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Aude Bernheim Profile picture
Aude Bernheim
@AudeBer
Group leader @institutpasteur. @Mdmlab_paris Geneticist into how bacteria fight their viruses. Activist for more inclusive sciences
Sep 3, 2021 • 9 tweets • 5 min read
A bit lost with all the new anti-phage systems out there? We developed DefenseFinder, a tool to detect all known anti-viral systems in bacterial genomes and conducted a large scale analysis on the anti-viral arsenal of prokaryotes. See more below ! (1/9) biorxiv.org/cgi/content/sh… In the past few years, the world of anti-viral mechanisms in bacteria got crazy with the discovery of many novel systems with crazy cool mechanisms. Their numbers exploded, and so we ended up a bit lost. How many of these bacteria have? Which one is encoded by my favorite bug ?
Sep 16, 2020 • 11 tweets • 5 min read
Stoked to report in @nature the discovery of prokaryotic viperins, which naturally produce diverse anti-viral molecules !

After providing us with antibiotics, bacteria might become sources of novel anti-viral drugs. (1/9)
nature.com/articles/s4158… Viperin is an important immune protein in animals. In humans, it has broad antiviral activity against DNA and RNA viruses.
In 2018, this great paper showed that viperin inhibits the replication of viruses by producing ddhCTP, an RNA chain terminator.
nature.com/articles/s4158…