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Cd20+DLBCL Profile picture
Cd20+DLBCL
@CDlbcl
Tweeting at interface of Science, medicine, politics, and business. Apologist for medicines and medical device regulators: unsung heroes of COVID.
Jan 10, 2022 • 18 tweets • 5 min read
A thread on trust in vaccines.

Or why I think it is wrong to say say "we can't know vaccines are safe, because just look how long it took to discover the harm from smoking, x-rays, asbestos".

/ The "it is too soon to know it is safe" argument initially seems quite rational, and is the foundation of much vaccine hesitancy and widespread in anti-vaccine literature.

I don't want to focus on rebutting claims about the science, but to consider process and implications.

/
Nov 9, 2021 • 7 tweets • 3 min read
Great to be at an in person médical conference, on Alzheimers disease, in Boston. This particular conference was founded in 2008.

Quite some excitement that we are now in the therapeutic era for AD.

But so striking the conference kicked off by a panel of old men.
/1 ImageImage It is notable how the leaders of the field haven't really changed in 13 years. Some have died of course. But leadership seems very unrepresentative of the research base.

It is about time conference organizes avoided keynote panels limited to old white men.

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Nov 3, 2021 • 10 tweets • 4 min read
This headline is inappropriately alarmist given the content of the paper.

It will obviously be misused by anti vaxxers.

I thought it worth a short thread to highlight what it means.

TL;DR nothing in this paper undermine trust in data on BioNtech / Pfizer trials.

/1 A whistle blower reports poor compliance with Good Clinical Practice at a CRO managing 3 US sites in the Pfizer study.

There is no evidence that these errors would have undermined the scientific integrity of the trial results.

Example 1: needle disposal
/2 Image
May 15, 2021 • 19 tweets • 5 min read
Once again medicines regulations are becoming politically charged in the UK. Late last year it was rapid / hasty (depending in your view) MHRA authorization of COVID vaccines. Now it is about cancer treatments.

Brief thread on regulatory approval and market access.
/1 For your doctor to prescribe you a medicine, two things must be true (outside a clinical trial)

1. The medicine can legally be sold in the place you live (regulatory marketing authorization)
2. Someone (hopefully by you) is willing to pay for that medicine (reimbursement)

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May 14, 2021 • 5 tweets • 2 min read
More on the shocking resistance of western public health authorities to accept that diseases can be airborne.

Why? Unknowingly, are they are still fighting the centuries old battle about whether diseases spread through miasma (putrid air) or contact?
/1

en.m.wikipedia.org/wiki/Miasma_th… A big battle in the 19th century was whether doctors infected their patients through touch, and should therefore wash their hands.

Semmelweis was ridiculed by senior doctors for encouraging hand washing. Everyone knew disease was spread by miasma.

en.m.wikipedia.org/wiki/Ignaz_Sem….
Mar 13, 2020 • 10 tweets • 4 min read
Tough choices for governments in managing COVID-19.

With apologies to @olivierveran here are some sketches which I think illustrate options. We are plotting number of cases on y against time on x.

Firstly the do nothing option is the blue curve in this graph. The reason that is so bad is that at peak the number if cases would be well above the capacity - red line - of the healthcare system to cope. Insufficent ventilators, beds and staff would lead to higher proportion of cases dying than would otherwise be the case.
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