Jake Gilman Profile picture
Jul 28 13 tweets 3 min read Read on X
Running out of this one molecule ages you faster than smoking.

That's based on a decade of research from Baylor College of Medicine.

Adults over 70 who restored it saw muscle loss, brain fog, and slow healing reverse.

Here's the molecule, and how they did it: 🧵
Inside every cell, glutathione acts like a fire extinguisher, putting out damage before it piles up.

The problem: your body makes less of it every year after 20.

By your 60s and 70s, most people are running on fumes right when the fires start showing up everywhere.
Low glutathione has been linked to nearly everything doctors call "aging": oxidative stress, chronic inflammation, insulin resistance, DNA damage, and muscle wasting.

Once it runs low, cells across your whole body stop protecting and repairing themselves properly.
A team at Baylor College of Medicine tested a fix.

Adults aged 70-80 took two amino acids for 24 weeks.

The findings: glutathione rose back toward levels you'd expect in someone decades younger.
They ran it again, but this time took the amino acids away for 12 weeks after the 24-week course.

The benefits started reversing.

This isn't a one-time fix, it's more like refilling a tank that drains again the moment you stop.

Next question: does this actually change how people function, or just their bloodwork?
In the same trial, muscle strength went up. Gait speed picked up. Insulin resistance dropped. Memory scores improved.

Multiple systems moving at once, not just one number on a chart.

The fix comes down to two amino acids:

Glycine and NAC.
Your body uses both as raw material to build glutathione.

After 20, you can't make enough of either on your own, so the factory runs short no matter how healthy you otherwise are.

Glutathione doesn't stop at aging markers in humans.
A follow-up study gave the same combo to aging mice for life. The ones getting it lived 24% longer than the ones that didn't.

But not all glycine and NAC products are equal.

NAC has had supply issues in recent years after a brief FDA dispute pulled some brands off shelves.
If you want the combination referenced in this research, here's the one to check out (aff link):
amazon.com/dp/B0FW18R82G?…
It's also worth protecting the glutathione you already have.

Poor sleep, chronic stress, and heavy alcohol use all burn through it faster, so the supplement works best alongside those basics, not instead of them.
The data so far is one lab's pilot trials, not yet a massive multi-center study.

But the mechanism, glutathione decline driving multiple aging pathways, is well established.

If you've tried glycine + NAC, what did you notice?
Full study here:
bcm.edu/news/glynac-su…
I hope you've enjoyed this thread!

(And maybe even learned something)

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More from @jakeglmn

Jul 19
Tim Ferriss had the world's leading expert on longevity & brain aging on his podcast.

Dr. Rhonda Patrick.

She revealed the overlooked science behind brain health that most doctors won't tell you...

My top 6 takeaways:

1. 5g of creatine daily does almost nothing for your brain
2. Saunas 4-7x per week

Cut Alzheimer's risk by 65%.

A 20-year study of 2,000 men proved it.

Just make sure you're not using it above 190 degrees:
3. Omega-3s probably aren't reaching your brain

Most people take fish oil daily and get almost zero brain benefit.

Standard capsules deliver omega-3s in the wrong form for your brain to absorb.

And if you have a common genetic variant, it's even worse:
Read 8 tweets
Jul 18
Your body is quietly on fire.

It's called "inflammaging".

Low-grade inflammation that drives Alzheimer's, diabetes, heart disease, cancer, and arthritis all at once.

Here are the 6 best ways to put it out:
Inflammaging = the chronic, low-grade inflammation that builds as your body ages.

Your immune system slowly loses its ability to clean up damaged cells.

Those damaged cells pile up and never stop releasing inflammatory signals that silently drive disease.
Scientists call these "zombie cells."

They can't function properly, they refuse to die, and they keep sending out distress signals that trigger inflammation throughout your entire body.
Read 13 tweets
Jul 16
Scientists gave 200 married couples a voodoo doll of their spouse.

They were told to add a pin every time their spouse annoyed them.

After 6 weeks, one measurement predicted who stabbed it the most.

And it had nothing to do with their relationship... (thread):
The study began as an experiment on food.

Researchers wanted to understand what happens inside your body every time you eat.

So they tracked 200 couples over 6 weeks measuring one single metric around the clock.

What they found went far beyond food:
The metric was blood sugar.

Specifically, glucose spikes: the rapid rise and fall of sugar in your bloodstream after eating.

Researchers expected to find links to energy levels, weight, maybe fatigue.

They were completely unprepared for what else it predicted:
Read 13 tweets
Jul 2
There's a parasite spreading across the United States causing "explosive" diarrhea that can last 6 weeks straight.

It's confirmed in 17 states and hundreds of cases have been reported.

Here's what it is, and how to actually protect yourself: 🧵
Image
What it is?

Cyclospora cayetanensis is a microscopic parasite you can't see, smell, or taste.

You catch it by eating fresh produce contaminated with tiny traces of infected feces. Image
The symptoms are brutal...

Watery, frequent, sometimes "explosive" diarrhea. Plus cramps, nausea, bloating, fatigue, and no appetite.

Left untreated it can last up to 6 weeks and come back in waves.
Read 13 tweets
Jun 28
Over 20,000 studies prove TURMERIC is the most powerful anti-inflammatory on Earth.

It destroys chronic pain, flushes toxins from your liver, and protects your brain from early aging.

Here's everything you need to know about it:

1) It heals your gut first
Most people think turmeric works by entering your bloodstream.

It doesn't.

Only 1-2% gets absorbed. The real magic happens in your gut where turmeric feeds healthy bacteria and stops inflammation before it spreads.

Here's why that matters:
Inflammation doesn't start in your joints, your brain, or your heart. It starts in your gut and slowly spreads everywhere else.

Turmeric works differently than any painkiller or supplement you've tried. Instead of masking the pain, it attacks the source.
Read 11 tweets
Jun 27
A 2-year trial just tested whether you can actually slow human aging.

And it worked better than anyone expected.

Two supplements helped cut invasive cancer 61% and frailty 40% in older adults, and slowed aging in their actual DNA (for under $1 a day).

Here's what happened:🧵
We measure biological age with "epigenetic clocks".

DNA patterns that shift with age and predict disease and death better than the number on your license.

These clocks (DNA GrimAge & PhenoAge built by Dr. Steve Horvath at UCLA) are scary accurate.
GrimAge basically estimates your time to death.

The faster your clock ticks, the faster you're aging.

The goal: slow the tick.
Read 14 tweets

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