s4416…

"33. Collins, K. L., Chen, B. K., Kalams, S. A., Walker, B. D. & Baltimore, D. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391, 397–401 (1998)."

How fucking stupid do you have to be?
Abundance of Nef and p-Tau217 in Brains of Individuals Diagnosed with HIV-Associated Neurocognitive Disorders Correlate with Disease Severance
pubmed.ncbi.nlm.nih.gov/34843091/

Long COVID Linked to Alzheimer’s Disease Mechanisms
nyulangone.org/news/long-covi…

"Further, CP size increases tracked with blood levels of proteins known to increase as Alzheimer’s disease worsens, like pTau217, and with others that rise in response to brain injury, like Glial fibrillary acidic protein (GFAP)."

Published: 19 March 2024
COVID-19 related neurological manifestations in Parkinson’s disease: has ferroptosis been a suspect?
nature.com/articles/s4142…

Seven days later, the very protein that contributes to microglial ferroptosis in the HIV+ was named here.
March 26, 2024
SARS-CoV-2 targets ribosomal RNA biogenesis
cell.com/cell-reports/f…

"Finally, the Tat protein of human immunodeficiency virus interacts with FBL and U3 snoRNA, impairing pre-rRNA processing and depleting mature ribosomes."

HIV-1 Tat-mediated microglial ferroptosis involves the miR-204-ACSL4 signaling axis
pubmed.ncbi.nlm.nih.gov/37023693/

See? Genetically predisposed in the same way as the HIV+, am I right?
LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein
pubmed.ncbi.nlm.nih.gov/23190742/