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Andrew York Profile picture
Andrew York
@AndrewGYork
I'm a physicist; I develop new microscopy techniques.
May 26, 2020 • 4 tweets • 3 min read
How do you share your microscopy data? How should I share mine? How do you use shared microscopy data?

@coppola_s_PhD has an idea: let’s write an opinion piece together! @HenriquesLab and I are helping, and we need your help too!

Read the rules here: doi.org/10.5281/zenodo… @avtar00_singh, anyone at the Broad who you think would enjoy contributing?
Jan 29, 2020 • 9 tweets • 12 min read
Behold the "Scandreas", a trivially-aligned light-efficient alternative to lens-galvo-lens scanning!

Invented by Andreas Bodén @Bodeeen1 in @IlariaTesta4's lab, with assistance from @andreavolpato_ (and me!)

Video by @Kayley_Hake

Cite this tweet: doi.org/10.5281/zenodo… Andreas, Andrea and I were discussing Snoutscope alignment, and I was complaining about the scan unit: it's hard to align the galvo, and the scan lenses lose more light than we'd like. (Right, @DougPShepherd?)

Andreas asked my favorite question:

"Why don't you just...?"
Oct 3, 2019 • 12 tweets • 24 min read
@dopaminator @KaushikLab @arshukla @DeepakNModi @Sandeep_1966 @ViditaVaidya @Sci_Lipi @thattai "Do it yourself" publishing has been LIBERATING. You don't notice how "traditional" publishing warps your approach to science until you leave it behind.

Arguably the biggest advantage: I can focus on "how can I advance my field?", rather than "how can I get into a good journal?" @dopaminator @KaushikLab @arshukla @DeepakNModi @Sandeep_1966 @ViditaVaidya @Sci_Lipi @thattai I can focus on "how can I best communicate these ideas?", instead of "how can I get this past reviewers?".

I can focus on "how do I maximize impact?", rather than "how do I maximize impact factor?".
Jun 13, 2019 • 13 tweets • 9 min read
Microscopy technique development's exploding, but core facilities still buy confocals. This ugly baby will end that.

Less phototoxicity, WAY faster than confocal. NO DRAWBACK.

Details here: andrewgyork.github.io/high_na_single…

Co-invented by @amsikking.

Get one from jon@asiimaging.com I've heard there's "no free lunch" in microscopy; advantages come with tradeoffs. We take this as a personal challenge!

Our new microscope design gives the gentleness/speed of lightsheet microscopy, AND the high NA and simple sample prep you're used to with confocal microscopy.