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Beck Laboratory Profile picture
Beck Laboratory
@Beck_Laboratory
In situ structural biology, cryo electron tomography and proteomics @MPIbp and @embl
Sep 2, 2020 • 6 tweets • 4 min read
Do you know how the architecture of the nuclear pore is linked to its assembly and turnover in living cells? Out in @nature now! Congratulations to @Matteoffm @ZimmerliChris @jankosinski @RantosVasileios Boris Pfander @embl @MPIbp @MPI_Biochem (1/6)

nature.com/articles/s4158… Structural biology in cellulo coupled to integrative modeling explains how the yeast nuclear pore accommodates mRNA export. (2/6 Image
Oct 17, 2019 • 11 tweets • 5 min read
How do you make nuclear pores away from the nucleus?
Our paper online today bit.ly/AL-NPC
@embl @a_schw @SchwabYannick @CellCellPress #development #Nuclearpores #microscopy
https://t.co/f4Xq1Vsk31
1/11 [a thread] Background: Mothers stockpile nuclear pores (NPCs) in the cytoplasm of their eggs to enable embryonic cell cycles that are too fast for conventional NPC assembly (bit.ly/ALembryo). These are arranged in stacked ER sheets called Annulate Lamellae (AL, see 4/11).
2/11