Our paper looking at the long-term maturation of cortical organoids is out! rdcu.be/cfDQt #organoids #brainorganoids

TL;DR - human cortical organoids start to resemble postnatal cortical development after 250-300 days of culturing This work was a great collaboration between @GeschwindLab @PascaStanford @gracexiao99 and @HuguenardLab. Thank you to all coauthors @SeJinYoon3, Sthephan Tran, @MakinsonLab, @jimena_andersen, @FreddyMValencia and Steve Horvath

It’s out! “Neuronal defects in a human cellular model of 22q11.2 deletion syndrome” in which we used 3D human cortical spheroids neurons to study the pathways linked to neuropsychiatric disease in 22q11.2 deletion. rdcu.be/b7N8D

https://twitter.com/themasap/status/1310671122468282368

This work was a great collaboration with my co-first authors @themasap and @omerevah. A result of a vast collaboration between @PascaStanford @GeschwindLab @HuguenardLab @rdolmetsch @Winkytheelf, Porteus, Nishino, and Hallmayer labs.

Super excited to post my first preprint and first lead author paper from the Geschwind lab in which we used expression networks to find neuronal energetic to be abnormal across three mice model of psychiatric disorders. Thread to follow. 1/
biorxiv.org/content/10.110… We examined the cortical and hippocampal transcriptome in three mouse models of psychiatric disorders 15q13.3 deletion, 1q21.1 deletion and 22q11.2 deletion. Initial differential expression didn’t uncover any points of convergence between the different mouse models. 2/