Mark Kaplan Profile picture
Jul 5 4 tweets 2 min read Read on X
I am building new arteries inside my body right now.

Not with surgery. Not with drugs. With exercise.

Your body has a backup system most doctors never tell you about. It is called collateral circulation. When a coronary artery narrows, your body can grow entirely new blood vessels to route blood around the blockage.

Natural bypasses. Built by your own biology. Triggered by movement.
The EXCITE trial. 60 patients with significant coronary artery disease. Randomized. Published in Circulation, 2016.

One group did high-intensity exercise. One group did moderate-intensity exercise. One group was the control.

After just 4 weeks, both exercise groups showed significant improvement in their coronary collateral flow index. The control group did not.

Four weeks. Not four years. Four weeks of consistent exercise and the body started building new pathways around the blockage.

The Cleveland Clinic describes collateral circulation as your body's natural mechanism to provide blood flow to ischemic tissue. Your body senses reduced flow. It calls other blood vessels into action. Exercise accelerates the process.
This is what I think about every single day.

My calcium score is over 1,000. I have old plaque in my arteries. That is the past. I cannot undo it.

But every time I walk. Every time I exercise. Every time I push my heart rate up, my body is responding. Building collateral pathways. Strengthening existing vessels. Creating redundancy in the system.

I am not just maintaining my heart. I am upgrading it. Building a network of backup routes that did not exist 6 years ago.

This is what playing offense looks like. Not waiting for the next scan. Building the architecture that makes the scan less relevant.Image
William Heberden first documented this in the 1700s. A patient with severe angina did daily physical activity for six months. His symptoms nearly disappeared.

300 years later the EXCITE trial proved what Heberden observed. Exercise builds coronary collateral circulation. Your body can grow its way around a blockage.

Your doctor may have told you that heart disease only gets worse. That the plaque only grows. That the best you can hope for is management.

That is not what the science says.

The science says your body is capable of building its own solution. You just have to give it the signal.

Move. Every day. Your arteries are listening.

The truth heals

Founder, HealthTruth

Co-founders:
Dr. Philip Ovadia, MD @ifixhearts
Dr. Aseem Malhotra, MD @DrAseemMalhotra
Dr. Robert Cywes, MD, PhD @carbaddictiondr
Prof. Tim Noakes @ProfTimNoakes

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More from @markkaplan20

Jul 5
I have twelve years of my own blood work. Seven panels. Every result, every flag, in the years before the heart attack that nearly killed me at 52.

My doctor circled one number every single time. LDL cholesterol.

He never said a word about the marker flagged four times on the same pages.

In 1976 a doctor named Broda Barnes called that marker the riddle of heart attacks. Mine was screaming. Nobody was listening.

Let me show you what they saw, what they missed, and what almost killed me.

🧵Image
October 2007. I am 39. A former professional tennis player eating exactly what I was told was healthy. Pasta. Gatorade. Whole grains. Low fat everything.

Total cholesterol: 186. Normal.
Triglycerides: 60. Excellent.
HDL: 59. Good.
LDL: 115. Flagged HIGH.

My doctor circled the LDL. He did not mention one other thing on the page.
Every panel after that told the same story.

August 2008: LDL 122. High.
October 2008: LDL 104. High.
April 2009: LDL 109. High.
September 2009: LDL 111. High.
2012: LDL 111. High.
2013: LDL 102. High.

Seven panels. Seven high flags. A statin recommended at every visit. I refused every time.
Read 18 tweets
Jul 5
Heart disease killed my father's generation.

It nearly killed me.

It will not kill my son.

This is the thread I've been building toward for 6 years.
Heart disease has been the #1 killer in America for over 100 years.

Since 1921.

We've spent trillions. We've prescribed billions of pills. We created an entire industry around lowering one number.

1992: 3 million Americans on statins.
2022: 92 million Americans on statins.

Deaths? Still 700,000 a year.

The system didn't fail because it tried and couldn't.

It failed because it was looking at the wrong thing.Image
Here's why nobody has solved this.

Your cardiologist sees your cholesterol.
Your endocrinologist sees your thyroid.
Your primary care sees your blood pressure.
Your geneticist (if you've ever seen one) sees your APOE status.
Your Oura ring sees your sleep.
Your food diary sees your diet.

None of these systems talk to each other.

Nobody is looking at the whole picture.

Because the whole picture doesn't fit inside a 7-minute appointment.
Read 13 tweets
Jul 5
This is my son David. He's 16. He plays tennis. He wants to earn a scholarship to play in college and maybe one day go pro.

His father was a professional tennis player. His father also had a heart attack at 52.

So David is following his dad's footsteps on the court. But not in the kitchen. He eats meat, eggs, vegetables, butter, olive oil. No processed food. No sugar. No seed oils.

His pediatrician looked at his cholesterol number and told him he has a big problem.

He scared a perfectly healthy 16 year old athlete into thinking something is wrong with him.

Nothing is wrong with him.Image
My son watched his father survive a heart attack and change everything. He saw me go from the standard American diet to real food. From statins to zero drugs. From metabolically sick to a metabolic age of 43 at 58 years old.

David made the choice to eat this way because he knows what's at stake. He's doing everything right. Training every day. Eating better than 99% of adults in this country. Zero metabolic dysfunction. Zero inflammation. Zero insulin resistance.

And his doctor looked at one number on a lab report and told him he has a problem.

Not "your father had a heart attack and you're already ahead of it." Not "this is exactly what prevention looks like."

"You have a problem."

That's how it starts. You scare the kid first. The prescription comes later.
Here's what the system tells kids to eat to "keep their cholesterol low."

Whole grain cereal. Low fat milk. Orange juice. Whole wheat bread. Pasta. Rice. Fruit juice.

Sounds healthy right? That's what the guidelines say. That's what the school cafeteria serves. That's what every pediatrician's handout recommends.

Every single one of those foods spikes your blood sugar and drives insulin resistance. The exact metabolic dysfunction that leads to diabetes, obesity, and heart disease.
Read 19 tweets
Jul 5
There are tribes on this planet who eat meat, fat, and whole foods every single day.

They've been doing it for tens of thousands of years.

They don't get heart disease. They don't get diabetes. They don't get obese.

You've been told the food they eat is killing you.

They're the proof it isn't. 🧵Image
I grew up in Johannesburg, South Africa.

I saw it with my own eyes.

Tribes eating meat, organs, animal fat, whole foods straight from the land. Strong. Lean. No hospitals. No pills.

Then processed food arrived. Seed oils. Margarine. Coca-Cola. White bread.

And I watched the healthiest people I'd ever seen start getting sick.Image
The Maasai have eaten meat, blood, and milk for thousands of years.

Their cholesterol would put any American on statins tomorrow.

But when researchers studied them — almost no heart disease.

Mann et al., Journal of Atherosclerosis Research, 1964.

They didn't need a doctor to tell them what to eat. They already knew.Image
Read 15 tweets
Jul 5
One of the biggest cons in the food industry is convincing you that vegetable oil is healthy. Because it has the word vegetable in it.

I want you to look at this chart.

Three lines. Same timeline. Same curve.

Seed oil consumption. Up 820%.
Diabetes. Up 700%.
Obesity. Up 223%.

They all move together. Because they are all caused by the same thing.

There are no vegetables in vegetable oil. Zero. Not one. It is made from seeds. Pressed and processed with petroleum solvents, industrial acid, and bleaching agents until it becomes something a human can swallow.

And it is in everything you eat.

🧵Image
Seed oils are primarily composed of linoleic acid. An omega-6 fatty acid.

Your body needs small amounts of omega-6. But the ratio matters. For most of human history, the omega-6 to omega-3 ratio was roughly 1 to 1.

Today it is 25 to 1.

Look at the chart. The red line left the optimal zone decades ago and never came back.

Excess omega-6 drives chronic inflammation. Inflammation damages arterial walls. Inflammation drives insulin resistance. The Women's Health Study ranked inflammation at 2.98x. More than double the risk of LDL cholesterol.

Seed oils are one of the primary drivers of the inflammation that is killing us.Image
So seed oils drive omega-6. Omega-6 drives inflammation. But does inflammation actually cause heart disease?

The Women's Health Study. 27,939 women. 21 years. JAMA Cardiology. They ranked every cardiovascular risk factor.

hs-CRP (inflammation): 2.98x your risk. More than double the risk of LDL cholesterol at 1.4x.

Then in 2008, the JUPITER trial. 17,802 patients. Harvard. Published in the New England Journal of Medicine. People with normal LDL but elevated CRP had 2.8x higher cardiovascular risk. Their cholesterol was fine. Their inflammation was killing them.

2017. The CANTOS trial. Reducing inflammation alone, without touching cholesterol, reduced heart attacks by 15%.

Inflammation is not a theory. It is the proven mechanism. And seed oils are one of the primary drivers of it.

The oil they told you was heart healthy is driving the inflammation that causes heart disease.Image
Read 17 tweets
Jul 4
Why do 700,000 Americans die of heart disease every year while swallowing 200 million statins?

I was almost one of them.

Heart attack at 52. Seven blood panels. Twelve years of missed signals.

Because we're fighting the wrong fight.

Heart disease isn't ONE problem. It's twelve.

Your doctor tests two.

Here's the 12-headed dragon we're not talking about.Image
Look at this chart.

1992: 3 million Americans on statins.
2022: 92 million Americans on statins.

A 30x increase.

Heart disease deaths? Still 700,000 a year. Still the #1 killer. For over 100 years.

If statins were the answer, the line should be going down.

It's not. Image
We didn't have a cholesterol problem.

We had a 12-headed dragon problem.

The 12 causes of heart disease most doctors don't check:

1. Insulin resistance
2. Chronic inflammation
3. Thyroid function
4. Gut health
5. Sleep quality
6. Chronic stress
7. Seed oils & processed food
8. Refined sugar
9. Physical activity
10. Nutrient deficiencies
11. Alcohol & toxins
12. Diet matched to your DNA

Twelve levers. Your doctor pulls one.Image
Read 8 tweets

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