Aedin Culhane Profile picture
Prof @MedicineAtUL, Computational immune oncology #bioinformatics, #biostatistics, #rstats, R, @bioconductor, women in STEM, parents in STEM, Tweets are my own
Dec 1, 2021 11 tweets 8 min read
Delighted to introduce correspondence analysis of scRNAseq. We show CA of Freeman-Tukey residuals outperforms CA of the Pearson Residuals

corral: Single-cell RNA-seq dimension reduction, batch integration, and visualization with correspondence analysis
biorxiv.org/content/10.110… Code to reproduce figures are available at github.com/laurenhsu1/cor….

Functions are available in the corral @bioconductor package. bioconductor.org/packages/relea…
Feb 17, 2020 16 tweets 7 min read
Mini tweetutorials on Eugenics, Statistics, Medicine Eugenics, "well born", was coined by Francis Galton, a cousin of Darwin. In 1873 he wrote, "hereditary-improvement". It claims the wealthy are a superior "breed" with higher intelligence. Genetics does not support his claims His comments on post-famine Irish were popular in Britain at the time, and many non-English groups were portrayed by negative stereotypes. He repeated a popular racist caricature. Modern genetic maps show that Ireland and Britain are genetically close.