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CADDE Project Profile picture
CADDE Project
@CaddeProject
Brazil-UK Centre for (Arbo)virus Discovery, Diagnostics, Genomics and Epidemiology | funded by @MRC and @FAPESP #vacinacaocovid19
May 17, 2021 • 13 tweets • 9 min read
Our preprint about reinfection by the P.1 SARS-CoV-2 lineage in repeat blood donors in Manaus is now out [not peer-reviewed] 🧪🦠🥼🌎

▶️Check it out at: medrxiv.org/content/10.110….

▶️Short thread on key findings🧵 1/10 It is challenging to estimate the reinfection rate since most reinfected individuals are likely not tested, and/or oligo or asymptomatic. Yet, reinfection has been postulated to explain at least in part the 2nd wave of COVID-19 in Manaus (see bit.ly/3hyjVWk). 2/10
Feb 27, 2021 • 8 tweets • 4 min read
CADDE preprint. A SARS-CoV-2 lineage of concern is growing rapidly in Manaus and across Brazil. Using a combination of genomic and epidemiological data, we characterise the emergence and altered characteristics of this new variant, P.1. Here is a short thread of our findings. 1/8 What makes P.1 different? The lineage has an unusually high number of mutations, including some previously implicated as important in other variants - including a trio in the spike protein (K417T, E484K & N501Y) associated with increased binding to the human ACE2 receptor. 2/8