🧵🔴 Acute Pancreatitis → Lung Injury (ALI/ARDS)

🫁 Lungs are often the earliest organ to fail in severe cases.
#MedTwitter #Gastroenterology #CriticalCare
#AcutePancreatitis #Pancreatitis #RespiratoryFailure
#Ventilation #IntensiveCare

pmc.ncbi.nlm.nih.gov/articles/PMC28… ⚡ Phases of ALI/ARDS in pancreatitis:
1️⃣ Exudative phase – alveolar damage, microvascular injury, inflammatory cell influx.
2️⃣ Fibro-proliferative phase – type II pneumocyte hyperplasia, fibroblasts, lung repair.
#ARDS #AcutePancreatitis

✨ APASL 2025 AVB Guidelines vs 2011 ✨

1️⃣ Refined definitions & risk stratification → “Home-to-door” 🏠➡️🏥, APASL Bleed Severity Score, HVPG, AI 🧠
2️⃣ Expanded rescue therapies → SEMS, early-TIPS, EUS-guided glue/thrombin, BRTO/CARTO/PARTO 💉
3️⃣ Personalized pharmacology → region-specific antibiotics 💊, tailored vasoactives
4️⃣ Standardized endoscopy → EVL = gold standard 👑 + anesthesia/risk guidance
5️⃣ Greater clinical focus → practical, Asia-Pacific-specific 🌏

👉 More precise, dynamic & practice-ready for better #AVB outcomes ✅

#Hepatology #GI #Liver #Cirrhosis #VaricealBleed #APASL2025 #Guidelines

link.springer.com/article/10.100… 📘 New APASL Definitions (2025)

🔴 Acute Variceal Bleeding (AVB):
➡️ Hematemesis within last 48h 🩸
➡️ Ongoing melena (last stool ≤24h) in suspected/known PHT

🔄 Re-bleeding (post AVB control):
⏰ Very early: 48–120h
🗓 Early: 120h – 42 days
📅 Late: >42 days